Disease relevance of Facial Hemiatrophy

• Etiologies of facial asymmetry included hemifacial microsomia, hemifacial atrophy, postradiation sequelae, burns and trauma, and selected congenital anomalies [1].
• Of these patients, three had traumatic craniofacial or facial deformities, one had congenital craniofacial deformity, two had hemifacial atrophy (one because of radiation), one had hemifacial microsomia, and one had localized frontonasal lipodystrophy [2].
• RESULTS: Clinical observation revealed classic hemifacial atrophy; fluorescein angiography showed telangiectasis, light staining of the retina, and leakage from the largest telangiectasis and the optic disc vessels; echography showed shrinkage of the eyeball and thinning of the extraocular muscles [3].
• The patients included two craniosynostosis, four craniofacial tumours, five hemicraniofacial microsomias, one facial and skull base arteriovenous malformation, one orbitofacial neurofibromatosis and two hemifacial atrophies with extensive facial skeletal involvement [4].

High impact information on Facial Hemiatrophy

• Progressive facial hemiatrophy and epilepsy: a common underlying dysgenetic mechanism [5].
• This study is the first reported case of the Parry-Romberg syndrome, with intractable temporal lobe epilepsy, in which detailed microanatomic analyses have been performed on resected brain tissue obtained after surgical intervention [6].
• Indications were tumor resections, burn wound, hemifacial atrophy, trauma, and moyamoya disease [7].
• Epileptic seizures, one of the major neurologic complications of progressive facial hemiatrophy, could precede the succeeding neurocutaneous changes [8].
• Quiz case 2. Progressive hemifacial atrophy (Parry-Romberg syndrome) [9].

Chemical compound and disease context of Facial Hemiatrophy

• Tongue-flap reconstruction of the lip vermilion in hemifacial atrophy [10].

Anatomical context of Facial Hemiatrophy

• BACKGROUND: Progressive hemifacial atrophy, widely referred to as Parry-Romberg syndrome or Romberg's disease, is a rare pathologic process characterized by an acquired, idiopathic, self-limited, unilateral atrophy of the face, variably involving skin, subcutaneous tissues, fat, muscle and, less frequently, the underlying bone structures [11].

Gene context of Facial Hemiatrophy

• Unilateral arrested myopia preceded other signs of progressive facial hemiatrophy in a 13-year-old girl [12].
• Duane's retraction syndrome with facial hemiatrophy [13].
• Management of craniofacial development in the Parry-Romberg syndrome: report of two patients [14].
• Surgical techniques using microvascular anastomoses and free flap transfers can now be applied in the management of patients with such conditions as Romberg disease, postirradiation hypoplasia of the face, and Goldenhar syndrome, and in patients with bronchial arch developmental defects [15].
• Facial hemiatrophy (Parry-Romberg syndrome) and hypertrophic cardiomyopathy [16].

References