Disease relevance of Facial Asymmetry

• Saethre-Chotzen syndrome (acrocephalo-syndactyly type III, ACS III) is an autosomal dominant craniosynostosis with brachydactyly, soft tissue syndactyly and facial dysmorphism including ptosis, facial asymmetry and prominent ear crura [1].
• The most common phenotypic features, present in more than a third of our patients with TWIST mutations, are coronal synostosis, brachycephaly, low frontal hairline, facial asymmetry, ptosis, hypertelorism, broad great toes, and clinodactyly [2].
• The affected males have mild-to-moderate mental retardation (MR), hypotonia, cerebellar circuitry dysfunction, facial asymmetry, thin habitus, osteoporosis, kyphoscoliosis, decreased activity of SMS, correspondingly low levels of intracellular spermine in lymphocytes and fibroblasts, and elevated spermidine/spermine ratios [3].
• Recognised clinical signs include EXT, FPP, mental retardation, facial asymmetry, asymmetric calcification of coronary sutures, defective vision (severe myopia, nystagmus, strabismus), skeletal anomalies (small hands and feet, tapering fingers), heart defect, and anal stenosis [4].
• Abnormal features included mental retardation, delayed development, microcephaly, encephalocele, hearing loss, hypertelorism, ptosis, flat nasal bridge, protruding upper incisors, facial asymmetry, short neck, hypoplastic thumbs, scoliosis and clubfeet [5].

High impact information on Facial Asymmetry

• These include: facial asymmetry, down-slanting palpebral fissures, ptosis, prominent nose, long philtrum, down-turned mouth, midline crease in the lower lip, puffy cheeks, and micrognathia [6].
• Delayed speech development, facial asymmetry, strabismus, and transverse ear lobe creases: a new syndrome [7]?
• We performed a prospective study of neuroimaging studies and temporal lobe pathology in 13 patients with facial asymmetry and intractable partial epilepsy of temporal lobe origin [8].
• It was first described in 1969 in French. Isolated cases in the literature have been associated with facial asymmetry, plagiocephaly, and the Dandy-Walker syndrome [9].
• We report a proximal 7p interstitial inverted duplication in a mother and daughter both of whom have features of SRS, including marked short stature, low birth weight, facial asymmetry and 5th finger clinodactyly [10].

Chemical compound and disease context of Facial Asymmetry

• This led to a progressive asymmetry of the rami, clinically expressed by some degree of facial asymmetry and an occlusal cant [11].
• A high resolution cadmium telluride probe was used in conjunction with standard bone imaging methods in two cases of facial asymmetry [12].

Anatomical context of Facial Asymmetry

• Statistical comparison with a control group showed characteristic dental anomalies in the facial asymmetry group, including asymmetry of the curve of Spee, molar inclination, dental arch form, lateral overjet, and slanting of the occlusal plane [13].
• We present an 11-year-old patient with grade II hemifacial microsomia with facial asymmetry that was corrected with a combined simultaneous distraction of the maxilla and mandible using a single mandibular distraction device and an interdental splint [14].

Gene context of Facial Asymmetry

• Facial asymmetry may occur in patients with partial epilepsy related to remote symptomatic seizures and mesial temporal sclerosis [8].
• The child was the product of a consanguinous pregnancy, and manifested poor growth, relative microcephaly, facial asymmetry, and a malformed left ear [15].
• Progression of facial asymmetry in hemifacial microsomia [16].
• Facial asymmetry: recognition of TMD [17].
• Facial asymmetries in hemifacial microsomia, Goldenhar syndrome, and Treacher Collins syndrome [18].

Analytical, diagnostic and therapeutic context of Facial Asymmetry

• OBJECTIVE: To present orthodontic treatment combined with mandibular distraction osteogenesis using an intraoral device and a bite plate in a patient with hemifacial microsomia, severe facial asymmetry, and unilateral mandibular hypoplasia [19].

References