Chemical Compound Review:
Dithiol 4-methylbenzene-1,2-dithiol
Synonyms:
SureCN331198, NSC-5391, ACMC-1AHIT, AG-F-66236, ANW-30822, ...
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- Mechanisms of action of 2,3-dimercaptopropane-1-sulfonate and the transport, disposition, and toxicity of inorganic mercury in isolated perfused segments of rabbit proximal tubules. Zalups, R.K., Parks, L.D., Cannon, V.T., Barfuss, D.W. Mol. Pharmacol. (1998)
- Oxidation-reduction properties of disulfide-containing proteins of the Rhodobacter capsulatus cytochrome c biogenesis system. Setterdahl, A.T., Goldman, B.S., Hirasawa, M., Jacquot, P., Smith, A.J., Kranz, R.G., Knaff, D.B. Biochemistry (2000)
- Breaking and re-forming the disulfide bond at the high-potential, respiratory-type Rieske [2Fe-2S] center of thermus thermophilus: characterization of the sulfhydryl state by protein-film voltammetry. Zu, Y., Fee, J.A., Hirst, J. Biochemistry (2002)
- Redox regulation of cellular activation. Nakamura, H., Nakamura, K., Yodoi, J. Annu. Rev. Immunol. (1997)
- Twists in catalysis: alternating conformations of Escherichia coli thioredoxin reductase. Lennon, B.W., Williams, C.H., Ludwig, M.L. Science (2000)
- A genetic tool used to identify thioredoxin as a mediator of a growth inhibitory signal. Deiss, L.P., Kimchi, A. Science (1991)
- Complementation of DsbA deficiency with secreted thioredoxin variants reveals the crucial role of an efficient dithiol oxidant for catalyzed protein folding in the bacterial periplasm. Jonda, S., Huber-Wunderlich, M., Glockshuber, R., Mössner, E. EMBO J. (1999)
- Identification and characterization of a new disulfide isomerase-like protein (DsbD) in Escherichia coli. Missiakas, D., Schwager, F., Raina, S. EMBO J. (1995)
- Replacement of Trp28 in Escherichia coli thioredoxin by site-directed mutagenesis affects thermodynamic stability but not function. Slaby, I., Cerna, V., Jeng, M.F., Dyson, H.J., Holmgren, A. J. Biol. Chem. (1996)
- Thiol-mediated disassembly and reassembly of [2Fe-2S] clusters in the redox-regulated transcription factor SoxR. Ding, H., Demple, B. Biochemistry (1998)
- Evidence for a role of a vicinal dithiol in the transport of gamma-butyrobetaine in Agrobacterium sp. Nobile, S., Deshusses, J. Biochimie (1988)
- The primary structure of Escherichia coli glutaredoxin. Distant homology with thioredoxins in a superfamily of small proteins with a redox-active cystine disulfide/cysteine dithiol. Höög, J.O., Jörnvall, H., Holmgren, A., Carlquist, M., Persson, M. Eur. J. Biochem. (1983)
- Arsenical-based affinity chromatography of vicinal dithiol-containing proteins: purification of L1210 leukemia cytoplasmic proteins and the recombinant rat c-erb A beta 1 T3 receptor. Kalef, E., Walfish, P.G., Gitler, C. Anal. Biochem. (1993)
- Evidence for the involvement of coupling factor B in the H+ channel of the mitochondrial H+-ATPase. Sanadi, D.R., Pringle, M., Kantham, L., Hughes, J.B., Srivastava, A. Proc. Natl. Acad. Sci. U.S.A. (1984)
- Mitochondrial membrane sensitivity to depolarization in acute myeloblastic leukemia is associated with spontaneous in vitro apoptosis, wild-type TP53, and vicinal thiol/disulfide status. Pallis, M., Grundy, M., Turzanski, J., Kofler, R., Russell, N. Blood (2001)
- Molecular mapping of functionalities in the solution structure of reduced Grx4, a monothiol glutaredoxin from Escherichia coli. Fladvad, M., Bellanda, M., Fernandes, A.P., Mammi, S., Vlamis-Gardikas, A., Holmgren, A., Sunnerhagen, M. J. Biol. Chem. (2005)
- Identification and characterization of the second regulatory disulfide bridge of recombinant sorghum leaf NADP-malate dehydrogenase. Issakidis, E., Saarinen, M., Decottignies, P., Jacquot, J.P., Crétin, C., Gadal, P., Miginiac-Maslow, M. J. Biol. Chem. (1994)
- Vicinal dithiol-binding agent, phenylarsine oxide, inhibits inducible nitric-oxide synthase gene expression at a step of nuclear factor-kappaB DNA binding in hepatocytes. Oda, M., Sakitani, K., Kaibori, M., Inoue, T., Kamiyama, Y., Okumura, T. J. Biol. Chem. (2000)
- ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction. Tagaya, Y., Maeda, Y., Mitsui, A., Kondo, N., Matsui, H., Hamuro, J., Brown, N., Arai, K., Yokota, T., Wakasugi, H. EMBO J. (1989)
- Evidence for a dithiol-activated signaling pathway in natural killer cell avidity regulation of leukocyte function antigen-1: structural requirements and relationship to phorbol ester- and CD16-triggered pathways. Edwards, B.S., Curry, M.S., Southon, E.A., Chong, A.S., Graf, L.H. Blood (1995)
- Mechanism of action of the antifibrogenic compound gliotoxin in rat liver cells. Orr, J.G., Leel, V., Cameron, G.A., Marek, C.J., Haughton, E.L., Elrick, L.J., Trim, J.E., Hawksworth, G.M., Halestrap, A.P., Wright, M.C. Hepatology (2004)
- Singlet oxygen produced by photodynamic action causes inactivation of the mitochondrial permeability transition pore. Salet, C., Moreno, G., Ricchelli, F., Bernardi, P. J. Biol. Chem. (1997)
- DsbB elicits a red-shift of bound ubiquinone during the catalysis of DsbA oxidation. Inaba, K., Takahashi, Y.H., Fujieda, N., Kano, K., Miyoshi, H., Ito, K. J. Biol. Chem. (2004)
- Thioredoxin-catalyzed refolding of disulfide-containing proteins. Pigiet, V.P., Schuster, B.J. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant. Zhao, R., Masayasu, H., Holmgren, A. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Generating disulfides enzymatically: reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1p. Gross, E., Sevier, C.S., Heldman, N., Vitu, E., Bentzur, M., Kaiser, C.A., Thorpe, C., Fass, D. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence. Zhong, L., Arnér, E.S., Holmgren, A. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Glutathionylation of trypanosomal thiol redox proteins. Melchers, J., Dirdjaja, N., Ruppert, T., Krauth-Siegel, R.L. J. Biol. Chem. (2007)
- Acute cadmium exposure inactivates thioltransferase (Glutaredoxin), inhibits intracellular reduction of protein-glutathionyl-mixed disulfides, and initiates apoptosis. Chrestensen, C.A., Starke, D.W., Mieyal, J.J. J. Biol. Chem. (2000)
- A novel monothiol glutaredoxin (Grx4) from Escherichia coli can serve as a substrate for thioredoxin reductase. Fernandes, A.P., Fladvad, M., Berndt, C., Andrésen, C., Lillig, C.H., Neubauer, P., Sunnerhagen, M., Holmgren, A., Vlamis-Gardikas, A. J. Biol. Chem. (2005)
- Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms. Lundberg, M., Johansson, C., Chandra, J., Enoksson, M., Jacobsson, G., Ljung, J., Johansson, M., Holmgren, A. J. Biol. Chem. (2001)
- Thioredoxin-2 but not thioredoxin-1 is a substrate of thioredoxin peroxidase-1 from Drosophila melanogaster: isolation and characterization of a second thioredoxin in D. Melanogaster and evidence for distinct biological functions of Trx-1 and Trx-2. Bauer, H., Kanzok, S.M., Schirmer, R.H. J. Biol. Chem. (2002)
- Physiological functions of thioredoxin and thioredoxin reductase. Arnér, E.S., Holmgren, A. Eur. J. Biochem. (2000)
- Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity. Martin, B.R., Giepmans, B.N., Adams, S.R., Tsien, R.Y. Nat. Biotechnol. (2005)
- Iodophenylarsine oxide and arsenical affinity chromatography: new probes for dithiol proteins. Application to tubulins and to components of the insulin receptor-glucose transporter signal transduction pathway. Hoffman, R.D., Lane, M.D. J. Biol. Chem. (1992)
- Gliotoxin causes oxidative damage to plasmid and cellular DNA. Eichner, R.D., Waring, P., Geue, A.M., Braithwaite, A.W., Müllbacher, A. J. Biol. Chem. (1988)