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MeSH Review

Lambert-Eaton Myasthenic Syndrome

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Disease relevance of Lambert-Eaton Myasthenic Syndrome


High impact information on Lambert-Eaton Myasthenic Syndrome


Chemical compound and disease context of Lambert-Eaton Myasthenic Syndrome


Biological context of Lambert-Eaton Myasthenic Syndrome


Anatomical context of Lambert-Eaton Myasthenic Syndrome


Gene context of Lambert-Eaton Myasthenic Syndrome


Analytical, diagnostic and therapeutic context of Lambert-Eaton Myasthenic Syndrome


  1. Paraneoplastic myasthenic syndrome IgG inhibits 45Ca2+ flux in a human small cell carcinoma line. Roberts, A., Perera, S., Lang, B., Vincent, A., Newsom-Davis, J. Nature (1985) [Pubmed]
  2. Antagonism of voltage-gated calcium channels in small cell carcinomas of patients with and without Lambert-Eaton myasthenic syndrome by autoantibodies omega-conotoxin and adenosine. De Aizpurua, H.J., Lambert, E.H., Griesmann, G.E., Olivera, B.M., Lennon, V.A. Cancer Res. (1988) [Pubmed]
  3. New Purkinje cell antibody (PCA-2): marker of lung cancer-related neurological autoimmunity. Vernino, S., Lennon, V.A. Ann. Neurol. (2000) [Pubmed]
  4. Treatment with oral 4-aminopyridine in disorders of neuromuscular transmission. Murray, N.M., Newsom-Davis, J. Neurology (1981) [Pubmed]
  5. Antibodies in sera from patients with myasthenia gravis do not bind to nicotinic acetylcholine receptors from human brain. Whiting, P.J., Cooper, J., Lindstrom, J.M. J. Neuroimmunol. (1987) [Pubmed]
  6. 3,4-Diaminopyridine in the treatment of Lambert-Eaton myasthenic syndrome. McEvoy, K.M., Windebank, A.J., Daube, J.R., Low, P.A. N. Engl. J. Med. (1989) [Pubmed]
  7. Autoimmunity to the voltage-gated calcium channel underlies the Lambert-Eaton myasthenic syndrome, a paraneoplastic disorder. Vincent, A., Lang, B., Newsom-Davis, J. Trends Neurosci. (1989) [Pubmed]
  8. The synaptic vesicle protein synaptotagmin associates with calcium channels and is a putative Lambert-Eaton myasthenic syndrome antigen. Leveque, C., Hoshino, T., David, P., Shoji-Kasai, Y., Leys, K., Omori, A., Lang, B., el Far, O., Sato, K., Martin-Moutot, N. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  9. Passive transfer of Lambert-Eaton myasthenic syndrome with IgG from man to mouse depletes the presynaptic membrane active zones. Fukunaga, H., Engel, A.G., Lang, B., Newsom-Davis, J., Vincent, A. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  10. Reduction of calcium currents by Lambert-Eaton syndrome sera: motoneurons are preferentially affected, and L-type currents are spared. García, K.D., Beam, K.G. J. Neurosci. (1996) [Pubmed]
  11. Eaton-Lambert myasthenic syndrome: long-term treatment of three patients with prednisone. Streib, E.W., Rothner, A.D. Ann. Neurol. (1981) [Pubmed]
  12. Synaptotagmin can cause an immune-mediated model of Lambert-Eaton myasthenic syndrome in rats. Takamori, M., Hamada, T., Komai, K., Takahashi, M., Yoshida, A. Ann. Neurol. (1994) [Pubmed]
  13. Guanidine and germine in Eaton-Lambert syndrome. Cherington, M. Neurology (1976) [Pubmed]
  14. Treatment of Lambert-Eaton syndrome: 3,4-diaminopyridine and pyridostigmine. Lundh, H., Nilsson, O., Rosén, I. Neurology (1984) [Pubmed]
  15. Edrophonium test in Eaton-Lambert syndrome: quantitative oculography. Dell'Osso, L.F., Ayyar, D.R., Daroff, R.B., Abel, L.A. Neurology (1983) [Pubmed]
  16. Recombinant calcium channel is recognized by Lambert-Eaton myasthenic syndrome antibodies. Iwasa, K., Takamori, M., Komai, K., Mori, Y. Neurology (2000) [Pubmed]
  17. Humoral immunity against glutamic acid decarboxylase and tyrosine phosphatase IA-2 in Lambert-Eaton myasthenic syndrome. Hermitte, L., Martin-Moutot, N., Boucraut, J., Barone, R., Atlan-Gepner, C., Seagar, M., Pouget, J., Kleisbauer, J.P., Couraud, F., Vialettes, B. J. Clin. Immunol. (2000) [Pubmed]
  18. Immunogenicity of P/Q-type calcium channel in small cell lung cancer: investigation of alpha1 subunit polyglutamine expansion. Black, J.L., Nelson, T.R., Snow, K., Lennon, V.A. Tissue Antigens (1999) [Pubmed]
  19. Treatment for Lambert-Eaton myasthenic syndrome. Maddison, P., Newsom-Davis, J. Cochrane database of systematic reviews (Online) (2005) [Pubmed]
  20. Lambert-Eaton myasthenic syndrome: clinical diagnosis, immune-mediated mechanisms, and update on therapies. Sanders, D.B. Ann. Neurol. (1995) [Pubmed]
  21. Presynaptic neuronal antigens expressed by a small cell lung carcinoma cell line. Benatar, M., Blaes, F., Johnston, I., Wilson, K., Vincent, A., Beeson, D., Lang, B. J. Neuroimmunol. (2001) [Pubmed]
  22. Lambert-Eaton syndrome: antigen-antibody interaction and calcium current inhibition in chromaffin cells. Viglione, M.P., Creutz, C.E., Kim, Y.I. Muscle Nerve (1992) [Pubmed]
  23. Serum and plasma from patients with Lambert-Eaton Myasthenic Syndrome reduce depolarization-dependent uptake of 45Ca2+ into rat cortical synaptosomes. Hewett, S.J., Atchison, W.D. Brain Res. (1991) [Pubmed]
  24. High innate production of interleukin-10 and tumor necrosis factor-alpha contributes to susceptibility for non-paraneoplastic Lambert-Eaton myasthenic syndrome. Wirtz, P.W., Huizinga, T.W., Stoeken, D.J., Wintzen, A.R., Verschuuren, J.J. J. Neuroimmunol. (2003) [Pubmed]
  25. Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen. Rosenfeld, M.R., Wong, E., Dalmau, J., Manley, G., Posner, J.B., Sher, E., Furneaux, H.M. Ann. Neurol. (1993) [Pubmed]
  26. Amyotrophic lateral sclerosis patient antibodies label Ca2+ channel alpha 1 subunit. Kimura, F., Smith, R.G., Delbono, O., Nyormoi, O., Schneider, T., Nastainczyk, W., Hofmann, F., Stefani, E., Appel, S.H. Ann. Neurol. (1994) [Pubmed]
  27. HLA and smoking in prediction and prognosis of small cell lung cancer in autoimmune Lambert-Eaton myasthenic syndrome. Wirtz, P.W., Willcox, N., van der Slik, A.R., Lang, B., Maddison, P., Koeleman, B.P., Giphart, M.J., Wintzen, A.R., Roep, B.O., Verschuuren, J.J. J. Neuroimmunol. (2005) [Pubmed]
  28. Lambert Eaton syndrome: autonomic neuropathy and inappropriate antidiuretic hormone secretion in a patient with small cell carcinoma of the lung. Manji, H., Schwartz, M.S., McKeran, R.O. J. Neurol. (1990) [Pubmed]
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