Disease relevance of Syringoma

• Adult-onset urticaria pigmentosa and eruptive syringomas [1].
• The value of carcinoembryonic antigen in differentiating sclerosing epithelial hamartoma from syringoma [2].

High impact information on Syringoma

• Vulval syringoma successfully treated with tranilast [3].
• In our study, estrogen receptor and progesterone receptor were not detected in vulvar syringoma [4].
• METHODS: A total of 18 cases of vulvar syringoma were selected from the surgical pathologic file at Chang Gung Memorial Hospital. In all, 15 formalin-fixed, paraffin-embedded specimens were examined by immunohistochemical staining for estrogen receptor and progesterone receptor [4].
• We report a case in which eruptive syringoma with clear cell morphology was found to express progesterone receptors, suggesting the possibility of hormonal control of the tumor [5].
• Eruptive pruritic syringomas: treatment with topical atropine [6].

Chemical compound and disease context of Syringoma

• RESULTS: While the syringomas were not completely ablated, the combination of TCA and CO2 laser resurfacing provided acceptable cosmetic results without significant side effects [7].
• A new treatment for syringoma. Combination of carbon dioxide laser and trichloroacetic acid [8].
• Response of multiple syringomas to isotretinoin [9].
• Syringomas may be at least partially under estrogen and/or progesterone influence, as they are more common in women and are known to proliferate at puberty [10].
• Treatment of multiple facial syringomas with the carbon dioxide (CO2) laser [11].

Anatomical context of Syringoma

• We present two unrelated patients with numerous infraocular milium-like lesions that histologically revealed syringoma with many overlying keratin cysts in the papillary dermis [12].
• CD44 was strongly expressed in epithelial cells at the peripheral row of syringomas and in cuticular areas of eccrine poromas [13].
• To investigate biological characteristics of syringomas, three-dimensional (3-D) architectures of epithelial tumor nests and luminal structures of syringomas, hair follicles, and epidermal basement membrane in skin lesions were reconstructed using a computer stereographic analysis [14].
• With regard to CK expression, the results indicate that syringoma represents a tumor differentiating toward both the uppermost part of the dermal duct and the lower intraepidermal duct (sweat duct ridge) of the eccrine sweat gland [15].
• All tumors of eccrine gland origin, including syringoma, spiradenoma, poroma, porocarcinoma, and eccrine duct carcinoma (NOS), did not express CD10 [16].

Gene context of Syringoma

• Immunohistochemical analysis of keratin expression in clear cell syringoma. A comparative study with conventional syringoma [17].
• Conventional syringoma expressed CK1 and CK10, which exists in the acrosyringium and the transitional portion between the acrosyringium and the dermal duct [17].
• Syringomas and malignant acrospiromas displayed EMA, CEA, and AE 14 reactivity, and 5 syringometaplastic lesions were AE 14-reactive [18].
• Based on immunostaining with RCK102 and 35 beta H11, syringoma was thought to express CK5 [17].
• A 26-year-old female is described with multiple facial syringomas, neonatal teeth and oligodontia [19].

Analytical, diagnostic and therapeutic context of Syringoma

• Immunohistochemistry for carcinoembryonic antigen (CEA) showed ordinary syringomas as in the presence of CEA within and surrounding duct-like spaces [20].

References