Disease relevance of Hematoma, Subdural, Acute

• OBJECTIVE: To evaluate clinical outcomes and postoperative physiological findings for comatose patients with acute subdural hematomas who received preoperative high-dose mannitol (HDM) versus conventional-dose mannitol treatment [1].
• Simulation of acute subdural hematoma and diffuse axonal injury in coronal head impact [2].
• The new position furnished a direct line of sight to the apex of the IV ventricle corresponding to that provided by the classic high sitting position, without the latter's risks of air embolism and of acute subdural hematoma secondary to tearing of corticodural bridging vessels due to escape of gravity-impelled CSF from the large ventricles [3].
• We report 6 cases of acute subdural hematoma associated with cerebral infarction (SDH/CI) in term neonates, an entity which has not been well-documented previously [4].

High impact information on Hematoma, Subdural, Acute

• In the acute subdural hematoma model, repinotan (3 and 10 microg/kg per hour) reduced infarct volume by 65% [5].
• Tempol, a novel stable nitroxide, reduces brain damage and free radical production, after acute subdural hematoma in the rat [6].
• Reducing hemoglobin oxygen affinity does not increase hydroxyl radicals after acute subdural hematoma in the rat [7].
• The neuroprotective effect of the forebrain-selective NMDA antagonist CP101,606 upon focal ischemic brain damage caused by acute subdural hematoma in the rat [8].
• We report the effect of dextromethorphan, a commonly used antitussive and a noncompetitive NMDA-type glutamate receptor antagonist, on the volume of histologic damage seen at 72 h after acute subdural hematoma in the rat [9].

Chemical compound and disease context of Hematoma, Subdural, Acute

• Glucose hypermetabolism after acute subdural hematoma is ameliorated by a competitive NMDA antagonist [10].
• We have measured regional cerebral glucose metabolism (2-deoxyglucose autoradiography) in a new rat model of acute subdural hematoma and compared the changes to those seen in sham-operated control animals and animals pretreated with a high-affinity competitive NMDA antagonist, D-CPP-ene [10].
• Improving clinical outcomes from acute subdural hematomas with the emergency preoperative administration of high doses of mannitol: a randomized trial [1].
• The neuroprotective effect of a new serotonin receptor agonist, BAY X3702, upon focal ischemic brain damage caused by acute subdural hematoma in the rat [11].
• Abnormal CO2 vasoresponsivity was found with acute subdural hematomas and defuse cerebral swelling but not with epidural hematomas [12].

Biological context of Hematoma, Subdural, Acute

• Effect of neuroprotective N-methyl-D-aspartate antagonists on increased intracranial pressure: studies in the rat acute subdural hematoma model [13].

Gene context of Hematoma, Subdural, Acute

• We tested the neuroprotective effect of a novel, high affinity serotonin (5-HT1A) agonist, BAY X3702, in a rat model of acute subdural hematoma (ASDH) [11].
• BACKGROUND: Patients who have an acute subdural hematoma with a thickness of 10 mm or less and with a shift of the midline structures of 5 mm or less often can be treated nonoperatively [14].
• Treatment of acute subdural hematoma with a low GCS score [15].
• Follow-up CT scan of brain 2 hours after the initial one showed resolution and redistribution of the subdural hematoma.To our knowledge, this is the first case in the literature about spontaneous resolution of an acute subdural hematoma in a patient with a linear fracture and the fastest resolution period [16].

Analytical, diagnostic and therapeutic context of Hematoma, Subdural, Acute

• The patient was a fifty two years old man, mechanic valve recipient with Warfarin-induced coagulopathy: International Normalization Ratio (INR) of 6.39, who suffered from acute subdural hematoma and needed urgent neurosurgical intervention [17].

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