Disease relevance of Helminthiasis

• Metrifonate is a drug widely used to cure several helminthiases in man including cysticercosis [1].
• Flubendazole and mebendazole in the treatment of trichuriasis and other helminthiases [2].
• Effectiveness of two annual, single-dose mass drug administrations of diethylcarbamazine alone or in combination with albendazole on soil-transmitted helminthiasis in filariasis elimination programme [3].
• There are no reports documenting toxicity or adverse effects after treatment of children aged < 24 months with benzimidazole derivatives and there is an urgent need to clarify this point in light of the potential detrimental effect that soil-transmitted helminthiasis has on this age-group [4].
• When comparing helminthiases with allergic disorder, only hookworm disease (ECP and EPX) and onchocerciasis (EPX) exhibited significantly higher eosinophil cationic protein serum levels than atopic dermatitis [5].

High impact information on Helminthiasis

• Levamisole, the 1-isomer of tetramisole, is rapidly and completely absorbed, but has not been widely used in systemic helminthiases because of severe side effects associated with prolonged dosage [6].
• It is known that IgE antibodies are involved in the pathogenesis of both helminthiasis and atopy [7].
• However, FP did not react with sera from patients with other helminthiases [8].
• Albendazole in the treatment of intestinal helminthiasis in children [9].
• alpha 1-Acid glycoprotein, alpha 1-antitrypsin, and ceruloplasmin in human intestinal helminthiases [10].

Chemical compound and disease context of Helminthiasis

• The prophylactic effect of ivermectin treatment of calves, three weeks after turnout, on gastro-intestinal helminthiasis [11].
• Four anthelminthic drugs are considered to provide appropriate single dose treatment against soil-transmitted helminthiasis: albendazole, levamisole, mebendazole and pyrantel [12].
• The total serum IgE levels of these individuals were not significantly different from those with helminthiasis only, suggesting that there may be some form of repression of helminth-induced non-specific IgE in the presence of atopy; alternatively, allergen-related IgE may be repressed when an individual is worm-infested [13].
• Relationships between vitamin A, iron status and helminthiasis in Bangladeshi school children [14].
• Efficacy of oxfendazole in reducing bovine helminthiasis in field trials [15].

Biological context of Helminthiasis

• Anthropozoonotic helminthiases in Australasia: Part 3:--Studies on the prevalence and public health implications of helminth parasites of dogs and cats in urban environments [16].
• We considered the analysis of a study for Dorper, Red Maasai and crossbred lambs born over a period of 6 years at the Diani Estate, Kenya. The study was designed to compare survival and performance traits of genotypes with differing susceptibilities to helminthiasis [17].

Gene context of Helminthiasis

• No such competition was detected with the sera from other helminthiasis [18].
• Helminthiasis in India. Part I: Prevalence and geographical distribution: soil transmitted nematodes [19].
• Intestinal helminthiasis and anaemia in youngsters from Matriz da Luz, district of São Lourenço da Mata, state of Pernambuco, Brazil [20].
• Lastly, the review examines tubulin as a potential anticryptosporidial target in view of the fact that it has been exploited successfully for almost 50 years for the treatment of helminthiasis [21].

References