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Chemical Compound Review

Metaprel     5-[1-hydroxy-2-(propan-2...

Synonyms: Alupent, Astmopent, Prometa, Alotec, ORCIPRENALINE, ...
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Disease relevance of ORCIPRENALINE


Psychiatry related information on ORCIPRENALINE


High impact information on ORCIPRENALINE


Chemical compound and disease context of ORCIPRENALINE


Biological context of ORCIPRENALINE

  • METHODS: In a prospective, randomized, double-blind, and placebo-controlled trial at a municipal hospital emergency department, 44 patients with acute asthma, aged 18 to 45 years, with theophylline levels below 28 mumol/L, who had failed to achieve a PEFR of 40% predicted after one nebulized metaproterenol treatment, were recruited [15].
  • On a 3 test days, 1, 43, and 85, mean peak responses for FEV1 and forced vital capacity and mean area under the curve were significantly higher for the iprathropium bromide-metaproterenol combination than for metaproterenol only [16].
  • Pulse rate increases occurring after metaproterenol were not considered clinically important [17].
  • Symptoms of wheezing, coughing, exercise intolerance, and interference with sleep were more frequently associated with the oral metaproterenol regimen; completely asymptomatic days occurred 50% more frequently in association with theophylline therapy (P less than 0.01) [18].
  • In the current study in humans, we examined the in vitro impact of a beta-adrenergic agonist, metaproterenol (MP), on NK activity, comparing blood drawn from (a) women tested at 3-4 different phases of their menstrual cycle (n = 10), (b) women using oral contraceptives (OC) (n = 10), and (c) men (n = 7) [19].

Anatomical context of ORCIPRENALINE


Associations of ORCIPRENALINE with other chemical compounds


Gene context of ORCIPRENALINE

  • The stimulatory effects of IGF-II were potentiated by UK-14304 (5-bromo-6-[2-imidazolin-2-ylamino]-quinoxaline) (10(-5) M) and inhibited by phenylephrine, PMA, metaproterenol, 8-bromo-cAMP, PD98059, rapamycin, and pertussis toxin [30].
  • To determine the effect of chronic catecholamine infusion in vivo, we measured apoptosis marker expression in C57Bl/6 and catecholamine-sensitive Egr-1 deficient mice after treatment with the nonspecific beta-adrenergic agonist, isoproterenol, the beta1-specific agonist, dobutamine, or the beta2-specific agonist, metaproterenol [31].
  • The typical effects of organ relaxation, inhibition of contraction height and reduction of resting tension generated by histamine, could both be antagonized by the histamine H2-receptor blockers metiamide and cimetidine, while both compounds failed to reverse orciprenaline- or isoproterenol-induced inhibition of uterine contractility [32].
  • These results suggest that the combination of iprathropium bromide and metaproterenol inhalation solutions offers a potential therapeutic advantage to patients with symptomatic COPD over nebulized metaproterenol alone without the risk of increased side effects [16].
  • The effects of deep inspiration upon expiratory flow rates and response to inhaled metaproterenol were studied in normal and asthmatic subjects using partial (PEFV) and maximal (MEFV) expiratory flow volume curves [33].

Analytical, diagnostic and therapeutic context of ORCIPRENALINE


  1. Long-term metaproterenol therapy in asthmatic children. Brandon, M.L. JAMA (1976) [Pubmed]
  2. Successful treatment of terbutaline-induced bronchospasm with orciprenaline sulfate. Drexel, H., Regele, M., Langle, U. Lancet (1982) [Pubmed]
  3. Aminophylline for acute exacerbations of chronic obstructive pulmonary disease. A controlled trial. Rice, K.L., Leatherman, J.W., Duane, P.G., Snyder, L.S., Harmon, K.R., Abel, J., Niewoehner, D.E. Ann. Intern. Med. (1987) [Pubmed]
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  5. Comparison of the anticholinergic bronchodilator ipratropium bromide with metaproterenol in chronic obstructive pulmonary disease. A 90-day multi-center study. Tashkin, D.P., Ashutosh, K., Bleecker, E.R., Britt, E.J., Cugell, D.W., Cummiskey, J.M., DeLorenzo, L., Gilman, M.J., Gross, G.N., Gross, N.J. Am. J. Med. (1986) [Pubmed]
  6. Interpretation of positive results of a methacholine inhalation challenge and 1 week of inhaled bronchodilator use in diagnosing and treating cough-variant asthma. Irwin, R.S., French, C.T., Smyrnios, N.A., Curley, F.J. Arch. Intern. Med. (1997) [Pubmed]
  7. Dietary adrenergic active compounds and the response of broilers to isoproterenol and cyclic adenosine monophosphate in vitro. Rosebrough, R.W. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (2001) [Pubmed]
  8. Corticosterone induction of cleft palate in mice dosed with orciprenaline sulfate. Iida, H., Kast, A., Tsunenari, Y., Asakura, M. Teratology (1988) [Pubmed]
  9. In vivo beta-adrenergic stimulation suppresses natural killer activity and compromises resistance to tumor metastasis in rats. Shakhar, G., Ben-Eliyahu, S. J. Immunol. (1998) [Pubmed]
  10. Characterization of the beta-adrenergic receptor of the rat peritoneal macrophage. Abrass, C.K., O'Connor, S.W., Scarpace, P.J., Abrass, I.B. J. Immunol. (1985) [Pubmed]
  11. Beta-adrenergic drugs in the management of asthma in athletes. Sly, R.M. J. Allergy Clin. Immunol. (1984) [Pubmed]
  12. The use of cromolyn in the management of hyperreactive airways and exercise. König, P. J. Allergy Clin. Immunol. (1984) [Pubmed]
  13. Metabolic and cardiovascular effects of carbuterol and metaproterenol. Sanders, J.P., Potter, D.E., Ellis, S., Bee, D.E., Grant, J.A. J. Allergy Clin. Immunol. (1977) [Pubmed]
  14. A randomized comparison of atropine and metaproterenol inhalational therapies for refractory status asthmaticus. Young, G.P., Freitas, P. Annals of emergency medicine. (1991) [Pubmed]
  15. Aminophylline in the treatment of acute asthma when beta 2-adrenergics and steroids are provided. Murphy, D.G., McDermott, M.F., Rydman, R.J., Sloan, E.P., Zalenski, R.J. Arch. Intern. Med. (1993) [Pubmed]
  16. Results of a multicenter study of nebulized inhalant bronchodilator solutions. Tashkin, D.P., Bleecker, E., Braun, S., Campbell, S., DeGraff, A.C., Hudgel, D.W., Boyars, M.C., Sahn, S. Am. J. Med. (1996) [Pubmed]
  17. Metaproterenol in children with chronic asthma. Hyde, J.S., Yamshon, D., Isenberg, P.D., Schur, S. Clin. Pharmacol. Ther. (1976) [Pubmed]
  18. Comparison of orally administered metaproterenol and theophylline in the control of chronic asthma. Dusdieker, L., Green, M., Smith, G.D., Ekwo, E.E., Weinberger, M. J. Pediatr. (1982) [Pubmed]
  19. Timing within the menstrual cycle, sex, and the use of oral contraceptives determine adrenergic suppression of NK cell activity. Shakhar, K., Shakhar, G., Rosenne, E., Ben-Eliyahu, S. Br. J. Cancer (2000) [Pubmed]
  20. Desensitization and resensitization of beta-adrenergic receptors in a smooth muscle cell line. Scarpace, P.J., Baresi, L.A., Sanford, D.A., Abrass, I.B. Mol. Pharmacol. (1985) [Pubmed]
  21. Concentration-response curves of positive inotropic agents before and after ouabain pretreatment. Brown, L., Erdmann, E. Cardiovasc. Res. (1985) [Pubmed]
  22. Metered dose inhaler aerosol characteristics are affected by the endotracheal tube actuator/adapter used. Bishop, M.J., Larson, R.P., Buschman, D.L. Anesthesiology (1990) [Pubmed]
  23. Dual effect of isoprenaline on glucose transport and response to insulin in isolated adipocytes. Joost, H.G., Göke, R., Steinfelder, H.J. Biochem. Pharmacol. (1985) [Pubmed]
  24. Effects of orciprenaline on the sinoatrial and atrioventricular nodes in presence of hypoxia. Senges, J., Hennig, E., Brachmann, J., Pelzer, D., Mizutani, T., Kübler, W. J. Mol. Cell. Cardiol. (1980) [Pubmed]
  25. Comparison of oral aminophylline and aerosol metaproterenol in asthma. Shim, C., Williams, M.H. Am. J. Med. (1981) [Pubmed]
  26. Bronchodilator effects of oral metaproterenol sulfate in preschool children with asthma. Nussbaum, E., Galant, S.P. J. Pediatr. (1987) [Pubmed]
  27. Mechanism of action of isoprenaline, isoxuprine, terbutaline and orciprenaline on gravid human isolated myometrium. Influence of the neuronal uptake process. Calixto, J.B., Simas, C.M. Biol. Reprod. (1984) [Pubmed]
  28. Catecholaminergic control of NK cell cytolytic activity regulatory factors in the spleen. Dokur, M., Boyadjieva, N., Sarkar, D.K. J. Neuroimmunol. (2004) [Pubmed]
  29. Effects of NO2 on chronic bronchitics. von Nieding, G., Wagner, H.M. Environ. Health Perspect. (1979) [Pubmed]
  30. Effects of insulin-like growth factor I and II on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes. Kimura, M., Ogihara, M. Eur. J. Pharmacol. (1998) [Pubmed]
  31. Chronic beta-adrenoreceptor stimulation in vivo decreased Bcl-2 and increased Bax expression but did not activate apoptotic pathways in mouse heart. Dostanic, S., Servant, N., Wang, C., Chalifour, L.E. Can. J. Physiol. Pharmacol. (2004) [Pubmed]
  32. Proestrus and metestrus rat uterus, a rapid and simple in vitro method for detecting histamine H2-receptor antagonism. Eltze, M. Arzneimittel-Forschung. (1979) [Pubmed]
  33. Partial and maximal expiratory flow-volume curves in normal and asthmatic subjects before and after inhalation of metaproterenol. Berry, R.B., Fairshter, R.D. Chest (1985) [Pubmed]
  34. Is electrical stimulation during administration of catecholamines required for the evaluation of success after ablation of atrioventricular node re-entrant tachycardias? Weismüller, P., Kuly, S., Brandts, B., Kattenbeck, K., Ranke, C., Trappe, H.J. J. Am. Coll. Cardiol. (2002) [Pubmed]
  35. Acute effects of aerosolized metaproterenol on breathing pattern of patients with symptomatic bronchial asthma. Tobin, M.J., Birch, S., Jenouri, G., Sackner, M.A. J. Allergy Clin. Immunol. (1985) [Pubmed]
  36. Effects of metaproterenol on pulmonary mechanics, oxygenation, and ventilation in infants with chronic lung disease. Cabal, L.A., Larrazabal, C., Ramanathan, R., Durand, M., Lewis, D., Siassi, B., Hodgman, J. J. Pediatr. (1987) [Pubmed]
  37. Aerosolized metaproterenol in the treatment of asthmatics with severe airflow obstruction. Comparison of two delivery methods. Salzman, G.A., Steele, M.T., Pribble, J.P., Elenbaas, R.M., Pyszczynski, D.R. Chest (1989) [Pubmed]
  38. Relative bioavailability of metaproterenol in humans utilizing a single dose, stable isotope approach. Hatch, F., McKellop, K., Hansen, G., MacGregor, T. Journal of pharmaceutical sciences. (1986) [Pubmed]
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