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Chemical Compound Review

Panacur     methyl N-(6-phenylsulfanyl-1H...

Synonyms: Fenbendazol, Phenbendasol, fenbendazole, Fenbendazolum, Safe-Guard, ...
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Disease relevance of fenbendazole


High impact information on fenbendazole


Chemical compound and disease context of fenbendazole


Biological context of fenbendazole

  • The maximum concentrations and area under the plasma concentration curve (AUC) of OFZ and FBZ were significantly higher (P less than 0.05) when OFZ was suspended in peanut oil than when administered as the commercial formulation [16].
  • Almost all SS genotype worms were eliminated by 1/4 of the FBZ recommended dose, whereas a significant fraction of the RS genotype worms survived treatment [17].
  • The fraction of the susceptible homozygote (SS), susceptible heterozygote (RS) and resistant homozygote (RR) genotypes were compared among FBZ dose groups to evaluate differences between SS and RS genotype selective advantage [17].
  • Bioavailability of fenbendazole was 27.1% [18].
  • The effect of a preparturient fenbendazole treatment on lactation yield in dairy cows [19].

Anatomical context of fenbendazole


Associations of fenbendazole with other chemical compounds


Gene context of fenbendazole

  • Fenbendazole treatment led to the inhibition of GDH, while G-6-PD, NADPH-D, cytochrome oxidase, monoamine oxidase and nonspecific esterase activity remained unaltered in the epithelium [27].
  • These values are 250-400 times greater than the inhibition constants of fenbendazole and mebendazole for A. suum embryonic tubulin [28].
  • In addition, measurements from TEM micrographs demonstrated a significant increase in microvillus surface area in the jejunum of fenbendazole-treated calves compared with saline-treated calves (31.2+/-10.2 vs. 22.8+/-7.6 microm(2)) [2].
  • Since those agents that induce CYP 2B1/2 isozymes and reduce Cx32 in centrilobular hepatocytes have been suggested to be liver tumor promoters, the present results indicate that fenbendazole may be a liver tumor promoter [29].
  • Similarly in vitro addition of fenbendazole to cytosolic glutathione S-transferase from the above species did not alter the activity of this enzyme [30].

Analytical, diagnostic and therapeutic context of fenbendazole

  • Group 2 was treated with fenbendazole (at 15 mg kg-1 bodyweight) to eliminate small lungworms, and the respiratory rate and blood gases were measured 3 weeks after treatment [31].
  • Quantitation of fenbendazole and its metabolites was conducted by high-pressure liquid chromatography using ultraviolet detection at 290 nm [20].
  • A high-performance liquid chromatographic (HPLC) method based on solid phase extraction was developed for the simultaneous determination of fenbendazole (FBZ), fenbendazole sulfoxide (FBZ-SO) and fenbendazole sulfone (FBZ-SO2) in trout muscle and skin tissues [32].
  • After oral administration, peak plasma concentration of fenbendazole was 0.07 microg/ml, time to peak plasma concentration was 3.75 hours, and mean residence time was 15.15 hours [18].
  • The animals of one group were given the bolus at turnout and the animals of the control group were treated with fenbendazole (7.5 mg/kg bodyweight) eight weeks after turnout [33].


  1. Influence of diet type on the kinetic disposition of fenbendazole in cattle and buffalo. Sanyal, P.K., Knox, M.R., Singh, D.K., Hennessy, D.R., Steel, J.W. Int. J. Parasitol. (1995) [Pubmed]
  2. Giardiasis in dairy calves: effects of fenbendazole treatment on intestinal structure and function. O'Handley, R.M., Buret, A.G., McAllister, T.A., Jelinski, M., Olson, M.E. Int. J. Parasitol. (2001) [Pubmed]
  3. The preventive effect of the fungus Duddingtonia flagrans on trichostrongyle infections of lambs on pasture. Githigia, S.M., Thamsborg, S.M., Larsen, M., Kyvsgaard, N.C., Nansen, P. Int. J. Parasitol. (1997) [Pubmed]
  4. Comparative persistent efficacy of doramectin, ivermectin and fenbendazole against natural nematode infections in cattle. Eddi, C., Muniz, R.A., Caracostantogolo, J., Errecalde, J.O., Rew, R.S., Michener, S.L., McKenzie, M.E. Vet. Parasitol. (1997) [Pubmed]
  5. Toxicity investigation of fenbendazole, an anthelmintic of swine. Hayes, R.H., Oehme, F.W., Leipold, H. Am. J. Vet. Res. (1983) [Pubmed]
  6. Hepatic microsomal metabolism of the anthelmintic benzimidazole fenbendazole: enhanced inhibition of cytochrome P450 reactions by oxidized metabolites of the drug. Murray, M., Hudson, A.M., Yassa, V. Chem. Res. Toxicol. (1992) [Pubmed]
  7. Transport of anthelmintic benzimidazole drugs by breast cancer resistance protein (BCRP/ABCG2). Merino, G., Jonker, J.W., Wagenaar, E., Pulido, M.M., Molina, A.J., Alvarez, A.I., Schinkel, A.H. Drug Metab. Dispos. (2005) [Pubmed]
  8. Comparative assessment of the access of albendazole, fenbendazole and triclabendazole to Fasciola hepatica: effect of bile in the incubation medium. Alvarez, L.I., Mottier, M.L., Lanusse, C.E. Parasitology (2004) [Pubmed]
  9. Characterisation of benzimidazole binding with recombinant tubulin from Giardia duodenalis, Encephalitozoon intestinalis, and Cryptosporidium parvum. MacDonald, L.M., Armson, A., Thompson, A.R., Reynoldson, J.A. Mol. Biochem. Parasitol. (2004) [Pubmed]
  10. Fenbendazole pharmacokinetics, metabolism, and potentiation in horses. McKellar, Q.A., Gokbulut, C., Muzandu, K., Benchaoui, H. Drug Metab. Dispos. (2002) [Pubmed]
  11. The effectiveness of benzimidazole derivatives for the treatment and prevention of histomonosis (blackhead) in turkeys. Hegngi, F.N., Doerr, J., Cummings, T.S., Schwartz, R.D., Saunders, G., Zajac, A., Larsen, C.T., Pierson, F.W. Vet. Parasitol. (1999) [Pubmed]
  12. The effects of mebendazole and fenbendazole on Trichinella spiralis in mice. Fernando, S.S., Deham, D.A. J. Parasitol. (1976) [Pubmed]
  13. Pharmacokinetics of fenbendazole in sheep. Marriner, S.E., Bogan, J.A. Am. J. Vet. Res. (1981) [Pubmed]
  14. Evaluation of fenbendazole as an anthelmintic for gastrointestinal nematodes of cattle. Craig, T.M., Bell, R.R. Am. J. Vet. Res. (1978) [Pubmed]
  15. Efficacy of dichlorvos, fenbendazole, and ivermectin in swine with induced intestinal nematode infections. Marchiondo, A.A., Szanto, J. Am. J. Vet. Res. (1987) [Pubmed]
  16. The effect of an oil formulation on the systemic availability of oxfendazole. Ali, D.N., Chick, B.F. Int. J. Parasitol. (1992) [Pubmed]
  17. Effect of benzimidazole under-dosing on the resistant allele frequency in Teladorsagia circumcincta (Nematoda). Silvestre, A., Cabaret, J., Humbert, J.F. Parasitology (2001) [Pubmed]
  18. Pharmacokinetics of fenbendazole following intravenous and oral administration to pigs. Petersen, M.B., Friis, C. Am. J. Vet. Res. (2000) [Pubmed]
  19. The effect of a preparturient fenbendazole treatment on lactation yield in dairy cows. McBeath, D.G., Dean, S.P., Preston, N.K. Vet. Rec. (1979) [Pubmed]
  20. Methodology for the analysis of fenbendazole and its metabolites in plasma, urine, feces, and tissue homogenates. Barker, S.A., Hsieh, L.C., Short, C.R. Anal. Biochem. (1986) [Pubmed]
  21. Bone marrow hypoplasia and intestinal crypt cell necrosis associated with fenbendazole administration in five painted storks. Weber, M.A., Terrell, S.P., Neiffer, D.L., Miller, M.A., Mangold, B.J. J. Am. Vet. Med. Assoc. (2002) [Pubmed]
  22. Influence of ruminal bypass on the pharmacokinetics and efficacy of benzimidazole anthelmintics in sheep. Steel, J.W., Hennessy, D.R. Int. J. Parasitol. (1999) [Pubmed]
  23. Determination of fenbendazole and oxfendazole in liver and muscle using liquid chromatography-mass spectrometry. Blanchflower, W.J., Cannavan, A., Kennedy, D.G. The Analyst. (1994) [Pubmed]
  24. Simultaneous determination of fenbendazole and its two metabolites and two triclabendazole metabolites in plasma by high-performance liquid chromatography. Lehr, K.H., Damm, P. J. Chromatogr. (1986) [Pubmed]
  25. Effect of benzimidazole drugs on the uptake of low molecular weight nutrients in Trichuris globulosa. Sarwal, R., Sanyal, S.N., Khera, S. Int. J. Parasitol. (1992) [Pubmed]
  26. Determination of fenbendazole, praziquantel and pyrantel pamoate in dog plasma by high-performance liquid chromatography. Morovján, G., Csokán, P., Makranszki, L., Abdellah-Nagy, E.A., Tóth, K. Journal of chromatography. A. (1998) [Pubmed]
  27. Histoenzymic effects of thiophenate and fenbendazole on the absorptive surfaces of Haemonchus contortus. Kaur, M., Sood, M.L. Acta Vet. Hung. (1992) [Pubmed]
  28. Interaction of anthelmintic benzimidazoles with Ascaris suum embryonic tubulin. Friedman, P.A., Platzer, E.G. Biochim. Biophys. Acta (1980) [Pubmed]
  29. Liver tumor promoting effects of fenbendazole in rats. Shoda, T., Onodera, H., Takeda, M., Uneyama, C., Imazawa, T., Takegawa, K., Yasuhara, K., Watanabe, T., Hirose, M., Mitsumori, K. Toxicologic pathology. (1999) [Pubmed]
  30. Lack of in vitro and in vitro effects of fenbendazole on phase I and phase II biotransformation enzymes in rats, mice and chickens. Dalvi, R.R., Gawai, K.R., Dalvi, P.S. Veterinary and human toxicology. (1991) [Pubmed]
  31. Impaired pulmonary gas exchange in ewes naturally infected by small lungworms. Berrag, B., Cabaret, J. Int. J. Parasitol. (1996) [Pubmed]
  32. Determination of fenbendazole and its metabolites in trout by a high-performance liquid chromatographic method. Sørensen, L.K., Hansen, H. The Analyst. (1998) [Pubmed]
  33. Field evaluation of a fenbendazole slow release bolus in the control of nematode infections in first-season cattle. Bauer, C., Holtemöller, H., Schmid, K. Vet. Rec. (1997) [Pubmed]
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