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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Dissociative Disorders

 
 
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Psychiatry related information on Dissociative Disorders

 

High impact information on Dissociative Disorders

  • Primary and secondary kinetic isotope effects indicate that this ribozyme stabilizes a highly dissociative reaction with considerable sp2 hybridization and negligible bond order between the departing pyrophosphate leaving group and the anomeric carbon [5].
  • OBJECTIVE: There may be an association between a low serum cholesterol level and dissociative disorders [6].
  • RESULTS: Patients with dissociative disorders had lower serum triglyceride, total cholesterol, low-density lipoprotein, and very low density lipoprotein levels than normal comparison subjects [6].
  • For the dianionic substrate, a dissociative reaction pathway with early proton transfer to the leaving group and a 9 kcal/mol energy barrier is predicted (the experimental estimate is ca. 14 kcal/mol), while for the monoanionic substrate, an associative pathway with late proton transfer and a 22 kcal/mol energy barrier is predicted [7].
  • The authors propose that intensified, dystonic affects, characteristic of the interictal period in temporal lobe epilepsy, may predispose some individuals to dissociative reactions [8].
 

Chemical compound and disease context of Dissociative Disorders

 

Gene context of Dissociative Disorders

References

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  2. Psychometric properties of the Dissociative Experiences Scale. Dubester, K.A., Braun, B.G. J. Nerv. Ment. Dis. (1995) [Pubmed]
  3. The dissociative disorders. Rarely considered and underdiagnosed. Coons, P.M. Psychiatr. Clin. North Am. (1998) [Pubmed]
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  5. An oxocarbenium-ion intermediate of a ribozyme reaction indicated by kinetic isotope effects. Unrau, P.J., Bartel, D.P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  6. Serum lipid levels in patients with dissociative disorder. Agargun, M.Y., Ozer, O.A., Kara, H., Sekeroglu, R., Selvi, Y., Eryonucu, B. The American journal of psychiatry. (2004) [Pubmed]
  7. Density functional study of the mechanism of a tyrosine phosphatase: I. Intermediate formation. Asthagiri, D., Dillet, V., Liu, T., Noodleman, L., Van Etten, R.L., Bashford, D. J. Am. Chem. Soc. (2002) [Pubmed]
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  9. Attenuation of ketamine effects by nimodipine pretreatment in recovering ethanol dependent men: psychopharmacologic implications of the interaction of NMDA and L-type calcium channel antagonists. Krupitsky, E.M., Burakov, A.M., Romanova, T.N., Grinenko, N.I., Grinenko, A.Y., Fletcher, J., Petrakis, I.L., Krystal, J.H. Neuropsychopharmacology (2001) [Pubmed]
  10. The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor. Shi, W., Li, C.M., Tyler, P.C., Furneaux, R.H., Cahill, S.M., Girvin, M.E., Grubmeyer, C., Schramm, V.L., Almo, S.C. Biochemistry (1999) [Pubmed]
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  15. Dissociative disorders in Turkish inpatients with conversion disorder. Tezcan, E., Atmaca, M., Kuloglu, M., Gecici, O., Buyukbayram, A., Tutkun, H. Comprehensive psychiatry. (2003) [Pubmed]
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