Disease relevance of Panuveitis

• ANCA antibodies were detected in 29% of all patients with panuveitis or anterior uveitis [1].
• OBJECTIVE: To review the safety and efficacy of cyclosporine in the treatment of children with severe bilateral sight-threatening intermediate uveitis or panuveitis [2].
• METHODS: Forty patients with chronic intermediate, posterior, or panuveitis associated cystoid macular edema were randomized into a masked, cross-over trial comparing acetazolamide versus placebo [3].
• There was a trend towards elevated levels of IL-10+ T cells in AH from patients with FHC compared with AH from acute uveitis and panuveitis patients [4].
• The prevalence of IgG anti-UACA autoantibodies in patients with panuveitis (Vogt-Koyanagi-Harada disease, Behçet's disease, sarcoidosis) was significantly higher than that in healthy controls (19.6-28.1% vs 0%, P < 0.05) indicating that autoimmunity directed against UACA is a common phenomenon in these diseases [5].

High impact information on Panuveitis

• Since tumour necrosis factor (TNF) might have an important pathogenetic role in Behçet's disease, we decided to give a single infusion of infliximab-a monoclonal antibody against TNF-to five patients with relapsing panuveitis, at the immediate onset of last relapse [6].
• IL-10 was higher in the panuveitis group on steroids (P < 0.01) [7].
• Increased IFN-gamma was detected in both AU and panuveitis groups compared with controls (P < 0.01) [7].
• The authors investigated whether an intravitreal sustained-release dexamethasone device was effective in the treatment of severe panuveitis in a rabbit model [8].
• Methotrexate treatment for sarcoid-associated panuveitis [9].

Chemical compound and disease context of Panuveitis

• RESULTS: Bilateral panuveitis was successfully treated with topical steroid [10].
• We report an unusual ocular presentation of HCL due to panuveitis with dramatic improvement following treatment with 2-chlorodeoxyadenosine (2-CdA) [11].
• RESULTS: After 7 months of treatment for bilateral panuveitis with topical steroid and tropicamide, the patient developed a thin, transparent membrane arising on the lens surface in the right eye [12].
• Labial adenocarcinoma after treatment with cyclosporin a in a patient with panuveitis [13].
• RESULTS: Manifest granulomatous panuveitis developed 2 months after the introduction of the protease inhibitor indinavir (CD4 rise from 2 to 64 CD4/mm3) and coincided with cicatrization of the CMV retinitis in the absence of efficient anti-CMV therapy [14].

Gene context of Panuveitis

• The levels of IL-6 did not correlate with a specific clinical diagnosis, but patients with pars planitis and panuveitis had the highest levels (p = 0.58) CONCLUSIONS: IL-6 is elevated in the vitreous of patients with active intermediate and posterior uveitis [15].
• Increased percentages of interleukin (IL)-10+-, but not interferon (IFN)-gamma+ T lymphocytes were found in AH compared with PB in patients with acute anterior uveitis (AAU), FHC or chronic panuveitis (PU) [4].
• Identification of a novel autoantigen UACA in patients with panuveitis [5].
• Bilateral panuveitis in a child with hypohidrotic ectodermal dysplasia [16].
• AIM: To study long term effects of interferon alpha 2a (IFN alpha 2a) on panuveitis in seven patients with Behçet's disease in a prospective, open clinical trial [17].

References