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Disease relevance of Panuveitis


High impact information on Panuveitis

  • Since tumour necrosis factor (TNF) might have an important pathogenetic role in Behçet's disease, we decided to give a single infusion of infliximab-a monoclonal antibody against TNF-to five patients with relapsing panuveitis, at the immediate onset of last relapse [6].
  • IL-10 was higher in the panuveitis group on steroids (P < 0.01) [7].
  • Increased IFN-gamma was detected in both AU and panuveitis groups compared with controls (P < 0.01) [7].
  • The authors investigated whether an intravitreal sustained-release dexamethasone device was effective in the treatment of severe panuveitis in a rabbit model [8].
  • Methotrexate treatment for sarcoid-associated panuveitis [9].

Chemical compound and disease context of Panuveitis


Gene context of Panuveitis


  1. pANCA antibodies in patients with anterior uveitis: identification of a marker antibody usually associated with ulcerative colitis. Gordon, L.K., Eggena, M., Holland, G.N., Weisz, J.M., Braun, J. J. Clin. Immunol. (1998) [Pubmed]
  2. Cyclosporine therapy for severe sight-threatening uveitis in children and adolescents. Walton, R.C., Nussenblatt, R.B., Whitcup, S.M. Ophthalmology (1998) [Pubmed]
  3. A randomized, masked, cross-over trial of acetazolamide for cystoid macular edema in patients with uveitis. Whitcup, S.M., Csaky, K.G., Podgor, M.J., Chew, E.Y., Perry, C.H., Nussenblatt, R.B. Ophthalmology (1996) [Pubmed]
  4. Intracellular T lymphocyte cytokine profiles in the aqueous humour of patients with uveitis and correlation with clinical phenotype. Hill, T., Galatowicz, G., Akerele, T., Lau, C.H., Calder, V., Lightman, S. Clin. Exp. Immunol. (2005) [Pubmed]
  5. Identification of a novel autoantigen UACA in patients with panuveitis. Yamada, K., Senju, S., Nakatsura, T., Murata, Y., Ishihara, M., Nakamura, S., Ohno, S., Negi, A., Nishimura, Y. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  6. Effect of infliximab on sight-threatening panuveitis in Behçet's disease. Sfikakis, P.P., Theodossiadis, P.G., Katsiari, C.G., Kaklamanis, P., Markomichelakis, N.N. Lancet (2001) [Pubmed]
  7. Multiplex cytokine detection versus ELISA for aqueous humor: IL-5, IL-10, and IFNgamma profiles in uveitis. Ooi, K.G., Galatowicz, G., Towler, H.M., Lightman, S.L., Calder, V.L. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  8. Intravitreal sustained-release dexamethasone device in the treatment of experimental uveitis. Cheng, C.K., Berger, A.S., Pearson, P.A., Ashton, P., Jaffe, G.J. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  9. Methotrexate treatment for sarcoid-associated panuveitis. Dev, S., McCallum, R.M., Jaffe, G.J. Ophthalmology (1999) [Pubmed]
  10. Bilateral panuveitis: a possible association with Kikuchi-Fujimoto disease. Taguri, A.H., McIlwaine, G.G. Am. J. Ophthalmol. (2001) [Pubmed]
  11. Panuveitis responsive to 2-CdA: an unusual ocular presentation of hairy cell leukemia. Zeidman, A., Floru, S., Robinson, A., Polliack, A., Djaldeti, M., Savir, H., Mittelman, M. Leuk. Lymphoma (1996) [Pubmed]
  12. True exfoliation of the lens capsule following uveitis. Yamamoto, N., Miyagawa, A. Graefes Arch. Clin. Exp. Ophthalmol. (2000) [Pubmed]
  13. Labial adenocarcinoma after treatment with cyclosporin a in a patient with panuveitis. Ramchandani, M., Brown, A.M., Rippin, J.W., Murray, P.I. Am. J. Ophthalmol. (2000) [Pubmed]
  14. Cicatrization of cytomegalovirus retinitis following introduction of highly active anti-retroviral therapy: uveitis as a possible indicator of good ocular prognosis. Herbort, C.P., Chave, J.P. Graefes Arch. Clin. Exp. Ophthalmol. (1998) [Pubmed]
  15. Elevated levels of interleukin 6 in the vitreous fluid of patients with pars planitis and posterior uveitis: the Massachusetts eye & ear experience and review of previous studies. Perez, V.L., Papaliodis, G.N., Chu, D., Anzaar, F., Christen, W., Foster, C.S. Ocul. Immunol. Inflamm. (2004) [Pubmed]
  16. Bilateral panuveitis in a child with hypohidrotic ectodermal dysplasia. Rodriguez, N., Eliott, D., Garcia-Valenzuela, E., Baker, J. Am. J. Ophthalmol. (2002) [Pubmed]
  17. Treatment of ocular symptoms of Behçet's disease with interferon alpha 2a: a pilot study. Kötter, I., Eckstein, A.K., Stübiger, N., Zierhut, M. The British journal of ophthalmology. (1998) [Pubmed]
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