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Disease relevance of Crotalaria


High impact information on Crotalaria

  • An outbreak of veno-occlusive disease which was probably caused by consumption of cereals mixed with seeds of a plant (Crotalaria sp.) containing pyrrolizidine alkaloids occurred in the Sarguja district of India in November-December 1975 [2].
  • It was found that wheat germ agglutinin and a lectin from Crotalaria juncea were effective inhibitors and that their inhibitory effects could be neutralized by N-acetylglucosamine and galactose, respectively, suggesting that the receptor contains these sugars [3].
  • An African youth who had died from primary pulmonary hypertension was suspected of having ingested a herbal remedy containing the seeds of the local plant Crotalaria laburnoides [4].
  • A prenylated chalcone 2 named crotaorixin, has been isolated from the aerial parts of the Crotalaria orixensis [5].
  • Recruitment of alkaloid-specific homospermidine synthase (HSS) from ubiquitous deoxyhypusine synthase: Does Crotalaria possess a functional HSS that still has DHS activity [6]?

Biological context of Crotalaria

  • The Crotalaria group during exercise had increased PAP, RVWI, TPVRI, and total systemic vascular resistance index and decreased BP, O2 consumption, CaO2, CvO2, CI, SVI, LVWI, O2 pulse index, and exercise duration [7].
  • The moth Utetheisa ornatrix derives protection against predation from systemic pyrrolizidine alkaloids (PAs) that it sequesters as a larva from its foodplants (Leguminosae, Crotalaria spp.). We here show, in laboratory tests, that Utetheisa deficient in body PA can make up for the chemical shortfall by cannibalizing pupae [8].

Anatomical context of Crotalaria


Associations of Crotalaria with chemical compounds

  • A polysaccharide isolated from the seeds of Crotalaria medicaginea is composed of D-galactose and D-mannose in the molar ratio of 10:31 [10].
  • A galactomannan from Crotalaria medicaginea seeds [10].
  • Residues of aflatoxin B1 and aflatoxin M1 were found in the kidneys of poults fed aflatoxin B1; also, dehydroretronecine (the metabolite of monocrotaline) was detected in livers of poults fed Crotalaria spectabilis seeds [11].
  • One new isoflavone, 5,7,4'-trihydroxy-2'-methoxyisoflavone (3) and seven, and four known compounds were isolated from the barks of Crotalaria pallida and the seeds of C. assamica, respectively [12].
  • Low values in TP, A, alpha G, and beta G and in body and liver weights were observed in groups given the combination of aflatoxin plus crotalaria [11].

Gene context of Crotalaria

  • Dry Crotalaria saltiana shoots were fed to strain ASL mice at 50, 10 and 1% of the diet [13].
  • Eighty three leguminous species including crop plants, weeds and trees have been screened for their content of leaf protein as well as extractabilities of leaf protein, total N and protein N. Leaves of Crotalaria sericea Retz. showed the highest values for extractabilities of LP and protein N as well as total N content in leaf protein [14].

Analytical, diagnostic and therapeutic context of Crotalaria


  1. Augmented adrenomedullin concentrations in right ventricle and plasma of experimental pulmonary hypertension. Shimokubo, T., Sakata, J., Kitamura, K., Kangawa, K., Matsuo, H., Eto, T. Life Sci. (1995) [Pubmed]
  2. An epidemic of veno-occlusive disease of liver in central India. Tandon, B.N., Tandon, H.D., Tandon, R.K., Narndranathan, M., Joshi, Y.K. Lancet (1976) [Pubmed]
  3. Characterization of the receptor for platelet-derived growth factor on human fibroblasts. Demonstration of an intimate relationship with a 185,000-Dalton substrate for the platelet-derived growth factor-stimulated kinase. Heldin, C.H., Ek, B., Rönnstrand, L. J. Biol. Chem. (1983) [Pubmed]
  4. A pulmonary hypertension-producing plant from Tanzania. Heath, D., Shaba, J., Williams, A., Smith, P., Kombe, A. Thorax (1975) [Pubmed]
  5. Prenylated chalcones isolated from Crotalaria genus inhibits in vitro growth of the human malaria parasite Plasmodium falciparum. Narender, T., Shweta, n.u.l.l., Tanvir, K., Rao, M.S., Srivastava, K., Puri, S.K. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  6. Recruitment of alkaloid-specific homospermidine synthase (HSS) from ubiquitous deoxyhypusine synthase: Does Crotalaria possess a functional HSS that still has DHS activity? Nurhayati, N., Ober, D. Phytochemistry (2005) [Pubmed]
  7. Hemodynamic and metabolic effects of exercise in Crotalaria-induced pulmonary hypertension in rats. McNabb, L.J., Baldwin, K.M. Journal of applied physiology: respiratory, environmental and exercise physiology. (1984) [Pubmed]
  8. Chemical basis of pupal cannibalism in a caterpillar (Utetheisa ornatrix). Bogner, F., Eisner, T. Experientia (1992) [Pubmed]
  9. Clastogenic effect of extracts obtained from Crotalaria retusa L. and Crotalaria mucronata Desv. on mouse bone marrow cells. Ribeiro, L.R., Silva, A.R., Bautista, A.R., Costa, S.L., Sales, L.A., Rios, A.C., Salvadori, D.M. Mutat. Res. (1993) [Pubmed]
  10. A galactomannan from Crotalaria medicaginea seeds. Gupta, A.K., BeMiller, J.N. Phytochemistry (1990) [Pubmed]
  11. Influence of selenium on aflatoxin B1 or crotalaria toxicity in turkey poults. Burguera, J.A., Edds, G.T., Osuna, O. Am. J. Vet. Res. (1983) [Pubmed]
  12. Anti-inflammatory flavonoids and pterocarpanoid from Crotalaria pallida and C. assamica. Ko, H.H., Weng, J.R., Tsao, L.T., Yen, M.H., Wang, J.P., Lin, C.N. Bioorg. Med. Chem. Lett. (2004) [Pubmed]
  13. Toxic effects of Crotalaria saltiana in mice. Barri, M.E., Adam, S.E., Omer, O.H. Veterinary and human toxicology. (1988) [Pubmed]
  14. Leaf protein content and yield of some Indian legumes. Pandey, V.N. Plant foods for human nutrition (Dordrecht, Netherlands) (1994) [Pubmed]
  15. A phytohemagglutinin from Sunn hemp seeds (Crotalaria juncea). II. Purification by a high capacity biospecific affinity adsorbent and its physicochemical properties. Ersson, B. Biochim. Biophys. Acta (1977) [Pubmed]
  16. Determination of terminal sugars in transferrin by radio-lectin immunoassay (RLIA)-a new microanalytical procedure. Cervén, C., Stibler, H., Borg, S. Ups. J. Med. Sci. (1981) [Pubmed]
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