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Chemical Compound Review

Sectral     N-[3-ethanoyl-4-[2-hydroxy-3- (propan-2...

Synonyms: Neptal, acebutolol, Acebutololo, Prent, Acebutololum, ...
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Disease relevance of Acetobutolol


Psychiatry related information on Acetobutolol


High impact information on Acetobutolol


Chemical compound and disease context of Acetobutolol


Biological context of Acetobutolol


Anatomical context of Acetobutolol

  • The hemodynamic dose-response effects of intravenous acebutolol, a cardioselective beta-adrenoceptor antagonist with intrinsic sympathomimetic activity, were evaluated in 12 male subjects with angiographically confirmed coronary artery disease [24].
  • Compared with control measurements at rest after saline solution injection, these plasma concentrations of acebutolol resulted in a quadratic reduction in heart rate (maximum delta HR, -4 bpm) and a linear increase in pulmonary artery occluded pressure (maximum delta PAOP, +3 mm Hg) without change in systemic arterial pressure [24].
  • Direct effect of acebutolol on force generation in immature and adult myocardium [25].
  • The effect of acebutolol on active isometric force generation has been studied in isolated papillary muscle preparations from adult cats and kittens less than 24 h old [25].
  • Acebutolol-induced changes in refractoriness and monophastic action potential of the right ventricle of the dog heart in situ [26].

Associations of Acetobutolol with other chemical compounds


Gene context of Acetobutolol


Analytical, diagnostic and therapeutic context of Acetobutolol


  1. Cutaneous vasculitis due to acebutolol. Ashford, R., Staughton, R., Brighton, W.D. Lancet (1977) [Pubmed]
  2. Acebutolol-induced pleuropulmonary lupus syndrome. Record, N.B. Ann. Intern. Med. (1981) [Pubmed]
  3. Hepatic toxicity after acebutolol therapy. Tanner, L.A., Bosco, L.A., Zimmerman, H.J. Ann. Intern. Med. (1989) [Pubmed]
  4. Acebutolol therapy for ventricular arrhythmia. A randomized placebo-controlled double-blind multicenter study. De Soyza, N., Shapiro, W., Chandraratna, P.A., Aronow, W.S., Laddu, A.R., Thompson, C.H. Circulation (1982) [Pubmed]
  5. Effects of acebutolol on myocardial infarct extension: a randomized electrocardiographic, enzymatic and angiographic study. Azancot, I., Lorente, P., Georgiopoulos, G., Beaufils, P., Masquet, C., Baudouy, Y., Slama, R. Circulation (1982) [Pubmed]
  6. The psychological side effects of acebutolol and atenolol. Lewis, M.J., Jones, D.M., Dart, A.M., Henderson, A.H. British journal of clinical pharmacology. (1984) [Pubmed]
  7. Comparison of effect on psychomotor performance of single doses of propranolol and acebutolol. Broadhurst, A.D. Current medical research and opinion. (1980) [Pubmed]
  8. A randomized crossover comparison of acebutolol and methyldopa in the treatment of mild to moderate essential hypertension. Chatterji, A.N. Current medical research and opinion. (1978) [Pubmed]
  9. An antiidiotypic antibody that recognizes the beta-adrenergic receptor. Homcy, C.J., Rockson, S.G., Haber, E. J. Clin. Invest. (1982) [Pubmed]
  10. Cardiac and pulmonary effects of acebutolol. Kumana, C.R., Kaye, C.M., Leighton, M., Turner, P., Hamer, J. Lancet (1975) [Pubmed]
  11. Hemodynamic and beta-adrenergic receptor adaptations during long-term beta-adrenoceptor blockade. Studies with acebutolol, atenolol, pindolol, and propranolol in hypertensive patients. van den Meiracker, A.H., Man in't Veld, A.J., Boomsma, F., Fischberg, D.J., Molinoff, P.B., Schalekamp, M.A. Circulation (1989) [Pubmed]
  12. Effects of acebutolol on chronic stable angina pectoris. A placebo-controlled, double-blind, randomized crossover study. DiBianco, R., Singh, S., Singh, J.B., Katz, R.J., Bortz, R., Gottdiener, J.S., Spodick, D.H., Laddu, A.R., Fletcher, R.D. Circulation (1980) [Pubmed]
  13. Suppression of premature ventricular contractions by acebutolol. Gradman, A.H., Winkle, R.A., Fitzgerald, J.W., Meffin, P.J., Stoner, J., Bell, P.A., Harrison, D.C. Circulation (1977) [Pubmed]
  14. Clonidine, acebutolol and their interaction in essential hypertension: effects on blood pressure and the control of water and electrolyte balance. Plouin, P.F., Degoulet, P., Fermé, I., Cornette, M., Ménard, J. Eur. Heart J. (1983) [Pubmed]
  15. Multicentre study of the efficacy and tolerance of acebutolol versus atenolol in the long term treatment of mild arterial hypertension. De Backer, G. Drugs (1988) [Pubmed]
  16. Double-blind trial of the long-term effects of acebutolol and propranolol on serum lipoproteins in patients with stable angina pectoris. Miller, N.E., Nanjee, M.N., Rajput-Williams, J., Coltart, D.J. Am. Heart J. (1987) [Pubmed]
  17. Combined acebutolol/nifedipine therapy in patients with chronic coronary artery disease: additional improvement of ischemia-induced left ventricular dysfunction. Pfisterer, M., Müller-Brand, J., Burkart, F. Am. J. Cardiol. (1982) [Pubmed]
  18. Controlled trials with beta blockers in heart failure: metoprolol as the prototype. Fowler, M.B. Am. J. Cardiol. (1993) [Pubmed]
  19. Rapid identification of patients with essential hypertension sensitive to acebutolol (a new cardioselective beta-blocker). Menard, J., Bertagna, X., N'Guyen, P.T., Degoulet, P., Corvol, P. Am. J. Med. (1976) [Pubmed]
  20. Observations on the pharmacokinetics of acebutolol. Kaye, C.M., Kumana, C.R., Leighton, M., Hamer, J., Turner, P. Clin. Pharmacol. Ther. (1976) [Pubmed]
  21. Effects of beta blockade with acebutolol on hypertension, hemodynamics, and fluid volume. Dreslinski, G.R., Aristimuno, G.G., Messerli, F.H., Suarez, D.H., Frohlich, E.D. Clin. Pharmacol. Ther. (1979) [Pubmed]
  22. The effect of nitroglycerin, beta-blockade with acebutolol and isometric stress on incoordinate left ventricular function. Hall, R.J., Doran, J., Pusey, C., McHaffie, D., Gibson, D.G. Eur. Heart J. (1982) [Pubmed]
  23. Circulatory effects of intravenous and oral acebutolol in acute myocardial infarction. Silke, B., Nelson, G., Verma, S.P., Clarke, J., Baliga, G., Taylor, S.H. Clin. Pharmacol. Ther. (1985) [Pubmed]
  24. Dose-response effects of cardioselective beta blockade in coronary artery disease. Silke, B., Nelson, G., Hussain, M., Verma, S.P., Taylor, S.H. Clin. Pharmacol. Ther. (1984) [Pubmed]
  25. Direct effect of acebutolol on force generation in immature and adult myocardium. Sheridan, D., Tynan, M. Cardiovasc. Res. (1977) [Pubmed]
  26. Acebutolol-induced changes in refractoriness and monophastic action potential of the right ventricle of the dog heart in situ. Amlie, J.P., Refsum, H., Landmark, K. Cardiovasc. Res. (1978) [Pubmed]
  27. Glucose and lipid metabolism during acebutolol and propranolol therapy of angina in nondiabetic patients. Birnbaum, J., DiBianco, R., Becker, K.L., Muesing, R., Costello, R.B., Singh, S.N., Gottdiener, J.S., Fletcher, R.D. Clin. Pharmacol. Ther. (1983) [Pubmed]
  28. Calcium entry blockade or beta-blockade in long-term management of hypertension in blacks. M'Buyamba-Kabangu, J.R., Fagard, R., Lijnen, P., Staessen, J., Lissens, W., Ditu, M., Lepira, B., Tshiani, K.A., Amery, A. Clin. Pharmacol. Ther. (1987) [Pubmed]
  29. Survival following massive overdose of adrenergic blocking agents (acebutolol and labetalol). Lewis, M., Kallenbach, J., Germond, C., Zaltzman, M., Muller, F., Steyn, J., Zwi, S. Eur. Heart J. (1983) [Pubmed]
  30. The influence of intrinsic sympathomimetic activity and beta-1 receptor selectivity on the recovery of finger skin temperature after finger cooling in normotensive subjects. Lenders, J.W., Salemans, J., de Boo, T., Lemmens, W.A., Thien, T., van't Laar, A. Clin. Pharmacol. Ther. (1986) [Pubmed]
  31. Involvement of beta 2-adrenoceptor blockade and 5-hydroxytryptamine mechanism in inhibition of harmaline-induced tremors in rats. Paul, V. Eur. J. Pharmacol. (1986) [Pubmed]
  32. Selectivity of acebutolol, atenolol, and metoprolol in healthy volunteers estimated by the extent the drugs occupy beta 2-receptors in the circulating plasma. Kaila, T., Iisalo, E. Journal of clinical pharmacology. (1993) [Pubmed]
  33. Efficacy of acebutolol after acute myocardial infarction (the APSI trial). The APSI Investigators. Boissel, J.P., Leizorovicz, A., Picolet, H., Ducruet, T. Am. J. Cardiol. (1990) [Pubmed]
  34. Comparative effects of bisoprolol and acebutolol in smokers with airway obstruction. Macquin-Mavier, I., Roudot-Thoraval, F., Clerici, C., George, C., Harf, A. British journal of clinical pharmacology. (1988) [Pubmed]
  35. Dose-dependent acebutolol disposition after oral administration. Meffin, P.J., Winkle, R.A., Peters, F.A., Harrison, D.C. Clin. Pharmacol. Ther. (1978) [Pubmed]
  36. Acebultolol: basis for the prediction of effect on exercise tolerance. Biron, P., Tremblay, G. Clin. Pharmacol. Ther. (1976) [Pubmed]
  37. Acebutolol and left ventricular function: assessment by radionuclide angiography. Katz, R.J., DiBianco, R., Singh, S., Bortz, R., Bates, H.R., Sauerbrunn, B., Laddu, A.R., Fletcher, R.D. Clin. Pharmacol. Ther. (1981) [Pubmed]
  38. Prevention of postischaemic ventricular fibrillation by long term beta adrenoceptor blockade with acebutolol in the anaesthetised dog. Puddu, P.E., Jouve, R., Langlet, F., Guillen, J.C., Fornaris, M., Torresani, J., Reale, A. Cardiovasc. Res. (1986) [Pubmed]
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