Disease relevance of Multicystic Dysplastic Kidney

• The finding of multicystic dysplastic kidney in renal coloboma syndrome could suggest that PAX2 may play a role in early ureteric obstruction and subsequent renal maldevelopment [1].
• Two patients had the complication of hypertension before removal of the multicystic dysplastic kidney but plasma renin activity was normal [2].
• In previous studies, we described a fetus carrying a t(6;19)(p21;q13.1) as the sole cytogenetic anomaly and suffering from bilateral multicystic renal dysplasia caused by a bilateral complete pelviureteric junction obstruction, resulting in a massive hydronephrosis [3].
• Joubert syndrome associated with Leber amaurosis and multicystic kidneys [4].
• Joubert syndrome associated with multicystic kidney disease and hepatic fibrosis [5].

High impact information on Multicystic Dysplastic Kidney

• A mother with VCFS and unilateral dysplastic kidney and her fetus with multicystic dysplastic kidneys: additional evidence to support the association of renal malformations and VCFS [6].
• To evaluate multicystic dysplastic kidney (MDK) and associated contralateral renal abnormalities in the fetal population, 27 cases detected and followed in utero were reviewed retrospectively [7].
• MATERIALS AND METHODS: We comprehensively reviewed the published literature linking hypertension with urinary tract infection, renal scarring, vesicoureteral reflux, multicystic dysplastic kidney, ureteropelvic junction obstruction and posterior urethral valves [8].
• Reduced renin expression and altered gene transcript profiles in multicystic dysplastic kidneys [9].
• Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a patient with multicystic renal dysplasia [3].

Chemical compound and disease context of Multicystic Dysplastic Kidney

• In an attempt to determine whether a relationship exists between renal dysplasia and neoplasia in terms of abnormalities of cellular deoxyribonucleic acid content we performed flow cytometric evaluation on 30 formalin fixed, paraffin embedded archival specimens of multicystic dysplastic kidneys [10].
• The value of 99mTechnetium-mercapto acetyl triglycine (99mTcMAG3) in the investigation of 10 children with suspected multicystic dysplastic kidney (MCDK) has been assessed [11].
• The change of the pattern of clinical presentation of primary hyperparathyroidism in older patients is illustrated by a case history of a 61-year-old woman with multicystic kidney disease in whom a thiazide antihypertensive drug (clopamide) induced a very severe symptomatic hypercalcemia [12].

Biological context of Multicystic Dysplastic Kidney

• Structure, sequence, and chromosome 19 localization of human USF2 and its rearrangement in a patient with multicystic renal dysplasia [13].
• The autosomal recessive polycystic kidney disease (ARPK), autosomal dominant polycystic kidney disease (ADPK), multicystic renal dysplasia, obstructive multicystic kidneys and cystic renal malformations found in other syndromes with genetic linkage are discussed in this review [14].

Anatomical context of Multicystic Dysplastic Kidney

• Other findings included hydrocephalus, craniofacial anomalies, thymic agenesis, supracristal ventricular septal defect, single umbilical artery, anal and vaginal atresia, and urethral agenesis with dysplastic, multicystic kidneys [15].

Gene context of Multicystic Dysplastic Kidney

• Finally, examination of a human multicystic dysplastic kidney demonstrated that malformed, hyperproliferative tubules expressed MET, whereas HGF/SF protein was immunolocalized to the same epithelia and also to the surrounding undifferentiated cells [16].
• Ten children (15%) with a multicystic kidney had contralateral vesicoureteral reflux, including 8 of 37 boys (22%) and 2 of 28 girls (7%) [17].
• MATERIALS AND METHODS: Immunohistochemical examination of renin was performed in 29 multicystic dysplastic kidneys from 14 boys and 15 girls 1 month to 10 years old using rabbit anti-human renin antibodies [2].
• Wilms tumor in a prenatally diagnosed multicystic kidney [18].
• MATERIALS AND METHODS: Two well documented cases of malignancy associated with multicystic dysplastic kidney disease are presented in 2 female infants (5 and 3 months old) [19].

Analytical, diagnostic and therapeutic context of Multicystic Dysplastic Kidney

• Antenatal diagnosis of Multicystic Renal Dysplasia [20].

References