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MeSH Review


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Disease relevance of Syringoma


High impact information on Syringoma


Chemical compound and disease context of Syringoma


Anatomical context of Syringoma

  • We present two unrelated patients with numerous infraocular milium-like lesions that histologically revealed syringoma with many overlying keratin cysts in the papillary dermis [12].
  • CD44 was strongly expressed in epithelial cells at the peripheral row of syringomas and in cuticular areas of eccrine poromas [13].
  • To investigate biological characteristics of syringomas, three-dimensional (3-D) architectures of epithelial tumor nests and luminal structures of syringomas, hair follicles, and epidermal basement membrane in skin lesions were reconstructed using a computer stereographic analysis [14].
  • With regard to CK expression, the results indicate that syringoma represents a tumor differentiating toward both the uppermost part of the dermal duct and the lower intraepidermal duct (sweat duct ridge) of the eccrine sweat gland [15].
  • All tumors of eccrine gland origin, including syringoma, spiradenoma, poroma, porocarcinoma, and eccrine duct carcinoma (NOS), did not express CD10 [16].

Gene context of Syringoma

  • Immunohistochemical analysis of keratin expression in clear cell syringoma. A comparative study with conventional syringoma [17].
  • Conventional syringoma expressed CK1 and CK10, which exists in the acrosyringium and the transitional portion between the acrosyringium and the dermal duct [17].
  • Syringomas and malignant acrospiromas displayed EMA, CEA, and AE 14 reactivity, and 5 syringometaplastic lesions were AE 14-reactive [18].
  • Based on immunostaining with RCK102 and 35 beta H11, syringoma was thought to express CK5 [17].
  • A 26-year-old female is described with multiple facial syringomas, neonatal teeth and oligodontia [19].

Analytical, diagnostic and therapeutic context of Syringoma


  1. Adult-onset urticaria pigmentosa and eruptive syringomas. Claudy, A.L. J. Am. Acad. Dermatol. (1988) [Pubmed]
  2. The value of carcinoembryonic antigen in differentiating sclerosing epithelial hamartoma from syringoma. Landau-Price, D., Barnhill, R.L., Kowalcyzk, A.P., Penneys, N.S., Ziegels-Weissman, J. J. Cutan. Pathol. (1985) [Pubmed]
  3. Vulval syringoma successfully treated with tranilast. Iwao, F., Onozuka, T., Kawashima, T. Br. J. Dermatol. (2005) [Pubmed]
  4. Vulvar syringoma: a clinicopathologic and immunohistologic study of 18 patients and results of treatment. Huang, Y.H., Chuang, Y.H., Kuo, T.T., Yang, L.C., Hong, H.S. J. Am. Acad. Dermatol. (2003) [Pubmed]
  5. Progesterone receptor-positive eruptive syringoma associated with diabetes. Timpanidis, P.C., Lakhani, S.R., Groves, R.W. J. Am. Acad. Dermatol. (2003) [Pubmed]
  6. Eruptive pruritic syringomas: treatment with topical atropine. Sánchez, T.S., Daudén, E., Casas, A.P., García-Díez, A. J. Am. Acad. Dermatol. (2001) [Pubmed]
  7. The treatment of eruptive syringomas in an African American patient with a combination of trichloroacetic acid and CO2 laser destruction. Frazier, C.C., Camacho, A.P., Cockerell, C.J. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2001) [Pubmed]
  8. A new treatment for syringoma. Combination of carbon dioxide laser and trichloroacetic acid. Kang, W.H., Kim, N.S., Kim, Y.B., Shim, W.C. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (1998) [Pubmed]
  9. Response of multiple syringomas to isotretinoin. Mainitz, M., Schmidt, J.B., Gebhart, W. Acta Derm. Venereol. (1986) [Pubmed]
  10. Progesterone receptor positivity supports hormonal control of syringomas. Wallace, M.L., Smoller, B.R. J. Cutan. Pathol. (1995) [Pubmed]
  11. Treatment of multiple facial syringomas with the carbon dioxide (CO2) laser. Wang, J.I., Roenigk, H.H. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (1999) [Pubmed]
  12. Syringoma presenting as milia. Friedman, S.J., Butler, D.F. J. Am. Acad. Dermatol. (1987) [Pubmed]
  13. CD44 distribution in sweat gland tumors suggests it has different functional roles in the various cell types. Fernández-Figueras, M.T., Puig, L., Ariza, A., Calatrava, A., Fuente, M.J., Ferrándiz, C. The American Journal of dermatopathology. (1996) [Pubmed]
  14. Stereographic analysis of syringomas. Ito, M., Yokoyama, H., Ikeda, K., Sato, Y. Arch. Dermatol. Res. (1990) [Pubmed]
  15. Distribution of cytokeratin polypeptides in syringomas. An immunohistochemical study on paraffin-embedded material. Eckert, F., Nilles, M., Schmid, U., Altmannsberger, M. The American Journal of dermatopathology. (1992) [Pubmed]
  16. Expression of CD10 in basal cell carcinoma. Yada, K., Kashima, K., Daa, T., Kitano, S., Fujiwara, S., Yokoyama, S. The American Journal of dermatopathology. (2004) [Pubmed]
  17. Immunohistochemical analysis of keratin expression in clear cell syringoma. A comparative study with conventional syringoma. Ohnishi, T., Watanabe, S. J. Cutan. Pathol. (1997) [Pubmed]
  18. Microcystic adnexal carcinoma. An immunohistochemical comparison with other cutaneous appendage tumors. Wick, M.R., Cooper, P.H., Swanson, P.E., Kaye, V.N., Sun, T.T. Archives of dermatology. (1990) [Pubmed]
  19. Syringomas, natal teeth and oligodontia: a new ectodermal dysplasia? Morrison, P.J., Young, I.D. Clin. Dysmorphol. (1996) [Pubmed]
  20. Clear-cell syringoma. Immunohistochemistry and electron microscopy study. Ambrojo, P., Requena Caballero, L., Aguilar Martínez, A., Sánchez Yus, E., Furió, V. Dermatologica (1989) [Pubmed]
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