Disease relevance of Angelica sinensis

• Use of dong quai (Angelica sinensis) to treat peri- or postmenopausal symptoms in women with breast cancer: is it appropriate [1]?
• This study has demonstrated for the first time that Angelica sinensis inhibits the progress of radiation-induced pulmonary fibrosis, possibly by down-regulating the expression of the proinflammatory cytokine Tgfb1 [2].
• Intra-gastric administration of Angelica sinensis polysaccharides-enriched fraction (AP) at the doses of 50 or 75 mg/kg dose-dependently prevented liver toxicity induced by acetaminophen in mice but did not affect the serum acetaminophen concentration [3].

Psychiatry related information on Angelica sinensis

• The effects of the methanolic extract of Radix Angelica Sinensis (Umbellifera) (abbreviated as RAS extract) and n-hexane fraction of RAS extract (RAS(H) fraction) on the various drugs-induced amnesia in rats were studied by using passive avoidance task [4].

High impact information on Angelica sinensis

• It has been reported that an extract from Angelica sinensis mainly consisting of polysaccharides (95%) prevented ethanol- or indomethacin-induced gastric mucosal damage (Cho CH et al. Planta Med 2000;66:348-51) [5].
• Assay of free ferulic acid and total ferulic acid for quality assessment of Angelica sinensis [6].
• Identification and comparative determination of senkyunolide A in traditional Chinese medicinal plants Ligusticum chuanxiong and Angelica sinensis by HPLC coupled with DAD and ESI-MS [7].
• Using the HPLC/DAD/ESI/MS method, the qualitative and quantitative analysis of senkyunolide A (SA) in the rhizomes of Ligusticum chuanxiong (Rhizoma chuanxiong; CX) and roots of Angelica sinensis (DG) was established [7].
• Experiments showed that the Angelica sinensis polysaccharide was composed of fucose, galactose, glucose, arabinose, rhamnose and xylose (mole ratio 1.0:13.6:15.0:8.7:21.3:3.7), and the flax polysaccharide was composed of galactose, glucose and arabinose (mole ratio 1.0:4.98:1.1) [8].

Biological context of Angelica sinensis

• Danggui (Angelica sinensis) affects the pharmacodynamics but not the pharmacokinetics of warfarin in rabbits [9].

Anatomical context of Angelica sinensis

• OBJECTIVE: To investigate the effects of Angelica sinensis (Oliv.) on melanocytes and tyrosinase activity [10].
• Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice [11].

Associations of Angelica sinensis with chemical compounds

• Protective effect of angelica sinensis polysaccharide on experimental immunological colon injury in rats [12].
• In this paper, capillary zone electrophoresis with amperometric detection (CZE-AD) was applied to determine the compositions of hetero-polysaccharides from Chinese herbs, Angelica sinensis and flax by analyzing their hydrolyzed monosaccharides: fucose, galactose, glucose, arabinose, rhamnose and xylose [8].
• Actually, ferulic acid and ligustilide are considered as major active components in Angelica sinensis [13].
• Screening and analysis of permeable compounds in Radix Angelica Sinensis with immobilized liposome chromatography [14].
• Aqueous extracts of Angelica sinensis root, a herb commonly used in the treatment of vitiligo in Traditional Chinese Medicine, were tested for their activity on mouse melanocyte proliferation in culture [15].

Gene context of Angelica sinensis

• Under most treatments, the cells presented very pale expression for cyclooxygenase-2 (Cox 2) protein; slightly intensified band showed at the highest Angelica sinensis concentration, 1.0 mg/ml during the course of culture [16].

References