The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Orphan Drug Production

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Orphan Drug Production

 

High impact information on Orphan Drug Production

  • Preclinical and clinical evidence now indicate that meso-2,3-dimercaptosuccinic acid, an Orphan Drug, shows the most promise for being effective in this regard [6].
  • Dornase-alfa and orphan drugs [7].
  • Lithium: an orphan drug [8].
  • The federal Interagency Task Force on Drugs of Limited Commercial Value recommendations propose initiation of a wide spectrum of administrative and legislative changes; these are designed to create incentives for industry to cooperate with government in developing and making orphan drugs available to those who need them [9].
  • As a true "orphan drug" developed to treat a very small patient population, the cost per patient of PEG-ADA is very high [10].
 

Chemical compound and disease context of Orphan Drug Production

 

Associations of Orphan Drug Production with chemical compounds

 

Gene context of Orphan Drug Production

  • METHODS: Information about orphan drug designation and approval was obtained from the website of the European Commission-Enterprise and Industry DG and from the European Public Assessment Reports. RESULTS: Out of 255 OMP designations, only 18 were approved (7.1%) [16].
  • Orphan drugs and the NHS: should we value rarity [17]?
  • CMS move threatens to put orphan drugs out in cold [18].
  • The kallikrein inhibitor DX-88 (Dyax) has received orphan drug status in Europe and is undergoing clinical trial in Europe and the USA [19].

References

  1. A cost-effectiveness analysis of the orphan drug cysteamine in the treatment of infantile cystinosis. Soohoo, N., Schneider, J.A., Kaplan, R.M. Medical decision making : an international journal of the Society for Medical Decision Making. (1997) [Pubmed]
  2. Analysis of D-penicillamine by gas chromatography utilizing nitrogen--phosphorus detection. Rushing, L.G., Hansen, E.B., Thompson, H.C. J. Chromatogr. (1985) [Pubmed]
  3. 3,4-Diaminopyridine, an orphan drug, in the symptomatic treatment of Lambert-Eaton myasthenic syndrome. Molgó, J., Guglielmi, J.M. Pflugers Arch. (1996) [Pubmed]
  4. Development of an orphan drug by a start-up company. MetroGel for rosacea. Borgman, R.J. International journal of technology assessment in health care. (1992) [Pubmed]
  5. Gleevec for the treatment of chronic myelogenous leukemia: US. Food and Drug Administration regulatory mechanisms, accelerated approval, and orphan drug status. Cohen, M.H., Moses, M.L., Pazdur, R. Oncologist (2002) [Pubmed]
  6. meso-2,3-Dimercaptosuccinic acid: chemical, pharmacological and toxicological properties of an orally effective metal chelating agent. Aposhian, H.V., Aposhian, M.M. Annu. Rev. Pharmacol. Toxicol. (1990) [Pubmed]
  7. Dornase-alfa and orphan drugs. Collier, J. Lancet (1995) [Pubmed]
  8. Lithium: an orphan drug. Rosenthal, N.E. Arch. Gen. Psychiatry (2001) [Pubmed]
  9. Orphan drugs: creating a policy. Asbury, C.H., Stolley, P.D. Ann. Intern. Med. (1981) [Pubmed]
  10. PEG-ADA: an alternative to haploidentical bone marrow transplantation and an adjunct to gene therapy for adenosine deaminase deficiency. Hershfield, M.S. Hum. Mutat. (1995) [Pubmed]
  11. Topical metronidazole: a new therapy for rosacea. Schmadel, L.K., McEvoy, G.K. Clinical pharmacy. (1990) [Pubmed]
  12. Glycoprotein pharmaceuticals: scientific and regulatory considerations, and the US Orphan Drug Act. Liu, D.T. Trends Biotechnol. (1992) [Pubmed]
  13. Allergic reactions to Triatoma bites. Moffitt, J.E., Venarske, D., Goddard, J., Yates, A.B., deShazo, R.D. Ann. Allergy Asthma Immunol. (2003) [Pubmed]
  14. Methadone: an orphan drug? Ripamonti, C., Bianchi, M., Bruera, E. Journal of palliative medicine. (2004) [Pubmed]
  15. Imatinib. Novartis. Radford, I.R. Current opinion in investigational drugs (London, England : 2000) (2002) [Pubmed]
  16. Orphan drug development is progressing too slowly. Joppi, R., Bertele, V., Garattini, S. British journal of clinical pharmacology. (2006) [Pubmed]
  17. Orphan drugs and the NHS: should we value rarity? McCabe, C., Claxton, K., Tsuchiya, A. BMJ (2005) [Pubmed]
  18. CMS move threatens to put orphan drugs out in cold. Carroll, J. Managed care (Langhorne, Pa.) (2003) [Pubmed]
  19. Protease inhibitors in the treatment of hereditary angioedema. Ritchie, B.C. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis. (2003) [Pubmed]
 
WikiGenes - Universities