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Gene Review

MYMY1  -  moyamoya disease 1

Homo sapiens

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Disease relevance of MYMY1


Psychiatry related information on MYMY1


High impact information on MYMY1


Chemical compound and disease context of MYMY1


Biological context of MYMY1

  • Our results indicate that the leptomeningeal vessels of moyamoya disease are not newly formed but are merely dilated preexisting vessels and that the structural alteration of the vascular walls suggests their adaptability for participation in the collateral circulation at the cerebral surface [18].
  • BACKGROUND AND PURPOSE: We have previously reported that cerebral blood flow decreased and oxygen extraction fraction and cerebral blood volume increased in pediatric patients with moyamoya disease, whereas these values did not change significantly in adult patients [19].
  • We measured cerebral perfusion at rest and in response to CO2 in eight patients with moyamoya disease (MMD), using the 133xenon inhalation method to determine the effect of large-vessel occlusive disease on vasoreactivity [20].
  • The clinical features and HLA phenotypes described in Asian monozygotic twins with MMD were not found in our patients [21].
  • CONCLUSIONS: These findings suggest that there may be a genetic predisposition for moyamoya disease and that host factors may play a role in the development of intimal thickening in early childhood [22].

Anatomical context of MYMY1


Associations of MYMY1 with chemical compounds


Physical interactions of MYMY1

  • Kinetics of 125I-PDGF binding at 37 degrees C in cells from moyamoya disease showed fewer binding sites (less than 1/3 of controls) and lower degradation per cell than in those from controls, though no difference was observed in either internalization or degradation of each receptor [32].

Regulatory relationships of MYMY1

  • The colocalization of inflammatory cells and PCNA-positive cells suggests that inflammatory stimuli may induce proliferative response of smooth muscle and contribute to the formation of the intracranial occlusive lesions in moyamoya disease [33].

Other interactions of MYMY1


Analytical, diagnostic and therapeutic context of MYMY1


  1. Mapping of a familial moyamoya disease gene to chromosome 3p24.2-p26. Ikeda, H., Sasaki, T., Yoshimoto, T., Fukui, M., Arinami, T. Am. J. Hum. Genet. (1999) [Pubmed]
  2. Variant angina pectoris associated with moyamoya disease. Ikeda, U., Fujikawa, H., Shimada, K. Lancet (1998) [Pubmed]
  3. Intracranial saccular aneurysm and moyamoya disease. Adams, H.P., Kassell, N.F., Wisoff, H.S., Drake, C.G. Stroke (1979) [Pubmed]
  4. Caudate hemorrhage with moyamoya-like vasculopathy from atherosclerotic disease. Steinke, W., Tatemichi, T.K., Mohr, J.P., Massaro, A., Prohovnik, I., Solomon, R.A. Stroke (1992) [Pubmed]
  5. Quantitative evaluation of cerebral hemodynamics in patients with moyamoya disease by dynamic susceptibility contrast magnetic resonance imaging--comparison with positron emission tomography. Tanaka, Y., Nariai, T., Nagaoka, T., Akimoto, H., Ishiwata, K., Ishii, K., Matsushima, Y., Ohno, K. J. Cereb. Blood Flow Metab. (2006) [Pubmed]
  6. Surgical treatment of moyamoya disease: operative technique for encephalo-duro-arterio-myo-synangiosis, its follow-up, clinical results, and angiograms. Kinugasa, K., Mandai, S., Kamata, I., Sugiu, K., Ohmoto, T. Neurosurgery (1993) [Pubmed]
  7. Serial intelligence test scores in pediatric moyamoya disease. Imaizumi, C., Imaizumi, T., Osawa, M., Fukuyama, Y., Takeshita, M. Neuropediatrics. (1999) [Pubmed]
  8. Childhood moyamoya presenting as dementia: report of a case. Levin, S.D., Hoare, R.D., Robinson, R.O. Developmental medicine and child neurology. (1983) [Pubmed]
  9. Clinical features of moyamoya disease in sibling relations under 15 years of age. Hamada, J.I., Yoshioka, S., Nakahara, T., Marubayashi, T., Ushio, Y. Acta neurochirurgica. (1998) [Pubmed]
  10. Pulse-inversion contrast harmonic imaging: ultrasonographic assessment of cerebral perfusion. Meairs, S., Daffertshofer, M., Neff, W., Eschenfelder, C., Hennerici, M. Lancet (2000) [Pubmed]
  11. Response of moyamoya disease to verapamil. McLean, M.J., Gebarski, S.S., van der Spek, A.F., Goldstein, G.W. Lancet (1985) [Pubmed]
  12. Renal artery lesions in patients with moyamoya disease: angiographic findings. Yamada, I., Himeno, Y., Matsushima, Y., Shibuya, H. Stroke (2000) [Pubmed]
  13. Hyperventilation technetium-99m-HMPAO brain SPECT in moyamoya disease to assess risk of natural childbirth. Kume, N., Hayashida, K., Shimotsu, Y., Matsunaga, N. J. Nucl. Med. (1997) [Pubmed]
  14. Steroid-responsive chorea in moyamoya disease. Pavlakis, S.G., Schneider, S., Black, K., Gould, R.J. Mov. Disord. (1991) [Pubmed]
  15. The effectiveness of O2 administration for transient ischemic attacks in moyamoya disease in children. Fujiwara, J., Nakahara, S., Enomoto, T., Nakata, Y., Takita, H. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. (1996) [Pubmed]
  16. Refractory hypertension in childhood--efficacy of captopril therapy. Yamagishi, M., Kaneko, M., Chiba, K., Ohji, T., Kohri, T. J. UOEH (1987) [Pubmed]
  17. Iodine-123 IMP SPECT before and after bypass surgery in a patient with occlusion of left anterior and middle cerebral arteries with basal abnormal telangiectasis (unilateral Moyamoya disease). Honda, N., Machida, K., Takishima, T., Kaizu, H., Sugimoto, E. Annals of nuclear medicine. (1987) [Pubmed]
  18. Histopathologic and morphometric studies of leptomeningeal vessels in moyamoya disease. Kono, S., Oka, K., Sueishi, K. Stroke (1990) [Pubmed]
  19. Response to hypercapnia in moyamoya disease. Cerebrovascular response to hypercapnia in pediatric and adult patients with moyamoya disease. Kuwabara, Y., Ichiya, Y., Sasaki, M., Yoshida, T., Masuda, K., Matsushima, T., Fukui, M. Stroke (1997) [Pubmed]
  20. Reduced hypercapnic vasoreactivity in moyamoya disease. Tatemichi, T.K., Prohovnik, I., Mohr, J.P., Correll, J.W., Quest, D.O., Jarvis, L. Neurology (1988) [Pubmed]
  21. Moyamoya disease in Italian monozygotic twins. Andreone, V., Ciarmiello, A., Fusco, C., Ambrosanio, G., Florio, C., Linfante, I. Neurology (1999) [Pubmed]
  22. Human leukocyte antigen in patients with moyamoya disease. Aoyagi, M., Ogami, K., Matsushima, Y., Shikata, M., Yamamoto, M., Yamamoto, K. Stroke (1995) [Pubmed]
  23. Effectiveness of superficial temporal artery-middle cerebral artery anastomosis in adult moyamoya disease: cerebral hemodynamics and clinical course in ischemic and hemorrhagic varieties. Okada, Y., Shima, T., Nishida, M., Yamane, K., Yamada, T., Yamanaka, C. Stroke (1998) [Pubmed]
  24. Systemic vascular changes in spontaneous occlusion of the circle of Willis. Ikeda, E. Stroke (1991) [Pubmed]
  25. Early development of intimal thickening in superficial temporal arteries in patients with moyamoya disease. Aoyagi, M., Fukai, N., Yamamoto, M., Nakagawa, K., Matsushima, Y., Yamamoto, K. Stroke (1996) [Pubmed]
  26. Ultrastructural studies of cerebral arteries and collateral vessels in moyamoya disease. Takebayashi, S., Matsuo, K., Kaneko, M. Stroke (1984) [Pubmed]
  27. Surgically induced angiogenesis to compensate for hemodynamic cerebral ischemia. Nariai, T., Suzuki, R., Matsushima, Y., Ichimura, K., Hirakawa, K., Ishii, K., Senda, M. Stroke (1994) [Pubmed]
  28. Cerebral perfusion imaging evaluates pharmacologic treatment of unilateral moyamoya disease. Kuroki, M., Nagamachi, S., Hoshi, H., Flores, L.G., Ohnishi, T., Jinnouchi, S., Futami, S., Watanabe, K. J. Nucl. Med. (1996) [Pubmed]
  29. The advantage of coronal scanning in cerebral computed angiotomography for diagnosis of moyamoya disease. Asari, S., Satoh, T., Sakurai, M., Yamamoto, Y., Sadamoto, K. Radiology. (1982) [Pubmed]
  30. "Ivy sign" in childhood moyamoya disease: depiction on FLAIR and contrast-enhanced T1-weighted MR images. Yoon, H.K., Shin, H.J., Chang, Y.W. Radiology. (2002) [Pubmed]
  31. The effect of propofol sedation in pregnancy on neonatal condition. Bacon, R.C., Razis, P.A. Anaesthesia. (1994) [Pubmed]
  32. Kinetics of 125I-PDGF binding and down-regulation of PDGF receptor in arterial smooth muscle cells derived from patients with moyamoya disease. Aoyagi, M., Fukai, N., Matsushima, Y., Yamamoto, M., Yamamoto, K. J. Cell. Physiol. (1993) [Pubmed]
  33. Smooth muscle cell proliferation and localization of macrophages and T cells in the occlusive intracranial major arteries in moyamoya disease. Masuda, J., Ogata, J., Yutani, C. Stroke (1993) [Pubmed]
  34. A novel heterozygous missense mutation 377T > C (V126A) of TGIF gene in a family segregated with holoprosencephaly and moyamoya disease. Chen, M., Kuo, S.J., Liu, C.S., Chen, W.L., Ko, T.M., Chen, T.H., Chang, S.P., Huang, C.H., Chang, Y.Y., Wang, B.T. Prenat. Diagn. (2006) [Pubmed]
  35. Increased expression of hepatocyte growth factor in cerebrospinal fluid and intracranial artery in moyamoya disease. Nanba, R., Kuroda, S., Ishikawa, T., Houkin, K., Iwasaki, Y. Stroke (2004) [Pubmed]
  36. Differences in cellular responses to mitogens in arterial smooth muscle cells derived from patients with moyamoya disease. Yamamoto, M., Aoyagi, M., Fukai, N., Matsushima, Y., Yamamoto, K. Stroke (1998) [Pubmed]
  37. Fanconi anemia and moyamoya: evidence for an association. Pavlakis, S.G., Verlander, P.C., Gould, R.J., Strimling, B.C., Auerbach, A.D. Neurology (1995) [Pubmed]
  38. Preoperative and postoperative evaluation of cerebral perfusion and vasodilatory capacity with 99mTc-HMPAO SPECT and acetazolamide in childhood Moyamoya disease. Touho, H., Karasawa, J., Ohnishi, H. Stroke (1996) [Pubmed]
  39. Diagnosis of moyamoya disease with magnetic resonance angiography. Houkin, K., Aoki, T., Takahashi, A., Abe, H. Stroke (1994) [Pubmed]
  40. Effects of surgical revascularization on outcome of patients with pediatric moyamoya disease. Ishikawa, T., Houkin, K., Kamiyama, H., Abe, H. Stroke (1997) [Pubmed]
  41. Cerebral infarction due to moyamoya disease in young adults. Bruno, A., Adams, H.P., Biller, J., Rezai, K., Cornell, S., Aschenbrener, C.A. Stroke (1988) [Pubmed]
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