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MeSH Review

Brenner Tumor

 
 
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Disease relevance of Brenner Tumor

 

High impact information on Brenner Tumor

  • Focal expression of uroplakins was observed on the luminal surface of ovarian Brenner tumor cells forming microcysts in all 5 cases examined [3].
  • Considering the known source of estrogen production being tumor cells in certain cases of Brenner tumor, there seem to be two types of estrogen-producing Brenner tumors depending on the source of estrogen, i.e. tumor cells or stromal cells [4].
  • Immunohistochemical analysis of cytochromes P-450 aromatase and P-450 17 alpha-hydroxylase, which catalyze the production of estrogens and androgens, respectively, was performed for 23 cases of ovarian Brenner tumor [5].
  • Selective expression of cytokeratin polypeptides in various epithelia of human Brenner tumor [6].
  • Although the first Brenner tumor was reported in 1898 by MacNaughton-Jones, it was not until 1907 that Fritz Brenner described the tumor that bears his name [7].
 

Chemical compound and disease context of Brenner Tumor

 

Biological context of Brenner Tumor

 

Gene context of Brenner Tumor

  • CK-7 was present in all cases studied with the exception of one Walthard cell nest and a malignant Brenner tumor that was not immunoreactive with the other antibodies tested [11].
  • Brenner tumor, in this case, may produce thyroglobulin or have a receptor to thyroglobulin or analog of thyroglobulin [12].
  • Representative areas of two cases of malignant Brenner tumor were investigated by means of the peroxidase-antiperoxidase method using monoclonal antibody to CA125 and CA72-4 antigen and the streptavidin-biotin immunoperoxidase complex method using monoclonal antibody to SCC antigen [13].

References

  1. Localization of the steroidogenic acute regulatory protein in human tissues. Pollack, S.E., Furth, E.E., Kallen, C.B., Arakane, F., Kiriakidou, M., Kozarsky, K.F., Strauss, J.F. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  2. Leiomyomatosis peritonealis disseminata and ovarian Brenner tumor associated with tamoxifen use. Bristow, R.E., Montz, F.J. Int. J. Gynecol. Cancer (2001) [Pubmed]
  3. Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. Ogawa, K., Johansson, S.L., Cohen, S.M. Am. J. Pathol. (1999) [Pubmed]
  4. A case of estrogen-producing Brenner tumor with a stromal component as a potential source for estrogen. Hiroi, H., Osuga, Y., Tarumoto, Y., Shimokama, T., Yano, T., Yokota, H., Taketani, Y. Oncology (2002) [Pubmed]
  5. Brenner tumor of the ovary: immunoanalysis of steroidogenic enzymes in 23 cases. Sasano, H., Wargotz, E.S., Silverberg, S.G., Mason, J.I., Simpson, E.R. Hum. Pathol. (1989) [Pubmed]
  6. Selective expression of cytokeratin polypeptides in various epithelia of human Brenner tumor. Lifschitz-Mercer, B., Czernobilsky, B., Shezen, E., Dgani, R., Leitner, O., Geiger, B. Hum. Pathol. (1988) [Pubmed]
  7. Bilateral Brenner tumors: a case report and review of the literature. Lamping, J.D., Blythe, J.G. Hum. Pathol. (1977) [Pubmed]
  8. Magnetic resonance imaging of a benign Brenner tumor with an ipsilateral simple cyst. Ohara, N., Teramoto, K. Arch. Gynecol. Obstet. (2001) [Pubmed]
  9. Benign Brenner tumor of the ovary detected on Tc-99m methylene diphosphonate bone scan. Renner, J.B., McCartney, W.H. Clinical nuclear medicine. (1984) [Pubmed]
  10. Flow cytometric DNA analysis of ovarian Brenner tumors and transitional cell carcinomas. Martin, A.R., Kotylo, P.K., Kennedy, J.C., Fineberg, N.S., Roth, L.M. Int. J. Gynecol. Pathol. (1992) [Pubmed]
  11. Transitional cell neoplasms of the ovary and urinary bladder: a comparative immunohistochemical analysis. Soslow, R.A., Rouse, R.V., Hendrickson, M.R., Silva, E.G., Longacre, T.A. Int. J. Gynecol. Pathol. (1996) [Pubmed]
  12. Coexisting Brenner tumor and struma ovarii in the right ovary: case report and review of the literature. Yoshida, M., Obayashi, C., Tachibana, M., Minami, R. Pathol. Int. (2004) [Pubmed]
  13. Malignant Brenner tumors of the ovary and tumor markers: case reports. Yamamoto, R., Fujita, M., Kuwabara, M., Sogame, M., Ebina, Y., Sakuragi, N., Kato, H., Fujimoto, S. Jpn. J. Clin. Oncol. (1999) [Pubmed]
 
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