Disease relevance of PUJO

• The association of pelvi-ureteric junction obstruction (PUJO) and rapidly fatal persistent pulmonary hypertension of the newborn (PPHN) has been observed in two male siblings [1].
• PUJO was also observed in a maternal uncle, whose daughter suffered from vesico-ureteral reflux (VUR) [1].
• OBJECTIVE: To determine the incidence and efficacy of treatment for pelvi-ureteric junction obstruction (PUJO, the most common cause of hydronephrosis in the fetal kidney) in duplicated systems [2].
• PATIENTS AND METHODS: From November 2002 to April 2005, 55 patients had RALP for PUJO; eight of these had concomitant renal calculi [3].
• This late presentation of lower moiety PUJO with pyonephrosis has not been described previously [4].

High impact information on PUJO

• In previous studies, we described a fetus carrying a t(6;19)(p21;q13.1) as the sole cytogenetic anomaly and suffering from bilateral multicystic renal dysplasia caused by a bilateral complete pelviureteric junction obstruction, resulting in a massive hydronephrosis [5].
• Pelviureteric junction obstruction and recurrent abdominal pain in childhood [6].
• There seems no doubt that VUR is linked to HLA whilst the case for PUJO is equivocal [7].
• Our experience indicates how the diuresis renogram not only gives functional confirmation of a pelviureteric junction obstruction, but is also helpful in resolving situations in which there is a discrepancy between symptoms and urographic signs [8].
• The authors report an unusual case of a baby boy presenting with bilateral emphysematous pyelonephritis and cystitis associated with bilateral pelviureteric junction obstruction and urinary tract infection [9].

Biological context of PUJO

• The inheritance of HLA haplotypes has been looked at in a family with pelvi-ureteric junction obstruction (PUJO) and two families with vesicoureteric reflux (VUR) [7].
• Between 1989 and 1990, 31 new unilateral PUJO, prenatally diagnosed (16th-37th week of gestational age), underwent pyeloplasty between 19 and 105 days of age [10].
• We believe that this technique is more useful than standard urodynamic tests and is of particular value in patients with equivocal pelviureteric junction obstruction and in those who have undergone previous surgery [11].
• A prospective therapeutic strategy based on separate glomerular filtration rate (SGFR) was evaluated in 14 prenatally detected asymptomatic neonates, suspected of having pelviureteric junction obstruction [12].

Anatomical context of PUJO

• In conclusion, in PUJO, the shorter the delta t and the lower the V, the better one expects the smooth musculature of the upper urinary tract to be [13].
• Pelviureteric junction obstruction: how much is the extent of the upper ureter with defective innervation needing resection [14]?
• Follow-up of 339 renal units (333 patients), for a minimum of 60 months, revealed minor late sequelae such as pelviureteric junction obstruction in 1 patient (0.3%) and post-catheterisation strictures of the anterior urethra in 4 (1.2%) [15].
• To study the surgical treatment and outcome of hydronephrosis secondary to pelviureteric junction obstruction (PUJS) that is so massive that the renal pelvis crosses over the vertebral column [mega-hydronephrosis (MH)] [16].

Associations of PUJO with chemical compounds

• It was thought that this method may be of use in the diagnosis and follow-up of pelviureteric junction obstruction, and that its sensitivity may be increased by the use of intravenous furosemide to raise the intrarenal pressure in obstructive cases [17].
• Eighty-one 99mTc DTPA renograms were performed in 31 children who had previously undergone pyeloplasty for pelviureteric junction obstruction (PUJ) [18].

Other interactions of PUJO

• CONCLUSIONS: TGF-beta1 expression was increased and EGF expression was decreased in the renal tissue after clinical PUJO [19].
• OBJECTIVES: To study the potential role of pelviureteral junction obstruction (PUJO) in causing progressive renal damage in children through the renal expression of epidermal growth factor (EGF) and transforming growth factor-beta1 (TGF-beta1) [19].
• Pelviureteric junction obstruction secondary to renal pelvic incarceration in a congenital diaphragmatic hernia [20].

Analytical, diagnostic and therapeutic context of PUJO

• OBJECTIVE: To analyse the long-term success of retrograde balloon dilatation (RBD) of pelvi-ureteric junction obstruction (PUJO) [21].
• OBJECTIVE: To evaluate the role of multiphasic helical computed tomography (CT) in planning surgical treatment for pelvi-ureteric junction obstruction (PUJO) [22].
• A retrospective study was carried out by evaluation of the records of patients who underwent A-H pyeloplasty for unilateral PUJO and reported for a follow up renal dynamic scan between the years 2000 and 2003 [23].
• Standard intravenous pyelography showed an increase in pelvis size compatible with PUO in 2 patients from group 2 and in all patients from group 3.(ABSTRACT TRUNCATED AT 250 WORDS)[24]
• Re: Low grade pelviureteric junction obstruction with normal diuretic renography [25].

References