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MeSH Review

Dissociative Disorders

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Psychiatry related information on Dissociative Disorders


High impact information on Dissociative Disorders

  • Primary and secondary kinetic isotope effects indicate that this ribozyme stabilizes a highly dissociative reaction with considerable sp2 hybridization and negligible bond order between the departing pyrophosphate leaving group and the anomeric carbon [5].
  • OBJECTIVE: There may be an association between a low serum cholesterol level and dissociative disorders [6].
  • RESULTS: Patients with dissociative disorders had lower serum triglyceride, total cholesterol, low-density lipoprotein, and very low density lipoprotein levels than normal comparison subjects [6].
  • For the dianionic substrate, a dissociative reaction pathway with early proton transfer to the leaving group and a 9 kcal/mol energy barrier is predicted (the experimental estimate is ca. 14 kcal/mol), while for the monoanionic substrate, an associative pathway with late proton transfer and a 22 kcal/mol energy barrier is predicted [7].
  • The authors propose that intensified, dystonic affects, characteristic of the interictal period in temporal lobe epilepsy, may predispose some individuals to dissociative reactions [8].

Chemical compound and disease context of Dissociative Disorders


Gene context of Dissociative Disorders


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  5. An oxocarbenium-ion intermediate of a ribozyme reaction indicated by kinetic isotope effects. Unrau, P.J., Bartel, D.P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
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  9. Attenuation of ketamine effects by nimodipine pretreatment in recovering ethanol dependent men: psychopharmacologic implications of the interaction of NMDA and L-type calcium channel antagonists. Krupitsky, E.M., Burakov, A.M., Romanova, T.N., Grinenko, N.I., Grinenko, A.Y., Fletcher, J., Petrakis, I.L., Krystal, J.H. Neuropsychopharmacology (2001) [Pubmed]
  10. The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor. Shi, W., Li, C.M., Tyler, P.C., Furneaux, R.H., Cahill, S.M., Girvin, M.E., Grubmeyer, C., Schramm, V.L., Almo, S.C. Biochemistry (1999) [Pubmed]
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  16. Psychogenic coma: case report. Baxter, C.L., White, W.D. International journal of psychiatry in medicine. (2003) [Pubmed]
  17. Recent research on multiple personality disorder. Putnam, F.W. Psychiatr. Clin. North Am. (1991) [Pubmed]
  18. Predictors of post-traumatic stress disorder following severe injury. Mellman, T.A., David, D., Bustamante, V., Fins, A.I., Esposito, K. Depression and anxiety. (2001) [Pubmed]
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