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Chemical Compound Review

AC1L3XCG     (2,5-dioxopyrrolidin-1-yl) 3-(4-hydroxy-3...

Synonyms: 65114-37-6
 
 
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Disease relevance of Bolton-Hunter reagent

 

High impact information on Bolton-Hunter reagent

  • Acylated ubiquitin could not be radiolabeled with a membrane-impermeable Bolton-Hunter reagent unless virus was pretreated with detergent [5].
  • Purified human IL-1 was labeled to high specific activity with 125I, using Bolton-Hunter reagent [6].
  • CSVTCG derivatized with [125I] Bolton-Hunter reagent was taken up by cells in a dose-dependent manner and the cell association was inhibited with a monospecific polyclonal anti-CBP antibody [7].
  • Highly purified eIF-2 from rabbit reticulocytes was labeled with 125I by using the Bolton-Hunter reagent or with [gamma-32P]ATP by using the heme-regulated translational inhibitor protein kinase [8].
  • Unlike the case with the chloramine T method, incorporation of a single mole of Bolton-Hunter reagent into a mole of IFN-beta Ser17 led to nearly complete loss of biological activity [9].
 

Biological context of Bolton-Hunter reagent

  • A conjugate (125I-BH-SP) between substance P and 125I-labeled Bolton-Hunter reagent binds reversibly to a single class of high affinity (Kd = 4 nM) binding sites on dispersed rat parotid cells [10].
  • A human lung tumor-associated antigen, previously purified to apparent homogeneity from an extract of a small cell tumor, was radioiodinated with Bolton-Hunter reagent for use in a competitive protein-binding radioimmunoassay [11].
  • Experiments designed (1) to detect structures at the 5' ends of phosphatase-treated nascent DNA molecules that caused them to be resistant to hydrolysis by spleen exonuclease or (2) to detect polypeptides that were associated covalently with small DNA molecules and could be iodinated with the Bolton-Hunter reagent did not yield positive results [12].
  • A radiolabeled analogue of neuromedin N has been prepared by acylation of the N-terminal amino group of the peptide with the 125I-labeled Bolton-Hunter reagent [13].
  • 1-Acyl-2-[[[3-(3-[125I]iodo-4-hydroxyphenyl)- propionyl]amino]caproyl]phosphatidylcholine (125I-PC) was prepared by alkylation of 1-acyl-2-(aminocaproyl)phosphatidylcholine with monoiodinated Bolton-Hunter reagent [14].
 

Anatomical context of Bolton-Hunter reagent

 

Associations of Bolton-Hunter reagent with other chemical compounds

 

Gene context of Bolton-Hunter reagent

 

Analytical, diagnostic and therapeutic context of Bolton-Hunter reagent

References

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  4. Characterization of relaxin radioimmunoassay using Bolton-Hunter reagent. First results in plasma during pregnancy, and in placenta, corpora lutea and ovarian cysts in woman. Loumaye, E., Teuwissen, B., Thomas, K. Gynecol. Obstet. Invest. (1978) [Pubmed]
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  23. Binding of a Bolton-Hunter substituted homostatine analog to affinity-immobilized human renin. Evenou, J.P., Weidmann, B., Hagenbach, A., Metternich, R., Pfenninger, E., Wagner, H. Biochem. Pharmacol. (1990) [Pubmed]
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  27. Radioiodination of transforming growth factor-beta (TGF-beta) in a modified Bolton-Hunter reaction system. Ross, J., Janero, D.R., Hreniuk, D., Wennogle, L.P. J. Biochem. Biophys. Methods (1993) [Pubmed]
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