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Gene Review

MAG  -  malignancy-associated protein

Homo sapiens

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Disease relevance of MAG


High impact information on MAG


Chemical compound and disease context of MAG


Biological context of MAG


Anatomical context of MAG


Associations of MAG with chemical compounds

  • MAG is a Schwann cell-based glycoprotein and has been implicated as a mediator of an outside-in signaling cascade influencing the cytoskeletal integrity of axons [2].
  • Synthesis of Neu5Ac oligosaccharides and analogues by transglycosylation and their binding properties as ligands to MAG [19].
  • Our aim was to study the relation between serum 1,25-dihydroxyvitamin D and humoral activity in malignancy-associated hypercalcaemia [20].
  • The mechanism for glucose hypermetabolic activity of PXA is not clear; however, the positive findings obtained from FDG-PET may not always indicate the degree of malignancy associated with PXA [21].
  • Efficacy of aminohydroxypropylidene diphosphonate in the treatment of malignancy-associated hypercalcaemia [22].

Regulatory relationships of MAG


Other interactions of MAG


Analytical, diagnostic and therapeutic context of MAG

  • By RT-PCR, MAG expression was not found in 12 different normal tissues but found in 46 of 51 (90%) premalignant and malignant tissues of various sites [1].
  • The expression of MAG was characterized using reverse transcription-PCR (RT-PCR), rapid amplification of cDNA ends PCR, RNA dot blotting, RNase protection assay, and Northern blot analysis [1].
  • One group of these rats (n = 14 sham, n = 11 injured) was killed at 72 h post-injury for verification of drug diffusion and MAG immunohistochemistry [17].
  • A retrospective study of patients with ARM and associated urogenital abnormalities admitted in the department of paediatric surgery of Sylhet MAG Osmani Medical College Hospital between 1998 and 2002 was undertaken [29].
  • Three allografts were subsequently lost in the MAG group [30].


  1. Novel human malignancy-associated gene (MAG) expressed in various tumors and in some tumor preexisting conditions. Ljubimova, J.Y., Wilson, S.E., Petrovic, L.M., Ehrenman, K., Ljubimov, A.V., Demetriou, A.A., Geller, S.A., Black, K.L. Cancer Res. (1998) [Pubmed]
  2. Anti-myelin-associated glycoprotein neuropathy. Steck, A.J., Stalder, A.K., Renaud, S. Curr. Opin. Neurol. (2006) [Pubmed]
  3. Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro. Horiuchi, N., Caulfield, M.P., Fisher, J.E., Goldman, M.E., McKee, R.L., Reagan, J.E., Levy, J.J., Nutt, R.F., Rodan, S.B., Schofield, T.L. Science (1987) [Pubmed]
  4. Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone. Strewler, G.J., Stern, P.H., Jacobs, J.W., Eveloff, J., Klein, R.F., Leung, S.C., Rosenblatt, M., Nissenson, R.A. J. Clin. Invest. (1987) [Pubmed]
  5. Imbalance of plasminogen activators and their inhibitors in human colorectal neoplasia. Implications of urokinase in colorectal carcinogenesis. Sier, C.F., Verspaget, H.W., Griffioen, G., Verheijen, J.H., Quax, P.H., Dooijewaard, G., De Bruin, P.A., Lamers, C.B. Gastroenterology (1991) [Pubmed]
  6. Comparative evaluation of carcinoembryonic antigen, secretory component, and mucins in index and metachronous adenomas of the colorectum. Griffioen, G., Bosman, F.T., Verspaget, H.W., Sier, K.F., Biemond, I., Lamers, C.B. Gastroenterology (1991) [Pubmed]
  7. The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis. Dobson, C.L., Warren, A.J., Pannell, R., Forster, A., Lavenir, I., Corral, J., Smith, A.J., Rabbitts, T.H. EMBO J. (1999) [Pubmed]
  8. Polyneuropathy attributes: a comparison between patients with anti-MAG and anti-sulfatide antibodies. Erb, S., Ferracin, F., Fuhr, P., Rösler, K.M., Hess, C.W., Kuntzer, T., Bogousslavsky, J., Sztajzel, R., Steck, A.J. J. Neurol. (2000) [Pubmed]
  9. A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis. Goldman, S.C., Holcenberg, J.S., Finklestein, J.Z., Hutchinson, R., Kreissman, S., Johnson, F.L., Tou, C., Harvey, E., Morris, E., Cairo, M.S. Blood (2001) [Pubmed]
  10. Treatment of malignancy-associated hypercalcemia with intravenous aminohydroxypropylidene diphosphonate. Body, J.J., Borkowski, A., Cleeren, A., Bijvoet, O.L. J. Clin. Oncol. (1986) [Pubmed]
  11. Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. Burtis, W.J., Wu, T., Bunch, C., Wysolmerski, J.J., Insogna, K.L., Weir, E.C., Broadus, A.E., Stewart, A.F. J. Biol. Chem. (1987) [Pubmed]
  12. Clodronate. A randomized study in the treatment of cancer-related hypercalcemia. Witte, R.S., Koeller, J., Davis, T.E., Benson, A.B., Durie, B.G., Lipton, A., Stock, J.L., Citrin, D.L., Jacobs, T.P. Arch. Intern. Med. (1987) [Pubmed]
  13. Myelin-associated glycoprotein-mediated signaling in central nervous system pathophysiology. Chen, Y., Aulia, S., Tang, B.L. Mol. Neurobiol. (2006) [Pubmed]
  14. Notch signaling in gastrointestinal tract (Review). Katoh, M., Katoh, M. Int. J. Oncol. (2007) [Pubmed]
  15. A synthetic peptide defines a serologic IgA response to a human papillomavirus-encoded nuclear antigen expressed in virus-carrying cervical neoplasia. Dillner, J., Dillner, L., Robb, J., Willems, J., Jones, I., Lancaster, W., Smith, R., Lerner, R. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  16. Acquired immunodeficiency syndrome: epidemiology, virology, and immunology. Weiss, A., Hollander, H., Stobo, J. Annu. Rev. Med. (1985) [Pubmed]
  17. Tissue sparing and functional recovery following experimental traumatic brain injury is provided by treatment with an anti-myelin-associated glycoprotein antibody. Thompson, H.J., Marklund, N., Lebold, D.G., Morales, D.M., Keck, C.A., Vinson, M., Royo, N.C., Grundy, R., McIntosh, T.K. Eur. J. Neurosci. (2006) [Pubmed]
  18. Passive immunization with anti-ganglioside antibodies directly inhibits axon regeneration in an animal model. Lehmann, H.C., Lopez, P.H., Zhang, G., Ngyuen, T., Zhang, J., Kieseier, B.C., Mori, S., Sheikh, K.A. J. Neurosci. (2007) [Pubmed]
  19. Synthesis of Neu5Ac oligosaccharides and analogues by transglycosylation and their binding properties as ligands to MAG. Neubacher, B., Scheid, S., Kelm, S., Frasch, A.C., Meyer, B., Thiem, J. Chembiochem (2006) [Pubmed]
  20. Malignancy-associated hypercalcaemia: resolution of controversies over vitamin D metabolism by a pathophysiological approach to the syndrome. Schweitzer, D.H., Hamdy, N.A., Frölich, M., Zwinderman, A.H., Papapoulos, S.E. Clin. Endocrinol. (Oxf) (1994) [Pubmed]
  21. Evaluation of pleomorphic xanthoastrocytoma by use of positron emission tomography with. Tsuyuguchi, N., Matsuoka, Y., Sunada, I., Matsusaka, Y., Haque, M. AJNR. American journal of neuroradiology. (2001) [Pubmed]
  22. Efficacy of aminohydroxypropylidene diphosphonate in the treatment of malignancy-associated hypercalcaemia. Stevens, M.J. Med. J. Aust. (1987) [Pubmed]
  23. Design and applications of parathyroid hormone analogues. Morley, P., Whitfield, J.F., Willick, G.E. Current medicinal chemistry. (1999) [Pubmed]
  24. A practical approach to hypercalcemia. Carroll, M.F., Schade, D.S. American family physician. (2003) [Pubmed]
  25. Effects of treatment of malignancy-associated hypercalcemia on serum parathyroid hormone-related protein. Budayr, A.A., Zysset, E., Jenzer, A., Thiébaud, D., Ammann, P., Rizzoli, R., Jaquet-Müller, F., Bonjour, J.P., Gertz, B., Burckhardt, P. J. Bone Miner. Res. (1994) [Pubmed]
  26. Surveillance for Early Detection of Aggressive Parathyroid Disease: Carcinoma and Atypical Adenoma in Familial Isolated Hyperparathyroidism Associated With a Germline HRPT2 Mutation. Kelly, T.G., Shattuck, T.M., Reyes-Mugica, M., Stewart, A.F., Simonds, W.F., Udelsman, R., Arnold, A., Carpenter, T.O. J. Bone Miner. Res. (2006) [Pubmed]
  27. p53 and FHIT mutations and microsatellite alterations in malignancy-associated pleural effusion. Lee, J.H., Hong, Y.S., Ryu, J.S., Chang, J.H. Lung Cancer (2004) [Pubmed]
  28. The epithelial-specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression. Eckel, K.L., Tentler, J.J., Cappetta, G.J., Diamond, S.E., Gutierrez-Hartmann, A. DNA Cell Biol. (2003) [Pubmed]
  29. Urogenital anomalies associated with anorectal malformations in children. Alam, M.S., Chowdhury, M.K., Islam, M.K. Mymensingh medical journal : MMJ. (2006) [Pubmed]
  30. Comparison of Minnesota antilymphocyte globulin and OKT3 for induction of immunosuppression in renal transplant patients. Light, J.A., Khawand, N., Ali, A., Brems, W., Aquino, A. Transplant. Proc. (1989) [Pubmed]
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