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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Rosacea


Psychiatry related information on Rosacea


High impact information on Rosacea


Chemical compound and disease context of Rosacea


Biological context of Rosacea


Anatomical context of Rosacea


Gene context of Rosacea

  • The 84-kDa active form of gelatinase B was observed in 46% of the rosacea tear samples and none of the controls [9].
  • CONCLUSIONS: Concentrations of IL-1alpha are present in normal tears but are elevated in ocular rosacea, whereas TNF-alpha is not present in either case [20].
  • There also was a 3.5-fold increase of the CD4/CD8 ratio in the rosacea conjunctival stroma compared with the normal specimens [21].
  • From these results we suggest that, (a) ligands of the VIP-R may contribute to vascular and dermal alterations in rosacea and (b) immature sebocytes show an unusual antigen expression of S100A and glandular keratin [22].
  • Retinoids may modulate VEGF in skin and this may be related to an effect on rosacea [23].
  • In mice, injection of the cathelicidin peptides found in rosacea, addition of SCTE, and increasing protease activity by targeted deletion of the serine protease inhibitor gene Spink5 each increases inflammation in mouse skin [24].

Analytical, diagnostic and therapeutic context of Rosacea


  1. The retinoids. A review of their clinical pharmacology and therapeutic use. Orfanos, C.E., Ehlert, R., Gollnick, H. Drugs (1987) [Pubmed]
  2. Steroid rosacea in children. Franco, H.L., Weston, W.L. Pediatrics (1979) [Pubmed]
  3. Keratitis, ulceration, and perforation associated with topical nonsteroidal anti-inflammatory drugs. Guidera, A.C., Luchs, J.I., Udell, I.J. Ophthalmology (2001) [Pubmed]
  4. A comparison of 15% azelaic acid gel and 0.75% metronidazole gel in the topical treatment of papulopustular rosacea: results of a randomized trial. Elewski, B.E., Fleischer, A.B., Pariser, D.M. Archives of dermatology. (2003) [Pubmed]
  5. A follow-up of tetracycline-treated rosacea. With special reference to rosacea keratitis. Knight, A.G., Vickers, C.F. Br. J. Dermatol. (1975) [Pubmed]
  6. Treatment of the facial angiofibromas of tuberous sclerosis. Verheyden, C.N. Plast. Reconstr. Surg. (1996) [Pubmed]
  7. Treatment of rosacea by metronidazole. Pye, R.J., Burton, J.L. Lancet (1976) [Pubmed]
  8. Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant. Sobrin, L., Liu, Z., Monroy, D.C., Solomon, A., Selzer, M.G., Lokeshwar, B.L., Pflugfelder, S.C. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  9. Tear fluid gelatinase B activity correlates with IL-1alpha concentration and fluorescein clearance in ocular rosacea. Afonso, A.A., Sobrin, L., Monroy, D.C., Selzer, M., Lokeshwar, B., Pflugfelder, S.C. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  10. Oral thermal-induced flushing in erythematotelangiectatic rosacea. Wilkin, J.K. J. Invest. Dermatol. (1981) [Pubmed]
  11. Diagnosis and treatment of ocular rosacea. Brown, S.I., Shahinian, L. Ophthalmology (1978) [Pubmed]
  12. Minocycline-induced scleral pigmentation. Fraunfelder, F.T., Randall, J.A. Ophthalmology (1997) [Pubmed]
  13. Comparison of the long-pulse dye (590-595 nm) and KTP (532 nm) lasers in the treatment of facial and leg telangiectasias. West, T.B., Alster, T.S. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (1998) [Pubmed]
  14. ABC of dermatology. Acne and rosacea. Buxton, P.K. British medical journal (Clinical research ed.) (1988) [Pubmed]
  15. Seasonal variation of dermatologic disease in the USA: a study of office visits from 1990 to 1998. Hancox, J.G., Sheridan, S.C., Feldman, S.R., Fleischer, A.B. International journal of dermatology. (2004) [Pubmed]
  16. Flow cytometric analysis of conjunctival epithelium in ocular rosacea and keratoconjunctivitis sicca. Pisella, P.J., Brignole, F., Debbasch, C., Lozato, P.A., Creuzot-Garcher, C., Bara, J., Saiag, P., Warnet, J.M., Baudouin, C. Ophthalmology (2000) [Pubmed]
  17. Health effects of sunlight exposure in the United States. Results from the first National Health and Nutrition Examination Survey, 1971-1974. Engel, A., Johnson, M.L., Haynes, S.G. Archives of dermatology. (1988) [Pubmed]
  18. Rhinophyma's fibrous variant. Histopathology and immunohistochemistry. Tope, W.D., Sangueza, O.P. The American Journal of dermatopathology. (1994) [Pubmed]
  19. The proposed inflammatory pathophysiology of rosacea: implications for treatment. Millikan, L. Skinmed. (2003) [Pubmed]
  20. Inflammatory cytokines in the tears of patients with ocular rosacea. Barton, K., Monroy, D.C., Nava, A., Pflugfelder, S.C. Ophthalmology (1997) [Pubmed]
  21. Ocular rosacea. A histologic and immunopathologic study. Hoang-Xuan, T., Rodriguez, A., Zaltas, M.M., Rice, B.A., Foster, C.S. Ophthalmology (1990) [Pubmed]
  22. Rhinophyma--unusual expression of simple-type keratins and S100A in sebocytes and abundance of VIP receptor-positive dermal cells. Wollina, U. Histol. Histopathol. (1996) [Pubmed]
  23. Inhibitory effects of retinoids on vascular endothelial growth factor production by cultured human skin keratinocytes. Lachgar, S., Charvéron, M., Gall, Y., Bonafé, J.L. Dermatology (Basel) (1999) [Pubmed]
  24. Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Yamasaki, K., Di Nardo, A., Bardan, A., Murakami, M., Ohtake, T., Coda, A., Dorschner, R.A., Bonnart, C., Descargues, P., Hovnanian, A., Morhenn, V.B., Gallo, R.L. Nat. Med. (2007) [Pubmed]
  25. Treatment of rosacea with i% metronidazole cream. A double-blind study. Nielsen, P.G. Br. J. Dermatol. (1983) [Pubmed]
  26. The relapse rate for rosacea after treatment with either oral tetracycline or metronidazole cream. Nielsen, P.G. Br. J. Dermatol. (1983) [Pubmed]
  27. Tenascin-C expression in normal, inflamed, and scarred human corneas. Maseruka, H., Bonshek, R.E., Tullo, A.B. The British journal of ophthalmology. (1997) [Pubmed]
  28. Comparison of tear function tests and impression cytology with the ocular findings in acne rosacea. Yaylali, V., Ozyurt, C. European journal of ophthalmology. (2002) [Pubmed]
  29. Ectropion secondary to bolus injection of 5-fluorouracil. Reeder, R.E., Mika, R.O. Optometry (St. Louis, Mo.) (2001) [Pubmed]
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