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Chemical Compound Review

ZANTAC     (E)-N-[2-[[5- (dimethylaminomethyl)-2...

Synonyms: Alvidina, Azuranit, Ranibloc, Ranidura, Ranigast, ...
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Disease relevance of ranitidine


High impact information on ranitidine

  • Neurobiology. Trigger found for synapse formation [6].
  • The thermosome (Ths) chaperonin family represents the most salient PHX genes among Archaea. The chaperones Trigger factor and HSP70 have overlapping functions in the folding process, but both of these proteins are lacking in most archaea where they may be substituted by the chaperone prefoldin [7].
  • CONCLUSION: Trigger PSA, PSA velocity, and slope were associated with a positive BS [8].
  • Gangliosides Trigger Inflammatory Responses via TLR4 in Brain Glia [9].
  • Here we analyzed the potential of the Trigger Factor to shield nascent polypeptides at the ribosome [10].

Biological context of ranitidine


Anatomical context of ranitidine

  • The initially significant immune system activation was followed by a loss of the specific humoral immune response and a decrease in the cellular immune response to B burgdorferi over the course of the disease. "Trigger finger" developed, and a portion of the flexor retinaculum obtained at surgery was cultured [16].
  • Sitosterol-containing Lipoproteins Trigger Free Sterol-induced Caspase-independent Death in ACAT-competent Macrophages [17].
  • Finally, we found that in the absence of the ribosome-associated chaperone, trigger factor (Tig), LamB-LacZ localized to the periplasm in a SecA-dependent, SRP-independent fashion [18].
  • EGF-Induced Activation of the EGF Receptor Does Not Trigger Mobilization of Caveolae [19].

Gene context of ranitidine

  • PURPOSE: Ergonomic studies suggest that the commonly used pinch grasp, held in a static position, is a contributing factor for dental Hygienists' development of work-related musculoskeletal disorders (WMSDs) such as carpal tunnel syndrome (CTS), Trigger Thumb, de Quervain's stenosing tenosynovitis, and carpometacarpal (CMC) osteoarthritis [20].
  • Coherent averaging technique: a tutorial review. Part 2: Trigger jitter, overlapping responses and non-periodic stimulation [21].

Analytical, diagnostic and therapeutic context of ranitidine

  • The outcome of interest was postoperative blood transfusion. "Trigger hemoglobin" was the lowest hemoglobin recorded before transfusion or recorded at any time during the week before or after surgery for patients who were not transfused [22].
  • Unilateral cases of either type of epicondylitis (n = 283) were randomly allocated to one of three treatment groups according to the LLLT technique applied: (1) Trigger points; (2) Scanner; (3) Combination Treatment (i.e., TPs and scanner technique) [23].
  • The Trigger Tool technique was used to identify the rate of occurrence of adverse events in the intensive care unit (ICU), and a subset of ICUs described those events in detail [24].


  1. A role for trigger factor and an rgg-like regulator in the transcription, secretion and processing of the cysteine proteinase of Streptococcus pyogenes. Lyon, W.R., Gibson, C.M., Caparon, M.G. EMBO J. (1998) [Pubmed]
  2. The C-terminal Domain of Escherichia coli Trigger Factor Represents the Central Module of Its Chaperone Activity. Merz, F., Hoffmann, A., Rutkowska, A., Zachmann-Brand, B., Bukau, B., Deuerling, E. J. Biol. Chem. (2006) [Pubmed]
  3. How Proteins Trigger Excitation Energy Transfer in the FMO Complex of Green Sulfur Bacteria. Adolphs, J., Renger, T. Biophys. J. (2006) [Pubmed]
  4. Consequences of a single short lasting cerebral oligemia and the influence of iron injected into the substantia nigra or in the ventrolateral striatum of the rat. Trigger of Parkinson's disease pathogenesis? Heim, C., Sontag, T.A., Kolasiewicz, W., Ulrich, F., Pardowitz, I., Horn, H.J., Gerlach, M., Riederer, P., Sontag, K.H. Journal of neural transmission (Vienna, Austria : 1996) (2004) [Pubmed]
  5. Rheumatic Fever: How S. pyogenes-Primed Peripheral T Cells Trigger Heart Valve Lesions. Guilherme, L., Faé, K.C., Oshiro, S.E., Tanaka, A.C., Pomerantzeff, P.M., Kalil, J. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
  6. Neurobiology. Trigger found for synapse formation. Gura, T. Science (2000) [Pubmed]
  7. Predicted highly expressed genes in archaeal genomes. Karlin, S., Mrázek, J., Ma, J., Brocchieri, L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  8. Pattern of prostate-specific antigen (PSA) failure dictates the probability of a positive bone scan in patients with an increasing PSA after radical prostatectomy. Dotan, Z.A., Bianco, F.J., Rabbani, F., Eastham, J.A., Fearn, P., Scher, H.I., Kelly, K.W., Chen, H.N., Schöder, H., Hricak, H., Scardino, P.T., Kattan, M.W. J. Clin. Oncol. (2005) [Pubmed]
  9. Gangliosides Trigger Inflammatory Responses via TLR4 in Brain Glia. Jou, I., Lee, J.H., Park, S.Y., Yoon, H.J., Joe, E.H., Park, E.J. Am. J. Pathol. (2006) [Pubmed]
  10. Trigger factor forms a protective shield for nascent polypeptides at the ribosome. Hoffmann, A., Merz, F., Rutkowska, A., Zachmann-Brand, B., Deuerling, E., Bukau, B. J. Biol. Chem. (2006) [Pubmed]
  11. The Protein Kinase C{delta} Catalytic Fragment Targets Mcl-1 for Degradation to Trigger Apoptosis. Sitailo, L.A., Tibudan, S.S., Denning, M.F. J. Biol. Chem. (2006) [Pubmed]
  12. Further studies on opioids and hibernation: delta opioid receptor ligand selectively induced hibernation in summer-active ground squirrels. Oeltgen, P.R., Nilekani, S.P., Nuchols, P.A., Spurrier, W.A., Su, T.P. Life Sci. (1988) [Pubmed]
  13. Neurobehavioral syndrome induced by H2-receptor blocker withdrawal: possible role of prolactin. Rampello, L., Raffaele, R., Nicoletti, G., Le Pira, F., Vecchio, I., Malaguarnera, M., Drago, F. Clinical neuropharmacology. (1997) [Pubmed]
  14. Measurement of patient fears about implantable cardioverter defibrillator shock: an initial evaluation of the Florida Shock Anxiety Scale. Kuhl, E.A., Dixit, N.K., Walker, R.L., Conti, J.B., Sears, S.F. Pacing and clinical electrophysiology : PACE. (2006) [Pubmed]
  15. The genetic control of virulence in group A streptococci. II. Trigger effect by plasmids on anti-phagocytic activity, opacity factor and IgG and IgA Fc-receptors. Burova, L.A., Ravdonikas, L.E., Christensen, P., Schalén, C., Totolian, A.A. Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology. (1983) [Pubmed]
  16. Persistence of Borrelia burgdorferi in ligamentous tissue from a patient with chronic Lyme borreliosis. Häupl, T., Hahn, G., Rittig, M., Krause, A., Schoerner, C., Schönherr, U., Kalden, J.R., Burmester, G.R. Arthritis Rheum. (1993) [Pubmed]
  17. Sitosterol-containing Lipoproteins Trigger Free Sterol-induced Caspase-independent Death in ACAT-competent Macrophages. Bao, L., Li, Y., Deng, S.X., Landry, D., Tabas, I. J. Biol. Chem. (2006) [Pubmed]
  18. Secretion of LamB-LacZ by the signal recognition particle pathway of Escherichia coli. Bowers, C.W., Lau, F., Silhavy, T.J. J. Bacteriol. (2003) [Pubmed]
  19. EGF-Induced Activation of the EGF Receptor Does Not Trigger Mobilization of Caveolae. Kazazic, M., Roepstorff, K., Johannessen, L.E., Pedersen, N.M., van Deurs, B., Stang, E., Madshus, I.H. Traffic (2006) [Pubmed]
  20. Comparison of muscle activity associated with structural differences in dental hygiene mirrors. Simmer-Beck, M., Bray, K.K., Branson, B., Glaros, A., Weeks, J. Journal of dental hygiene : JDH / American Dental Hygienists' Association. (2006) [Pubmed]
  21. Coherent averaging technique: a tutorial review. Part 2: Trigger jitter, overlapping responses and non-periodic stimulation. Rompelman, O., Ros, H.H. Journal of biomedical engineering. (1986) [Pubmed]
  22. How you look determines what you find: severity of illness and variation in blood transfusion for hip fracture. Poses, R.M., Berlin, J.A., Noveck, H., Lawrence, V.A., Huber, E.C., O'Hara, D.A., Spence, R.K., Duff, A., Strom, B.L., Carson, J.L. Am. J. Med. (1998) [Pubmed]
  23. Treatment of medial and lateral epicondylitis--tennis and golfer's elbow--with low level laser therapy: a multicenter double blind, placebo-controlled clinical study on 324 patients. Simunovic, Z., Trobonjaca, T., Trobonjaca, Z. Journal of clinical laser medicine & surgery. (1998) [Pubmed]
  24. A trigger tool to identify adverse events in the intensive care unit. Resar, R.K., Rozich, J.D., Simmonds, T., Haraden, C.R. Joint Commission journal on quality and patient safety / Joint Commission Resources. (2006) [Pubmed]
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