Disease relevance of Depersonalization

• Paroxetine for depersonalization associated with multiple sclerosis [1].

Psychiatry related information on Depersonalization

• Eight patients with depersonalization disorder or with depersonalization symptoms in association with obsessive-compulsive and panic disorders were treated with serotonin reuptake blockers [2].
• CONCLUSIONS: Primary dissociative conditions, such as depersonalization disorder, may be associated with a pattern of HPA axis dysregulation that differs from PTSD and merits further study [3].
• On day 11, she developed a psychotic disorder not otherwise specified, most probably caused by chloroquine use, with symptoms of depersonalization and anxiety [4].
• Similar correlation patterns were found for both groups: The QED factor "depersonalization" correlated highly with the coping behaviors "resignation," "social isolation," "self-blame," "self-compassion," and "rumination." No correlation between Factor 2 "fantasies/daydreams" and the coping behavior was found [5].

High impact information on Depersonalization

• OBJECTIVE: The goal of this study was to assess brain glucose metabolism and its relationship to dissociation measures and clinical symptoms in DSM-IV depersonalization disorder [6].
• Depersonalization had been typically treatment refractory; only serotonin reuptake inhibitors and, to a lesser extent, benzodiazepines had been of any therapeutic benefit [7].
• Depersonalization treated with fluoxetine [8].
• Depersonalization following nitrazepam withdrawal [9].
• Lamotrigine in the treatment of depersonalization disorder [10].

Chemical compound and disease context of Depersonalization

• Fluoxetine in depersonalization disorder [11].
• The use of fluoxetine and buspirone for treatment-refractory depersonalization disorder [12].
• As with other GABA agonists and GABA-mimetic drugs, side effects included giddiness, depersonalization, poor concentration, and transitory delirious states, suggesting that excessive stimulation of the GABAergic system may disrupt normal brain functioning [13].
• Therefore, we hypothesised that in healthy subjects ketamine would elicit neural responses to emotional stimuli which mimicked those reported in depersonalization disorder and schizophrenia [14].
• A patient with a depersonalization and derealization syndrome took 1 g doxycycline per day [15].

Anatomical context of Depersonalization

• The relationship between episodic depersonalization, temporal lobe pathology, and epilepsy is discussed against the background of this case [16].

Gene context of Depersonalization

• During the attacks the patient had depersonalization, showing a stiff face, and the electroencephalogram showed constant 5 Hz diffuse theta waves [17].
• Episodic depersonalization in focal epilepsy [16].
• The effect of primary care nursing and feelings of isolation/depersonalization of the critical care nurse: Part I--Background for the study [18].

References