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Gene Review

IMPACT  -  impact RWD domain protein

Homo sapiens

Synonyms: Imprinted and ancient gene protein homolog, Protein IMPACT, RWDD5
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Disease relevance of IMPACT


Psychiatry related information on IMPACT


High impact information on IMPACT


Chemical compound and disease context of IMPACT


Biological context of IMPACT

  • Global Translational Responses to Oxidative Stress Impact upon Multiple Levels of Protein Synthesis [21].
  • Here we identified IMPACT, the human homolog of Impact, on chromosome 18q11 [22].
  • To reveal the structural basis for the difference in allelic expression between the two species, we elucidated complete genome sequences for both mouse Impact ( approximately 38 kb) and human IMPACT ( approximately 30 kb) [22].
  • An evolutionary scenario for genomic imprinting of Impact lying between nonimprinted neighbors [23].
  • Since Impact not only lies in an intergenic region but also consists of 11 exons, it does not seem to be an imprinted gene generated by a retrotransposition [23].

Anatomical context of IMPACT


Associations of IMPACT with chemical compounds


Regulatory relationships of IMPACT


Other interactions of IMPACT


Analytical, diagnostic and therapeutic context of IMPACT


  1. Confidential HIV testing and condom promotion in Africa. Impact on HIV and gonorrhea rates. Allen, S., Serufilira, A., Bogaerts, J., Van de Perre, P., Nsengumuremyi, F., Lindan, C., Carael, M., Wolf, W., Coates, T., Hulley, S. JAMA (1992) [Pubmed]
  2. Depression following myocardial infarction. Impact on 6-month survival. Frasure-Smith, N., Lespérance, F., Talajic, M. JAMA (1993) [Pubmed]
  3. Transmission of HIV-1 infections from mothers to infants in Haiti. Impact on childhood mortality and malnutrition. The CDS/JHU AIDS Project Team. Halsey, N.A., Boulos, R., Holt, E., Ruff, A., Brutus, J.R., Kissinger, P., Quinn, T.C., Coberly, J.S., Adrien, M., Boulos, C. JAMA (1990) [Pubmed]
  4. Coinfection with human T-cell lymphotropic virus type I and HIV in Brazil. Impact on markers of HIV disease progression. Schechter, M., Harrison, L.H., Halsey, N.A., Trade, G., Santino, M., Moulton, L.H., Quinn, T.C. JAMA (1994) [Pubmed]
  5. The 1996 Albert Lasker Medical Research Awards. Prevention of systemic infections, especially meningitis, caused by Haemophilus influenzae type b. Impact on public health and implications for other polysaccharide-based vaccines. Robbins, J.B., Schneerson, R., Anderson, P., Smith, D.H. JAMA (1996) [Pubmed]
  6. Human homolog of the mouse imprinted gene Impact resides at the pericentric region of chromosome 18 within the critical region for bipolar affective disorder. Kosaki, K., Suzuki, T., Kosaki, R., Yoshihashi, H., Itoh, M., Goto, Y., Matsuo, N. Mol. Psychiatry (2001) [Pubmed]
  7. Risk for bladder cancer. Psychological impact of notification. Hornsby, J.L., Sappington, J.T., Mongan, P., Gullen, W.H., Bono, S.F., Altekruse, E. JAMA (1985) [Pubmed]
  8. Physical and pharmacologic restraint of nursing home patients with dementia. Impact of specialized units. Sloane, P.D., Mathew, L.J., Scarborough, M., Desai, J.R., Koch, G.G., Tangen, C. JAMA (1991) [Pubmed]
  9. Prevalence and predictors of psychological distress among women with ovarian cancer. Norton, T.R., Manne, S.L., Rubin, S., Carlson, J., Hernandez, E., Edelson, M.I., Rosenblum, N., Warshal, D., Bergman, C. J. Clin. Oncol. (2004) [Pubmed]
  10. Effects of pool-based and land-based aerobic exercise on women with fibromyalgia/chronic widespread muscle pain. Jentoft, E.S., Kvalvik, A.G., Mengshoel, A.M. Arthritis Rheum. (2001) [Pubmed]
  11. The Functional Impact of SLC6 Transporter Genetic Variation. Hahn, M.K., Blakely, R.D. Annu. Rev. Pharmacol. Toxicol. (2007) [Pubmed]
  12. Alpha 1-antitrypsin deficiency. Impact of genetic discovery on medicine and society. Wulfsberg, E.A., Hoffmann, D.E., Cohen, M.M. JAMA (1994) [Pubmed]
  13. Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis. Quyyumi, A.A., Dakak, N., Andrews, N.P., Husain, S., Arora, S., Gilligan, D.M., Panza, J.A., Cannon, R.O. J. Clin. Invest. (1995) [Pubmed]
  14. Stat Bite. Impact of combination chemotherapy for advanced testicular cancer. Feuer, E.J. J. Natl. Cancer Inst. (1992) [Pubmed]
  15. Will Screening Colonoscopy Disappear and Transform Gastroenterology Practice? Threats to Clinical Practice and Recommendations to Reduce Their Impact: Report of a Consensus Conference Conducted by the AGA Institute Future Trends Committee. Regueiro, C.R. Gastroenterology (2006) [Pubmed]
  16. A public health model for cardiovascular risk reduction. Impact of cholesterol screening with brief nonphysician counseling. Gemson, D.H., Sloan, R.P., Messeri, P., Goldberg, I.J. Arch. Intern. Med. (1990) [Pubmed]
  17. Natural recovery and treatment-seeking in pathological gambling: results of two U.S. national surveys. Slutske, W.S. The American journal of psychiatry. (2006) [Pubmed]
  18. Review of 404 patients with gastrointestinal fistulas. Impact of parenteral nutrition. Soeters, P.B., Ebeid, A.M., Fischer, J.E. Ann. Surg. (1979) [Pubmed]
  19. Effects of intravenous theophylline on exercise-induced myocardial ischemia. I. Impact on the ischemic threshold. Heller, G.V., Barbour, M.M., Dweik, R.B., Corning, J.J., McClellan, J.R., Garber, C.E. J. Am. Coll. Cardiol. (1993) [Pubmed]
  20. Evaluation of intravenous ciprofloxacin in patients with nosocomial lower respiratory tract infections. Impact of plasma concentrations, organism, minimum inhibitory concentration, and clinical condition on bacterial eradication. Peloquin, C.A., Cumbo, T.J., Nix, D.E., Sands, M.F., Schentag, J.J. Arch. Intern. Med. (1989) [Pubmed]
  21. Global Translational Responses to Oxidative Stress Impact upon Multiple Levels of Protein Synthesis. Shenton, D., Smirnova, J.B., Selley, J.N., Carroll, K., Hubbard, S.J., Pavitt, G.D., Ashe, M.P., Grant, C.M. J. Biol. Chem. (2006) [Pubmed]
  22. Comparative genome analysis of the mouse imprinted gene impact and its nonimprinted human homolog IMPACT: toward the structural basis for species-specific imprinting. Okamura, K., Hagiwara-Takeuchi, Y., Li, T., Vu, T.H., Hirai, M., Hattori, M., Sakaki, Y., Hoffman, A.R., Ito, T. Genome Res. (2000) [Pubmed]
  23. An evolutionary scenario for genomic imprinting of Impact lying between nonimprinted neighbors. Okamura, K., Yamada, Y., Sakaki, Y., Ito, T. DNA Res. (2004) [Pubmed]
  24. Interrupted aortic arch. Impact of subaortic stenosis on management and outcome. Jacobs, M.L., Chin, A.J., Rychik, J., Steven, J.M., Nicolson, S.C., Norwood, W.I. Circulation (1995) [Pubmed]
  25. Muscle sympathetic nerve activity in response to glucose ingestion. Impact of plasma insulin and body fat. Spraul, M., Anderson, E.A., Bogardus, C., Ravussin, E. Diabetes (1994) [Pubmed]
  26. Suppression of cytoskeletal rearrangement in activated human neutrophils by botulinum C2 toxin. Impact on cellular signal transduction. Grimminger, F., Sibelius, U., Aktories, K., Just, I., Seeger, W. J. Biol. Chem. (1991) [Pubmed]
  27. Candidate metabolic network states in human mitochondria. Impact of diabetes, ischemia, and diet. Thiele, I., Price, N.D., Vo, T.D., Palsson, B.Ø. J. Biol. Chem. (2005) [Pubmed]
  28. Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP. Werner-Felmayer, G., Werner, E.R., Fuchs, D., Hausen, A., Reibnegger, G., Schmidt, K., Weiss, G., Wachter, H. J. Biol. Chem. (1993) [Pubmed]
  29. Angioplasty triggers intracoronary leukotrienes and lipoxin A4. Impact of aspirin therapy. Brezinski, D.A., Nesto, R.W., Serhan, C.N. Circulation (1992) [Pubmed]
  30. A model of health status for rheumatoid arthritis. A factor analysis of the Arthritis Impact Measurement Scales. Mason, J.H., Anderson, J.J., Meenan, R.F. Arthritis Rheum. (1988) [Pubmed]
  31. Deletion mutagenesis of human cystathionine beta-synthase. Impact on activity, oligomeric status, and S-adenosylmethionine regulation. Oliveriusová, J., Kery, V., Maclean, K.N., Kraus, J.P. J. Biol. Chem. (2002) [Pubmed]
  32. Community cholesterol screening. Impact of labeling on participant behavior. Gordon, R.L., Klag, M.J., Whelton, P.K. Arch. Intern. Med. (1990) [Pubmed]
  33. Posttraumatic stress symptoms and salivary cortisol levels. Anisman, H., Griffiths, J., Matheson, K., Ravindran, A.V., Merali, Z. The American journal of psychiatry. (2001) [Pubmed]
  34. Genetic Impact of Functional Single Nucleotide Polymorphisms in the 3'-UTR Region of the Chemoattractant Receptor Expressed on Th2 Cells (CRTH2) Gene on Asthma and Atopy in a Japanese Population. Maeda, Y., Hizawa, N., Takahashi, D., Fukui, Y., Konno, S., Nishimura, M. Int. Arch. Allergy Immunol. (2007) [Pubmed]
  35. Intraphagosomal Mycobacterium tuberculosis acquires iron from both extracellular transferrin and intracellular iron pools. Impact of interferon-gamma and hemochromatosis. Olakanmi, O., Schlesinger, L.S., Ahmed, A., Britigan, B.E. J. Biol. Chem. (2002) [Pubmed]
  36. Genetic polymorphism of VEGF: Impact on longitudinal change of peritoneal transport and survival of peritoneal dialysis patients. Szeto, C.C., Chow, K.M., Poon, P., Szeto, C.Y., Wong, T.Y., Li, P.K. Kidney Int. (2004) [Pubmed]
  37. Expression of cyclooxygenase-2 and 12-lipoxygenase in human breast cancer and their relationship with HER-2/neu and hormonal receptors: Impact on prognosis and therapy. Mohammad, A.M., Abdel, H.A., Abdel, W., Ahmed, A.M., Wael, T., Eiman, G. Indian journal of cancer (2006) [Pubmed]
  38. A PK-PD Model for Predicting the Impact of Age, CYP2C9, and VKORC1 Genotype on Individualization of Warfarin Therapy. Hamberg, A.K., Dahl, M.L., Barban, M., Scordo, M.G., Wadelius, M., Pengo, V., Padrini, R., Jonsson, E.N. Clin. Pharmacol. Ther. (2007) [Pubmed]
  39. Forced expression of desmin and desmin mutants in cultured cells: Impact of myopathic missense mutations in the central coiled-coil domain on network formation. Bär, H., Kostareva, A., Sjöberg, G., Sejersen, T., Katus, H.A., Herrmann, H. Exp. Cell Res. (2006) [Pubmed]
  40. What transplantation can teach us about health care reform. The Ethics and Social Impact Committee. Benjamin, M., Cohen, C., Grochowski, E. N. Engl. J. Med. (1994) [Pubmed]
  41. A randomized trial of physical rehabilitation for very frail nursing home residents. Mulrow, C.D., Gerety, M.B., Kanten, D., Cornell, J.E., DeNino, L.A., Chiodo, L., Aguilar, C., O'Neil, M.B., Rosenberg, J., Solis, R.M. JAMA (1994) [Pubmed]
  42. On-site physician staffing in a community hospital intensive care unit. Impact on test and procedure use and on patient outcome. Li, T.C., Phillips, M.C., Shaw, L., Cook, E.F., Natanson, C., Goldman, L. JAMA (1984) [Pubmed]
  43. Donor transaminase and recipient hepatitis. Impact on blood transfusion services. Alter, H.J., Purcell, R.H., Holland, P.V., Alling, D.W., Koziol, D.E. JAMA (1981) [Pubmed]
  44. Alcoholics and liver transplantation. The Ethics and Social Impact Committee of the Transplant and Health Policy Center. Cohen, C., Benjamin, M. JAMA (1991) [Pubmed]
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