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MeSH Review


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Disease relevance of MMPI


Psychiatry related information on MMPI


High impact information on MMPI


Chemical compound and disease context of MMPI

  • Chromatographic profiles indicated that an approximately 27-kDa MMPI was specifically increased in the CM of retinol-treated cells, whereas a 22-18.5-kDa MMPI was increased in CM derived from retinoic acid-treated cells [16].
  • The MMPI synthesized by retinol-treated EC was immunologically related to tissue inhibitor of metalloproteinases, type 1 (TIMP-1), and the MMPI produced by retinoic acid-treated cells was related to TIMP-2, as indicated by biosynthetic labeling and immunoprecipitation studies as well as Western blot analysis [16].
  • The delineation of an MMPI symptom pattern unique to lithium responders [8].
  • The variables of sex, diagnosis, diurnal mood variation, platelet MAO activity, and MMPI scale scores were of minimal assistance in revealing factors that might be associated with activation or antidepressant responses to dextro-amphetamine in this small patient group [17].
  • Creatine phosphokinase, the MMPI, and psychosis [18].

Biological context of MMPI

  • RESULTS: In this study we have confirmed that marimastat is a broad spectrum MMPI with a bioavailability of 5% [19].
  • Blood and urine were obtained from 33 psychiatric inpatients on the day after admission, at which time the patients completed the UCLA Loneliness Scale, the Psychiatric Epidemiology Research Interview Life Events Scale (PERI), and the MMPI [20].
  • We observed downregulation of several matrix metalloproteinases (MMPs), i.e., MMPI and MMP3, and MMP10 in the transfected cells [21].
  • Event-related potentials (ERPs) were examined in 16 college students who had high scores on the Schizophrenia Scale of the MMPI (HSS) but were without a hereditary disposition for major psychiatric disorders [22].
  • To test the possibility of ex vivo model as a therapeutic guideline for MMP inhibitor (MMPI) treatment, we evaluated IC50 of the gabexate mesylate against MMP-9 [23].

Anatomical context of MMPI


Gene context of MMPI

  • RESULTS: MMP expression was greater in the synovial lining layer (LL) than in the synovial sublining layer (SL) in both PsA and RA tissue for most MMP except collagenase I (MMPI), which was equally distributed between the LL and SL [26].
  • Instead of TIMP-2, various MMP inhibitors (MMPI) such as BB-2516 have been investigated with regard to suppression of tumor progression and improvement of prognosis in patients with advanced cancers, which resulted in no clinical efficacy [27].
  • IL-6 levels were not affected by the MMPI [28].
  • CONCLUSION: We conclude that measurement of plasma MMP-7 or MMP-9 levels, as performed in our trial, was not a useful prognostic or predictive factor in patients with MBC or in patients treated with an MMPI [29].
  • In organotypic hippocampal cultures, which lack blood cell-mediated inflammation and extrinsic connections, a broad-spectrum inhibitor of MMPs (MMPI), but also a selective MMP-9 inhibitor, protect hippocampal neurons against KA-induced excitotoxicity [30].

Analytical, diagnostic and therapeutic context of MMPI

  • Three psychological tests were administered to each patient: the Minnesota Multiphasic Personality Inventory, the Cornell Medical Index, and the Quick Test (a measure of mental ability) [31].
  • Those with high scores for psychopathic deviance (MMPI) differed in glucose levels following OGTT from those with low scores [32].
  • Those retained comprised a range of procedures [seizure induction, MMPI assessment, physiological assessment (prolactin, SPECT), pre-ictal pseudosleep, and ictal/post-ictal characteristics] [33].
  • METHODS: A longitudinal, case-control, double-blind study comparing presymptomatic gene carriers and nongene carriers at risk for HD evaluated with an abbreviated MMPI and a quantified neurologic rating scale examined an average of 3.7 years apart [34].
  • Seventy-eight male and 21 female cocaine dependents and 70 male and 24 female alcoholics, hospitalized in a dual diagnosis program, were administered the MMPI, Millon Clinical Multiaxial Inventory-II (MCMI-II), Rorschach, Beck Depression Inventory, and Shipley Institute of Living Scale, after a 2-week stabilization period [35].


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  16. Retinoids modulate endothelial cell production of matrix-degrading proteases and tissue inhibitors of metalloproteinases (TIMP). Braunhut, S.J., Moses, M.A. J. Biol. Chem. (1994) [Pubmed]
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  19. The effect of an inhibitor of matrix metalloproteinases on colonic inflammation in a trinitrobenzenesulphonic acid rat model of inflammatory bowel disease. Sykes, A.P., Bhogal, R., Brampton, C., Chander, C., Whelan, C., Parsons, M.E., Bird, J. Aliment. Pharmacol. Ther. (1999) [Pubmed]
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  21. Redox regulation of matrix metalloproteinase gene family in small cell lung cancer cells. Savaraj, N., Wei, Y., Unate, H., Liu, P.M., Wu, C.J., Wangpaichitr, M., Xia, D., Xu, H.J., Hu, S.X., Tien Kuo, M. Free Radic. Res. (2005) [Pubmed]
  22. Deviate P200 and P300 in non-patient college students with high scores on the schizophrenia scale of the Minnesota Multiphasic Personality Inventory (MMPI). Ogura, C., Hirano, K., Nageishi, Y., Takeshita, S., Fukao, K., Hokama, H., Ohta, H., Arakaki, H. International journal of psychophysiology : official journal of the International Organization of Psychophysiology. (1994) [Pubmed]
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  26. Gelatinase expression and activity in the synovium and skin of patients with erosive psoriatic arthritis. Hitchon, C.A., Danning, C.L., Illei, G.G., El-Gabalawy, H.S., Boumpas, D.T. J. Rheumatol. (2002) [Pubmed]
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  30. Neuronal activity-dependent increase of net matrix metalloproteinase activity is associated with MMP-9 neurotoxicity after kainate. Jourquin, J., Tremblay, E., Décanis, N., Charton, G., Hanessian, S., Chollet, A.M., Le Diguardher, T., Khrestchatisky, M., Rivera, S. Eur. J. Neurosci. (2003) [Pubmed]
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