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Chemical Compound Review

NCGC00164580-01     (9S,17R)-17-(2- chloroethanoyl)-9-fluoro- 11...

Synonyms: EINECS 246-633-8, Clobetasol [INN:BAN], Clobetasolum [INN-Latin]
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Disease relevance of clobetasol


Psychiatry related information on clobetasol

  • RESULTS: After 2 weeks, psoriasis scores were significantly lower (P < .001) in the combination therapy group (adjusted trunk lesion score = 0.67) compared with monotherapy with either agent (lesion scores = 1.40 calcipotriene, 1.13 clobetasol foam) [6].

High impact information on clobetasol


Chemical compound and disease context of clobetasol


Biological context of clobetasol


Anatomical context of clobetasol


Associations of clobetasol with other chemical compounds


Gene context of clobetasol


Analytical, diagnostic and therapeutic context of clobetasol


  1. Anti-CD11a ameliorates disease in the human psoriatic skin-SCID mouse transplant model: comparison of antibody to CD11a with Cyclosporin A and clobetasol propionate. Zeigler, M., Chi, Y., Tumas, D.B., Bodary, S., Tang, H., Varani, J. Lab. Invest. (2001) [Pubmed]
  2. Treatment of periocular capillary hemangioma with topical clobetasol propionate. Cruz, O.A., Zarnegar, S.R., Myers, S.E. Ophthalmology (1995) [Pubmed]
  3. Combination of calcipotriene (Dovonex) ointment and tazarotene (Tazorac) gel versus clobetasol ointment in the treatment of plaque psoriasis: a pilot study. Bowman, P.H., Maloney, J.E., Koo, J.Y. J. Am. Acad. Dermatol. (2002) [Pubmed]
  4. Penile lichen sclerosus et atrophicus treated with clobetasol dipropionate 0.05% cream: a retrospective clinical and histopathological study. Dahlman-Ghozlan, K., Hedblad, M.A., von Krogh, G. J. Am. Acad. Dermatol. (1999) [Pubmed]
  5. Patient satisfaction after the treatment of vulvovaginal erosive lichen planus with topical clobetasol and tacrolimus: a survey study. Jensen, J.T., Bird, M., Leclair, C.M. Am. J. Obstet. Gynecol. (2004) [Pubmed]
  6. A randomized, multicenter study of calcipotriene ointment and clobetasol propionate foam in the sequential treatment of localized plaque-type psoriasis: short- and long-term outcomes. Koo, J., Blum, R.R., Lebwohl, M. J. Am. Acad. Dermatol. (2006) [Pubmed]
  7. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Homey, B., Alenius, H., Müller, A., Soto, H., Bowman, E.P., Yuan, W., McEvoy, L., Lauerma, A.I., Assmann, T., Bünemann, E., Lehto, M., Wolff, H., Yen, D., Marxhausen, H., To, W., Sedgwick, J., Ruzicka, T., Lehmann, P., Zlotnik, A. Nat. Med. (2002) [Pubmed]
  8. Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models. Sheu, M.Y., Fowler, A.J., Kao, J., Schmuth, M., Schoonjans, K., Auwerx, J., Fluhr, J.W., Man, M.Q., Elias, P.M., Feingold, K.R. J. Invest. Dermatol. (2002) [Pubmed]
  9. Ultraviolet irradiation increases matrix metalloproteinase-8 protein in human skin in vivo. Fisher, G.J., Choi, H.C., Bata-Csorgo, Z., Shao, Y., Datta, S., Wang, Z.Q., Kang, S., Voorhees, J.J. J. Invest. Dermatol. (2001) [Pubmed]
  10. Potencies of topical glucocorticoids to mediate genomic and nongenomic effects on human peripheral blood mononuclear cells. Naumann, L., Feist, E., Straub, R.H., Burmester, G.R., Buttgereit, F. Biochem. Pharmacol. (2006) [Pubmed]
  11. Type-IV hypersensitivity to betamethasone valerate and clobetasol propionate: results of a multicentre study. Sommer, S., Wilkinson, S.M., English, J.S., Gawkrodger, D.J., Green, C., King, C.M., Powell, S., Sansom, J.E., Shaw, S. Br. J. Dermatol. (2002) [Pubmed]
  12. A double-blind, multicenter comparison of 0.05% halobetasol propionate ointment and 0.05% clobetasol propionate ointment in patients with chronic, localized plaque psoriasis. Goldberg, B., Hartdegen, R., Presbury, D., Smith, E.H., Yawalkar, S. J. Am. Acad. Dermatol. (1991) [Pubmed]
  13. The influence of a topical corticosteroid on short-contact high-dose dithranol therapy. Swinkels, O.Q., Prins, M., Tosserams, E.F., Gerritsen, M.J., Van Der Valk, P.G., Van De Kerkhof, P.C. Br. J. Dermatol. (2001) [Pubmed]
  14. Topical clobetasol-17-propionate: review of its clinical efficacy and safety. Olsen, E.A., Cornell, R.C. J. Am. Acad. Dermatol. (1986) [Pubmed]
  15. A study of the comparative efficacy of diflucortolone valerate 0.3% ointment and clobetasol propionate 0.05% ointment. Wendt, H., Mugglestone, C.J., Wiseman, R.A. Br. J. Dermatol. (1978) [Pubmed]
  16. Cutaneous reactive hyperaemia: racial differences induced by corticoid application. Berardesca, E., Maibach, H. Br. J. Dermatol. (1989) [Pubmed]
  17. Evaluation of in vivo bioequivalence methodology for topical clobetasol 17-propionate based on pharmacodynamic modeling using Chinese skin. Tsai, J.C., Cheng, C.L., Tsai, Y.F., Sheu, H.M., Chou, C.H. Journal of pharmaceutical sciences. (2004) [Pubmed]
  18. Effect of low frequency ultrasound on the in vitro percutaneous absorption of clobetasol 17-propionate. Fang, J., Fang, C., Sung, K.C., Chen, H. International journal of pharmaceutics. (1999) [Pubmed]
  19. Bioavailability of clobetasol propionate in different vehicles. Franz, T.J., Lehman, P.A., Feldman, S.R., Spellman, M.C. Skin Pharmacol. Appl. Skin Physiol. (2003) [Pubmed]
  20. Evaluation of the effects of topical clobetasol propionate by visual score, electrical impedance and laser Doppler flowmetry. Emtestam, L., Kuzmina, N., Talme, T. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) (2007) [Pubmed]
  21. Inhibition by glucocorticoids of the mast cell-dependent weal and flare response in human skin in vivo. Cole, Z.A., Clough, G.F., Church, M.K. Br. J. Pharmacol. (2001) [Pubmed]
  22. Effects of corticosteroids on the growth and metabolism of fibroblasts cultured from human skin. Priestley, G.C. Br. J. Dermatol. (1978) [Pubmed]
  23. Lichen sclerosus involving the vagina. Longinotti, M., Schieffer, Y.M., Kaufman, R.H. Obstetrics and gynecology. (2005) [Pubmed]
  24. Intrinsic potencies of novel thiol ester corticosteroids RS-85095 and RS-21314 as compared with clobetasol 17-propionate and fluocinonide. Ong, J.T., Poulsen, B.J., Akers, W.A., Scholtz, J.R., Genter, F.C., Kertesz, D.J. Archives of dermatology. (1989) [Pubmed]
  25. Somatostatin- and factor XIIIa-immunoreactive cells in psoriasis during clobetasol propionate and calciprotriol treatment. Talme, T., Schultzberg, M., Sundqvist, K.G., Marcusson, J.A. Acta Derm. Venereol. (1999) [Pubmed]
  26. Spectrophotometric determination of clobetasol propionate, halobetasol propionate, quinagolide hydrochloride, through charge transfer complexation. Mostafa, A.A., Bebawy, L.I., Refaat, H.H. Journal of pharmaceutical and biomedical analysis. (2002) [Pubmed]
  27. Systemic and topical corticosteroid treatment of oral lichen planus: a comparative study with long-term follow-up. Carbone, M., Goss, E., Carrozzo, M., Castellano, S., Conrotto, D., Broccoletti, R., Gandolfo, S. J. Oral Pathol. Med. (2003) [Pubmed]
  28. Strain differences in the induction of mono-oxygenase activity in mouse skin by topical clobetasol propionate: evidence of a role for the hr locus. Finnen, M.J., Herdman, M.L., Shuster, S. J. Steroid Biochem. (1985) [Pubmed]
  29. A double-blind randomized trial of 0.1% tacrolimus vs 0.05% clobetasol for the treatment of childhood vitiligo. Lepe, V., Moncada, B., Castanedo-Cazares, J.P., Torres-Alvarez, M.B., Ortiz, C.A., Torres-Rubalcava, A.B. Archives of dermatology. (2003) [Pubmed]
  30. Retinoic acid induces expression of PA-FABP (psoriasis-associated fatty acid-binding protein) gene in human skin in vivo but not in cultured skin cells. Larsen, F.G., Voorhees, J.J., Aström, A. Exp. Dermatol. (1994) [Pubmed]
  31. Lupus erythematosus profundus treated with clobetasol propionate under a hydrocolloid dressing. Yell, J.A., Burge, S.M. Br. J. Dermatol. (1993) [Pubmed]
  32. A new delivery system of clobetasol-17-propionate (lipid-loaded microspheres 0.025%) compared with a conventional formulation (lipophilic ointment in a hydrophilic phase 0.025%) in topical treatment of atrophic/erosive oral lichen planus. A Phase IV, randomized, observer-blinded, parallel group clinical trial. Campisi, G., Giandalia, G., De Caro, V., Di Liberto, C., Aricò, P., Giannola, L.I. Br. J. Dermatol. (2004) [Pubmed]
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