Disease relevance of Uveitis, Anterior

• T cells infiltrating the iris/ciliary body of Lewis rats with anterior uveitis (AU) that had been induced by myelin basic protein (MBP) immunization were previously found to share surface markers common to the T cells that cause experimental autoimmune encephalomyelitis (EAE) [1].
• OBJECTIVE: To assess the efficacy of ciprofloxacin in the treatment of reactive arthritis (ReA) and anterior uveitis (AU) in a double-blind, randomized, placebo-controlled trial [2].
• Although human anterior uveitis has been historically characterized as a collagen disease, this is first time collagen has been directly identified as the target autoantigen in uveitis [3].
• To delineate the role played by MCP-1 in acute anterior uveitis, a common ocular inflammation, MCP-1(-/-) mice and wild-type matched control mice were analyzed for the development of endotoxin-induced uveitis (EIU) in response to subcutaneous injection of a sublethal dose of lipopolysaccharide (LPS) [4].
• PURPOSE: The purpose of this study was to determine levels of IL-2, -4, -5, -10, TNF-alpha, and IFN-gamma in aqueous humor (AH) from patients with active panuveitis, anterior uveitis (AU), and noninflammatory controls by using a flow cytometric mutiplex array (CBA) and to compare with results from ELISA [5].

High impact information on Uveitis, Anterior

• Anterior uveitis and ankylosing spondylitis [6].
• Anterior uveitis and alpha-1-antitrypsin [7].
• Decreased incidence of anterior uveitis in patients with ankylosing spondylitis treated with the anti-tumor necrosis factor agents infliximab and etanercept [8].
• Type I collagen is the autoantigen in experimental autoimmune anterior uveitis [3].
• These observations suggested that the down-modulation of these inflammatory genes by estrogen may contribute to the reduction in cellular infiltration in acute anterior uveitis [9].

Chemical compound and disease context of Uveitis, Anterior

• Footpad injection of bacterial lipopolysaccharide (LPS) causes pronounced anterior uveitis in susceptible species and strains [10].
• Effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate on experimentally induced autoimmune anterior uveitis [11].
• Measurable levels of C3a without detectable C4a in five patients with anterior uveitis suggested alternative pathway activation of complement [12].
• Severe anterior uveitis developed in Lewis rats injected with a neutralizing mAb against Crry, with increased formation of C3 split products [13].
• Eosinophil chemotaxis and anterior uveitis from topical dimaprit and nordimaprit [14].

Biological context of Uveitis, Anterior

• The alpha 1-antitrypsin phenotype MZ in acute anterior uveitis [15].
• The lifetime cumulative incidence of acute anterior uveitis in a normal population and its relation to ankylosing spondylitis and histocompatibility antigen HLA-B27 [16].
• Importance of cryptic myelin basic protein epitopes in the pathogenicity of acute and recurrent anterior uveitis associated with EAE [17].
• In contrast to its protective systemic effect in the mouse, constitutive secretion of IFN-gamma in the rat eye was found to predispose the development of severe anterior uveitis and induction of retinal degenerative processes that impair visual acuity [18].
• Clinical evaluation of clobetasone butyrate eye drops in the treatment of anterior uveitis and its effects on intraocular pressure [19].

Anatomical context of Uveitis, Anterior

• In aqueous humor from eyes with anterior uveitis, the authors were able to measure levels of C3a in all 14 patients, C4a in 9/14 patients, and C5a in 5/14 patients [12].
• Inflammatory mediator modulation of ocular FKN expression suggests that this adhesive chemokine may play important roles in regulating leukocyte efflux in inflammatory eye diseases, such as anterior uveitis and retinochoroiditis [20].
• PARTICIPANTS: Seven consecutive patients with acute onset of HLA B27-associated anterior uveitis, with at least three anterior chamber cells [21].
• Similar pattern of MCP-1 expression in spinal cords and eyes of Lewis rats with experimental autoimmune encephalomyelitis associated anterior uveitis [22].
• The purpose of this study is to investigate the sequential expression of certain chemokines and chemokine receptors in the iris-ciliary body and popliteal lymph nodes of Lewis rats and, thus, to establish their roles in experimental autoimmune anterior uveitis [23].

Gene context of Uveitis, Anterior

• MCP-1 may be a new therapeutic strategy for acute anterior uveitis [4].
• PURPOSE: To study the role of costimulatory signaling through the CD28-B7 interaction in experimental autoimmune anterior uveitis (EAAU) [24].
• HLA-B 27 was found to be associated with 43% of cases of acute anterior uveitis without systemic disease [25].
• CONCLUSIONS: This is the first study of chemokine concentrations in the aqueous humor of patients with acute anterior uveitis [26].
• It is likely that pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 alpha (IL-1 alpha), which are known modulators of MMPs, induce their secretion in acute anterior uveitis [27].

Analytical, diagnostic and therapeutic context of Uveitis, Anterior

• Varicella-zoster virus-induced anterior uveitis was diagnosed by polymerase chain reaction methods and serum antibody titration [28].
• Simultaneous detection of vitamin C and uric acid by capillary electrophoresis in plasma of diabetes and in aqueous humor in acute anterior uveitis [29].
• Of 69 patients with other causes of arthritis who were followed in parallel as a control group, four of 15 patients with early onset pauciarticular juvenile rheumatoid arthritis had chronic anterior uveitis and two of 12 patients with juvenile spondyloarthropathy had acute anterior uveitis [30].
• Serum alpha-1 acid glycoprotein levels were measured in 56 patients with acute idiopathic anterior uveitis and 42 healthy subjects by a radial immunodiffusion method [31].
• METHODS: The expression of Fas and FasL on peripheral blood T lymphocytes was determined using flow cytometry in 26 patients with Behcet's disease (BD), 17 patients with VKH syndrome, 25 patients with idiopathic anterior uveitis, and 43 healthy individuals (controls) [32].

References