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Chemical Compound Review

Delphinidin     2-(3,4,5- trihydroxyphenyl)chromene- 3,5,7...

Synonyms: CHEMBL276780, CHEBI:28436, AC1L2UKE, LS-69059, LMPK12010001, ...
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Disease relevance of Ephdine


High impact information on Ephdine


Chemical compound and disease context of Ephdine

  • Overall, these results demonstrate that Dp, Pt, and Cy affect plasminogen activation, thus leading to the inhibition of glioblastoma cell migration and therefore they may be helpful for the development of new strategies for cancer prevention and therapy [2].

Biological context of Ephdine


Anatomical context of Ephdine


Associations of Ephdine with other chemical compounds


Gene context of Ephdine


Analytical, diagnostic and therapeutic context of Ephdine


  1. Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines. Lazzè, M.C., Savio, M., Pizzala, R., Cazzalini, O., Perucca, P., Scovassi, A.I., Stivala, L.A., Bianchi, L. Carcinogenesis (2004) [Pubmed]
  2. Anthocyanidins inhibit migration of glioblastoma cells: Structure-activity relationship and involvement of the plasminolytic system. Lamy, S., Lafleur, R., B??dard, V., Moghrabi, A., Barrette, S., Gingras, D., B??liveau, R. J. Cell. Biochem. (2007) [Pubmed]
  3. Inhibitory effect of delphinidin from Solanum melongena on human fibrosarcoma HT-1080 invasiveness in vitro. Nagase, H., Sasaki, K., Kito, H., Haga, A., Sato, T. Planta Med. (1998) [Pubmed]
  4. Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and vegetables. Zhang, Y., Vareed, S.K., Nair, M.G. Life Sci. (2005) [Pubmed]
  5. Effects of the natural flavonoid delphinidin on diabetic microangiopathy. Bertuglia, S., Malandrino, S., Colantuoni, A. Arzneimittel-Forschung. (1995) [Pubmed]
  6. Absorption and metabolism of delphinidin 3-O-beta-D-glucopyranoside in rats. Ichiyanagi, T., Rahman, M.M., Kashiwada, Y., Ikeshiro, Y., Shida, Y., Hatano, Y., Matsumoto, H., Hirayama, M., Tsuda, T., Konishi, T. Free Radic. Biol. Med. (2004) [Pubmed]
  7. Biochemical and molecular characterization of a novel UDP-glucose:anthocyanin 3'-O-glucosyltransferase, a key enzyme for blue anthocyanin biosynthesis, from gentian. Fukuchi-Mizutani, M., Okuhara, H., Fukui, Y., Nakao, M., Katsumoto, Y., Yonekura-Sakakibara, K., Kusumi, T., Hase, T., Tanaka, Y. Plant Physiol. (2003) [Pubmed]
  8. Involvement of cyclin-dependent pathway in the inhibitory effect of delphinidin on angiogenesis. Favot, L., Martin, S., Keravis, T., Andriantsitohaina, R., Lugnier, C. Cardiovasc. Res. (2003) [Pubmed]
  9. Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved. Hou, D.X., Yanagita, T., Uto, T., Masuzaki, S., Fujii, M. Biochem. Pharmacol. (2005) [Pubmed]
  10. Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis. Martin, S., Giannone, G., Andriantsitohaina, R., Martinez, M.C. Br. J. Pharmacol. (2003) [Pubmed]
  11. Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta. Andriambeloson, E., Magnier, C., Haan-Archipoff, G., Lobstein, A., Anton, R., Beretz, A., Stoclet, J.C., Andriantsitohaina, R. J. Nutr. (1998) [Pubmed]
  12. Delphinidin inhibits endothelial cell proliferation and cell cycle progression through a transient activation of ERK-1/-2. Martin, S., Favot, L., Matz, R., Lugnier, C., Andriantsitohaina, R. Biochem. Pharmacol. (2003) [Pubmed]
  13. Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK. Oak, M.H., Bedoui, J.E., Madeira, S.V., Chalupsky, K., Schini-Kerth, V.B. Br. J. Pharmacol. (2006) [Pubmed]
  14. Gastrointestinal uptake of nasunin, acylated anthocyanin in eggplant. Ichiyanagi, T., Terahara, N., Rahman, M.M., Konishi, T. J. Agric. Food Chem. (2006) [Pubmed]
  15. Effect of clarification techniques and rat intestinal extract incubation on phenolic composition and antioxidant activity of black currant juice. Pinelo, M., Landbo, A.K., Vikbjerg, A.F., Meyer, A.S. J. Agric. Food Chem. (2006) [Pubmed]
  16. Activation of anthocyanin synthesis genes by white light in eggplant hypocotyl tissues, and identification of an inducible P-450 cDNA. Toguri, T., Umemoto, N., Kobayashi, O., Ohtani, T. Plant Mol. Biol. (1993) [Pubmed]
  17. Condensed tannins induce micronuclei in cultured V79 Chinese hamster cells. Ferguson, L.R., van Zijl, P., Holloway, W.D., Jones, W.T. Mutat. Res. (1985) [Pubmed]
  18. The polyphenolic content of fruit and vegetables and their antioxidant activities. What does a serving constitute? Paganga, G., Miller, N., Rice-Evans, C.A. Free Radic. Res. (1999) [Pubmed]
  19. Delphinidin accumulation is associated with abnormal flower development in petunias. Ando, T., Takahashi, M., Nakajima, T., Toya, Y., Watanabe, H., Kokubun, H., Tatsuzawa, F. Phytochemistry (2004) [Pubmed]
  20. Antioxidant activities of pomegranate fruit extract and its anthocyanidins: delphinidin, cyanidin, and pelargonidin. Noda, Y., Kaneyuki, T., Mori, A., Packer, L. J. Agric. Food Chem. (2002) [Pubmed]
  21. The substitution pattern of anthocyanidins affects different cellular signaling cascades regulating cell proliferation. Marko, D., Puppel, N., Tjaden, Z., Jakobs, S., Pahlke, G. Molecular nutrition & food research. (2004) [Pubmed]
  22. Anthocyanidins induce apoptosis in human promyelocytic leukemia cells: structure-activity relationship and mechanisms involved. Hou, D.X., Ose, T., Lin, S., Harazoro, K., Imamura, I., Kubo, M., Uto, T., Terahara, N., Yoshimoto, M., Fujii, M. Int. J. Oncol. (2003) [Pubmed]
  23. Induction of apoptosis by the Anthocyanidins through regulation of Bcl-2 gene and activation of c-Jun N-terminal kinase cascade in hepatoma cells. Yeh, C.T., Yen, G.C. J. Agric. Food Chem. (2005) [Pubmed]
  24. Triacylated anthocyanins from Ajuga reptans flowers and cell cultures. Terahara, N., Callebaut, A., Ohba, R., Nagata, T., Ohnishi-Kameyama, M., Suzuki, M. Phytochemistry (1996) [Pubmed]
  25. Identification of anthocyanins in Rhamnus alaternus L. berries. Longo, L., Vasapollo, G., Rescio, L. J. Agric. Food Chem. (2005) [Pubmed]
  26. Tentative identification of polyphenols in Sempervivum tectorum and assessment of the antimicrobial activity of Sempervivum L. Abram, V., Donko, M. J. Agric. Food Chem. (1999) [Pubmed]
  27. Delphinidin 3-O-(2-O-beta-D-Glucopyranosyl-alpha-l-arabinopyranoside): a novel anthocyanin identified in Beluga black lentils. Takeoka, G.R., Dao, L.T., Tamura, H., Harden, L.A. J. Agric. Food Chem. (2005) [Pubmed]
  28. Differential response related to genotoxicity between eggplant (Solanum melanogena) skin aqueous extract and its main purified anthocyanin (delphinidin) in vivo. Azevedo, L., Alves de Lima, P.L., Gomes, J.C., Stringheta, P.C., Ribeiro, D.A., Salvadori, D.M. Food Chem. Toxicol. (2007) [Pubmed]
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