Disease relevance of acetylene

• Lembehyne A, a spongean polyacetylene, induces neuronal differentiation in neuroblastoma cell [1].
• We investigated the possible mechanisms by which petrotetrayndiol A, a polyacetylene from the sponge Petrosia sp., exerts its anti-proliferative activity in cultured SK-MEL-2 human melanoma cells [2].
• The effects of polyacetylene on DNA replication were examined using simian virus 40 DNA replication system in vitro [3].
• The polyacetylene 8S-heptadeca-2(Z)-9(Z)-diene-4,6-diyne-1,8-diol exhibited toxicity for A. salina and specific antibiotic activity against Gram-positive bacteria [4].

High impact information on acetylene

• Using a simple model for the polaron, similar to that used for conjugated polymers such as polyacetylene, we show that, for reasonable values of the parameters, an injected electron or hole can form a polaron on a DNA stack [5].
• The esterification enantioselectively proceeded through chirality transfer from the induced helical conformation or the helicity memory of the polyacetylene backbone [6].
• Inhibition of cyclooxygenase-2 and telomerase activities in human leukemia cells by dideoxypetrosynol A, a polyacetylene from the marine sponge Petrosia sp [7].
• Dideoxypetrosynol A, a polyacetylene from the marine sponge Petrosia sp., is known to exhibit significant selective cytotoxic activity against several human cancer cell lines [7].
• Polyacetylene analogs, isolated from hairy roots of Panax ginseng, inhibit Acyl-CoA : cholesterol acyltransferase [8].

Biological context of acetylene

• Lembehyne A (LB-A), a spongean polyacetylene, induced neuronal cell differentiation in a neuroblastoma cell line, Neuro 2A [1].
• Induction of apoptosis by dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp., in human skin melanoma cells [9].
• Suppression of U937 human monocytic leukemia cell growth by dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp., via induction of Cdk inhibitor p16 and down-regulation of pRB phosphorylation [10].
• Rapid fabrication of three-dimensional porous films with biomimetic patterns by natural evaporation of amphiphilic polyacetylene solutions under ambient conditions [11].

Anatomical context of acetylene

• Dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp., is known to exhibit significant selective cytotoxicity against several human tumor cell lines [9].

Associations of acetylene with other chemical compounds

• After two or three years' cultivation, main essential oil components, i.e., the sesquiterpenes: elemol ( 1), atractylon ( 2), hinesol ( 3), beta -eudesmol ( 4), selina-4(14),7(11)-dien-8-one ( 5), and the polyacetylene of atractylodin ( 6) were determined by capillary gas chromatography [12].
• Effects of the polyacetylene capillin on human tumour cell lines [13].
• Two polyacetylene glycosides, lobetyol 9-O-glc(6)-(1)rha (pratialin-A) and lobetyol 9-O-glc(6)-(1)glc(6)-(1)glc (pratialin-B), were isolated from Pratia nummularia (Campanulaceae) callus and hairy root cultures and their chemical structures were determined by analysis of spectroscopic data [14].
• Use of on-flow LC/1H NMR for the study of an antioxidant fraction from Orophea enneandra and isolation of a polyacetylene, lignans, and a tocopherol derivative [15].
• During a study on the chemistry and biological activity of Kuwaiti plants, new metabolites including 4,6-dihydroxy-3-[3'-methyl-2'-butenyl]-5-[4''-hydroxy-3''-methyl-2''-butenyl]-cinnamic acid (1), the 3R,8R stereoisomer of the C17 polyacetylene dehydrofalcarindiol (2) and a C10 polyacetylene glucoside (3) were characterised by spectroscopic means [16].

Gene context of acetylene

• Gymnasterkoreayne G, a new inhibitory polyacetylene against NFAT transcription factor from Gymnaster koraiensis [17].
• AFM snapshots of synthetic multifunctional pores with polyacetylene blockers: pseudorotaxanes and template effects [18].

Analytical, diagnostic and therapeutic context of acetylene

• Ethanol extract showed by HPLC the presence of several peaks for polyacetylene and flavonoids, compounds corresponding to quercetin-3,3'-dimethoxy-7-0-rhamnoglucopyranose and the acetylene 1-phenyl-1,3-diyn-5-en-7-ol-acetate, previously identified in this extract [19].

References