Disease relevance of Polyradiculopathy

• Gadolinium-enhanced MRI in a case of cytomegalovirus polyradiculopathy [1].
• A 22 year old woman with recently diagnosed systemic lupus erythematosus presented with subacute progressive areflexic paraparesis, electrophysiologically identified as a pure axonal polyradiculopathy [2].
• OBJECTIVES: To describe the abnormalities in CSF from HIV infected patients with acute lumbosacral polyradiculopathy (ALP) caused by cytomegalovirus (CMV) infection [3].
• All forms of neuromuscular disease have been reported, including axonal neuropathy, demyelinating neuropathy, mononeuropathy multiplex, polyradiculitis, ALS-like syndromes, disorders of neuromuscular transmission, myopathy, and toxic neuropathies due to medication side effects [4].
• Ganciclovir and foscarnet have improved the prognosis of multifocal neuropathy and polyradiculopathy, but response rates for encephalitis are low [5].

High impact information on Polyradiculopathy

• Ganciclovir for lumbosacral polyradiculopathy in AIDS [6].
• Ethylene glycol intoxication: electrophysiological studies suggest a polyradiculopathy [7].
• We report two cases of AIDS-related polyradiculopathy in which spinal T1-weighted MRI with gadolinium-DTPA showed enhancement of the pial lining of the conus medullaris, cauda equina, and lumbar nerve roots [8].
• The 2nd patient developed syphilitic polyradiculopathy and a positive CSF VDRL 3 months after treatment with IV penicillin [9].
• Vasculitic polyradiculopathy in systemic lupus erythematosus [2].

Chemical compound and disease context of Polyradiculopathy

• Cytomegalovirus polyradiculopathy treated successfully with foscarnet [10].
• A case of penicillamin-induced severe polyradiculopathy in rheumatoid arthritis is presented [11].

Anatomical context of Polyradiculopathy

• The most common of these are central nervous system (CNS) complications (Lind, 1979) including meningitis, encephalitis, cranial nerve palsies, ascending paralysis (Guillain-Barre-like), transverse myelitis, cerebellar ataxia, polyradiculitis and acute psychosis [12].

Gene context of Polyradiculopathy

• The highest activities were recorded in patients with leukaemia. uPA was not detected in the CSF of the patients with meningitis, facial paresis or polyradiculitis [13].
• A 25-year-old man with the skin lesions of malignant atrophic papulosis had clinical and electrodiagnostic evidence of a multifocal asymmetric myelomalacia or polyradiculopathy in association with elevated CSF protein and hypoglycorrhachia [14].
• Late cytomegalovirus polyradiculopathy following haploidentical CD34+-selected hematopoietic stem cell transplantation [15].
• We present a patient with NIDDM, subacute onset of painful asymmetric polyradiculopathy, and unilateral enhancement of lumbar nerve roots on MRI [16].
• Progressive polyradiculopathy usually occurs in patients with AIDS and low CD4 counts [17].

References