Disease relevance of thioridazine

• Thioridazine (Mellaril) hydrochloride cardiotoxicity is manifested by bradycardia and prolongation of the QT interval [1].
• A case of allergic rash associated with malignant hyperthermia (body temperature of 41 C) occurred in a patient who had been taking 400 mg of thioridazine hydrochloride (Mellaril) daily for two days [2].
• We present 4 patients seen in the last 5 years who had taken thioridazine (Mellaril) prior to development of priapism [3].
• The effects of therapeutic and toxic doses of thioridazine (Mellaril) (10 and 50 mg/kg body weight, respectively) on ventricular electrophysiologic properties were studied in 12 anesthetized dogs [4].
• Although most patients were receiving several drugs, Mellaril (thioridazine) appeared to be responsible for five cases of ventricular tachycardia, one of which was fatal in a 35 year old woman [5].

High impact information on thioridazine

• All patients with cataracts were middle-aged or had a history of severe self-induced trauma or treatment with high dosages of thioridazine hydrochloride [6].
• Observations on the acoustic reflex threshold in institutionalized retarded adults taking mellaril and/or thorazine [7].
• In this open pilot study, bromocriptine mesylate (Parlodel, Sandoz) was administered in an escalating dose schedule to 11 stabilized psychiatric outpatients with hyperprolactinemia resulting from thioridazine HCl (Mellaril, Sandoz) treatment [8].
• The mutagenic effects of thioridazine hydrochloride were studied in Swiss albino mice [9].
• Cytogenetic effect of thioridazine hydrochloride in mice and in human lymphocyte chromosomes [9].

Chemical compound and disease context of thioridazine

• The first patient was a 56-year-old schizophrenic man receiving thioridazine hydrochloride, trifluoperazine hydrochloride, and benztropine mesylate who was admitted to a hospital after a syncopal episode [10].

Anatomical context of thioridazine

• The animals were treated with 4, 6 and 8 mg/kg of thioridazine hydrochloride for the micronucleus test, analysis of chromosomes in germ cells, and for sperm morphology assay [9].

Associations of thioridazine with other chemical compounds

• Thioridazine (Mellaril) medication was discontinued for 4 to 5 weeks for 106 institutionalized mentally retarded patients after an extended period of previous drug treatment [11].

Gene context of thioridazine

• Human lymphocyte cultures were treated in vitro with 0.75, 1.25 and 1.75 mg/culture of thioridazine hydrochloride for 24, 48 and 72 hours [9].

Analytical, diagnostic and therapeutic context of thioridazine

• Influence of processing on the stability and release properties of biodegradable microspheres containing thioridazine hydrochloride [12].
• Chemiluminescence determination of thioridazine hydrochloride by flow-injection analysis [13].

References