Disease relevance of MMPI

• Thirty patients with fibrositis and 2 control groups, one of rheumatoid arthritis patients and the other of arthritis patients with other than rheumatoid arthritis, were compared on the basis of the Minnesota Multiphasic Personality Inventory (MMPI) to assess the role of psychologic factors in fibrositis [1].
• Cluster of MMPI personality profiles in chronic tension-type headache and predictable response to Fluoxetine [2].
• In this study, we investigated the associations between lipopolysaccharide (LPS)-induced goblet cell (GC) metaplasia and EGFR expression and the effects of MMP inhibitor (MMPI) [3].
• We studied the synthetic matrix metalloproteinase inhibitor (MMPI) prinomastat (AG3340) in a well-established NCI-H460 orthotopic lung cancer model that exhibits highly predictable regional and systemic metastatic patterns [4].
• Interestingly, MMPI, an inhibitor of TNF-alpha convertase, stabilizes the membrane potential in both types of hemorrhagic shock [5].

Psychiatry related information on MMPI

• The Minnesota Multiphasic Personality Inventory (MMPI) scales for Hypochondriasis, Depression, and Hysteria were studied in patients with rheumatoid arthritis (RA) [6].
• Patients completed modified versions of the Beck Depression Inventory, the Zung Self-Rating Depression Scale, the MMPI depression scale, the Thematic Apperception Test, and the Psychopathology Instrument for Mentally Retarded Adults [7].
• Statistical analyses of the MMPI scores of lithium responders, lithium nonresponders, and a group of patients receiving other psychotropic drugs revealed that the depression, psychasthenia, mania, and social introversion scale scores significantly differentiated the lithium response and lithium nonresponse groups [8].
• We compared 20 patients with Lyme encephalopathy with 11 fibromyalgia patients and 11 nonpsychotically depressed patients using the California Verbal Learning Test, Wechsler Memory Scale, Rey-Osterrieth Complex Figure Test, Minnesota Multiphasic Personality Inventory (MMPI), and Beck Depression Inventory [9].
• Correlations with psychometric test data showed PIP rate in REM to be related to the psychoticism scale of the Minnesota Multiphasic Personality Inventory and MEMA rate in REM to be inversely related to the Barron Ego Strength scale [10].

High impact information on MMPI

• The Family APGAR, Impact of Event Scale, and Improved Readability Form of the Minnesota Multiphasic Personality Inventory were administered within four weeks of the initial medical screening and readministered six months later [11].
• This cleavage is inhibited by a matrix metalloproteinase inhibitor (MMPI) [12].
• The degree to which serum gastrin fluctuated was unrelated to personality, as assessed by Minnesota Multiphasic Personality Inventory [13].
• Highest yields were associated with EEGs, thyroid function studies, vitamin B12 and folate levels, and the Minnesota Multiphasic Personality Inventory [14].
• Those individuals with a low level of DBH in the CSF had significantly elevated profiles on the Minnesota Multiphasic Personality Inventory, suggesting a relationship between the central noradrenergic system and some aspects of personality in man [15].

Chemical compound and disease context of MMPI

• Chromatographic profiles indicated that an approximately 27-kDa MMPI was specifically increased in the CM of retinol-treated cells, whereas a 22-18.5-kDa MMPI was increased in CM derived from retinoic acid-treated cells [16].
• The MMPI synthesized by retinol-treated EC was immunologically related to tissue inhibitor of metalloproteinases, type 1 (TIMP-1), and the MMPI produced by retinoic acid-treated cells was related to TIMP-2, as indicated by biosynthetic labeling and immunoprecipitation studies as well as Western blot analysis [16].
• The delineation of an MMPI symptom pattern unique to lithium responders [8].
• The variables of sex, diagnosis, diurnal mood variation, platelet MAO activity, and MMPI scale scores were of minimal assistance in revealing factors that might be associated with activation or antidepressant responses to dextro-amphetamine in this small patient group [17].
• Creatine phosphokinase, the MMPI, and psychosis [18].

Biological context of MMPI

• RESULTS: In this study we have confirmed that marimastat is a broad spectrum MMPI with a bioavailability of 5% [19].
• Blood and urine were obtained from 33 psychiatric inpatients on the day after admission, at which time the patients completed the UCLA Loneliness Scale, the Psychiatric Epidemiology Research Interview Life Events Scale (PERI), and the MMPI [20].
• We observed downregulation of several matrix metalloproteinases (MMPs), i.e., MMPI and MMP3, and MMP10 in the transfected cells [21].
• Event-related potentials (ERPs) were examined in 16 college students who had high scores on the Schizophrenia Scale of the MMPI (HSS) but were without a hereditary disposition for major psychiatric disorders [22].
• To test the possibility of ex vivo model as a therapeutic guideline for MMP inhibitor (MMPI) treatment, we evaluated IC50 of the gabexate mesylate against MMP-9 [23].

Anatomical context of MMPI

• The MMPI profile of RMTD pts is similar to those with definite temporal lobe epilepsy but different from pts with general medical disorders [24].
• MAIN OUTCOME MEASURE(S): Peritoneal fluid was analyzed for PA, PAI, MMP, and MMPI activities [25].

Gene context of MMPI

• RESULTS: MMP expression was greater in the synovial lining layer (LL) than in the synovial sublining layer (SL) in both PsA and RA tissue for most MMP except collagenase I (MMPI), which was equally distributed between the LL and SL [26].
• Instead of TIMP-2, various MMP inhibitors (MMPI) such as BB-2516 have been investigated with regard to suppression of tumor progression and improvement of prognosis in patients with advanced cancers, which resulted in no clinical efficacy [27].
• IL-6 levels were not affected by the MMPI [28].
• CONCLUSION: We conclude that measurement of plasma MMP-7 or MMP-9 levels, as performed in our trial, was not a useful prognostic or predictive factor in patients with MBC or in patients treated with an MMPI [29].
• In organotypic hippocampal cultures, which lack blood cell-mediated inflammation and extrinsic connections, a broad-spectrum inhibitor of MMPs (MMPI), but also a selective MMP-9 inhibitor, protect hippocampal neurons against KA-induced excitotoxicity [30].

Analytical, diagnostic and therapeutic context of MMPI

• Three psychological tests were administered to each patient: the Minnesota Multiphasic Personality Inventory, the Cornell Medical Index, and the Quick Test (a measure of mental ability) [31].
• Those with high scores for psychopathic deviance (MMPI) differed in glucose levels following OGTT from those with low scores [32].
• Those retained comprised a range of procedures [seizure induction, MMPI assessment, physiological assessment (prolactin, SPECT), pre-ictal pseudosleep, and ictal/post-ictal characteristics] [33].
• METHODS: A longitudinal, case-control, double-blind study comparing presymptomatic gene carriers and nongene carriers at risk for HD evaluated with an abbreviated MMPI and a quantified neurologic rating scale examined an average of 3.7 years apart [34].
• Seventy-eight male and 21 female cocaine dependents and 70 male and 24 female alcoholics, hospitalized in a dual diagnosis program, were administered the MMPI, Millon Clinical Multiaxial Inventory-II (MCMI-II), Rorschach, Beck Depression Inventory, and Shipley Institute of Living Scale, after a 2-week stabilization period [35].

References