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MeSH Review

Tanacetum parthenium

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Disease relevance of Tanacetum parthenium


High impact information on Tanacetum parthenium

  • Feverfew did not inhibit the secretion induced in platelets or PMNs by the calcium ionophore A23187 [5].
  • Feverfew also inhibited release of vitamin B12-binding protein from PMNs induced by the secretagogues formyl-methionyl-leucyl-phenylalanine, sodium arachidonate, and zymosan-activated serum [5].
  • Extract of feverfew inhibits prostaglandin biosynthesis [6].
  • Here we show that the anti-inflammatory sesquiterpene lactone parthenolide derived from the European traditional herb-medicine feverfew and many Mexican India medicinal plants suppresses expression of the CD95L and CD95 at the mRNA levels, thus, preventing T-cells from AICD [7].
  • The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase [8].

Chemical compound and disease context of Tanacetum parthenium

  • Efficacy and safety of 6.25 mg t.i.d. feverfew CO2-extract (MIG-99) in migraine prevention--a randomized, double-blind, multicentre, placebo-controlled study [9].
  • Data and expert opinion are mixed regarding some agents, such as verapamil and feverfew; these can be considered in migraine prevention when other medications cannot be used [10].

Biological context of Tanacetum parthenium


Anatomical context of Tanacetum parthenium


Associations of Tanacetum parthenium with chemical compounds

  • The primary objective was to show a dose-response of a new stable extract (MIG-99) reproducibly manufactured with supercritical CO2 from feverfew (T. parthenium) [13].
  • Natural anti-inflammatory compounds abound in the herbal world and are found in green tea, the spices turmeric and rosemary, feverfew and others [14].
  • 17 patients with + +/+ + + reactions to feverfew and parthenolide were tested with 15 selected monoterpenes and 2 sesquiterpenes [4].
  • Inhibition of anti-IgE-induced histamine release by feverfew extract was observed when the drug was added simultaneously with anti-IgE and the inhibitory activity increased only slightly when the drug was preincubated with the cells for 5 min before anti-IgE stimulation [12].
  • At 10-25 micrograms ml-1 feverfew had no effect on the formation of arachidonate metabolites while at highest concentrations (50-200 micrograms ml-1) it inhibited both cyclo-oxygenase and lipoxygenase metabolic products [15].

Gene context of Tanacetum parthenium


Analytical, diagnostic and therapeutic context of Tanacetum parthenium

  • Testing with the individual ingredients of the Compositae mix showed frequent positive patch test reactions to feverfew, followed in order by chamomile, tansy, yarrow and arnica [21].
  • The isolated rat stomach fundus preparation, a sensitive bioassay to evaluate serotonin-(5-HT) like activity, was used as a model to study the effects of parthenolide (PAR), a component to Tanacetum parthenium (feverfew), on 5-HT storage, release and stimulation of the 5-HT2B receptor [22].


  1. Nuclear factor-kappaB as a molecular target for migraine therapy. Reuter, U., Chiarugi, A., Bolay, H., Moskowitz, M.A. Ann. Neurol. (2002) [Pubmed]
  2. Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide. Patel, N.M., Nozaki, S., Shortle, N.H., Bhat-Nakshatri, P., Newton, T.R., Rice, S., Gelfanov, V., Boswell, S.H., Goulet, R.J., Sledge, G.W., Nakshatri, H. Oncogene (2000) [Pubmed]
  3. Parthenolide and abscisic acid synthesis in feverfew are associated but environmental factors affect them dissimilarly. Fonseca, J.M., Rushing, J.W., Rajapakse, N.C., Thomas, R.L., Riley, M.B. J. Plant Physiol. (2005) [Pubmed]
  4. Do monoterpenes released from feverfew (Tanacetum parthenium) plants cause airborne Compositae dermatitis? Paulsen, E., Christensen, L.P., Andersen, K.E. Contact Derm. (2002) [Pubmed]
  5. Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes. Heptinstall, S., White, A., Williamson, L., Mitchell, J.R. Lancet (1985) [Pubmed]
  6. Extract of feverfew inhibits prostaglandin biosynthesis. Collier, H.O., Butt, N.M., McDonald-Gibson, W.J., Saeed, S.A. Lancet (1980) [Pubmed]
  7. The anti-inflammatory sesquiterpene lactone parthenolide suppresses CD95-mediated activation-induced-cell-death in T-cells. Li-Weber, M., Giaisi, M., Baumann, S., Treiber, M.K., Krammer, P.H. Cell Death Differ. (2002) [Pubmed]
  8. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Kwok, B.H., Koh, B., Ndubuisi, M.I., Elofsson, M., Crews, C.M. Chem. Biol. (2001) [Pubmed]
  9. Efficacy and safety of 6.25 mg t.i.d. feverfew CO2-extract (MIG-99) in migraine prevention--a randomized, double-blind, multicentre, placebo-controlled study. Diener, H.C., Pfaffenrath, V., Schnitker, J., Friede, M., Henneicke-von Zepelin, H.H. Cephalalgia : an international journal of headache. (2005) [Pubmed]
  10. Medications for migraine prophylaxis. Modi, S., Lowder, D.M. American family physician. (2006) [Pubmed]
  11. Comparative effects of the herbal constituent parthenolide (Feverfew) on lipopolysaccharide-induced inflammatory gene expression in murine spleen and liver. Smolinski, A.T., Pestka, J.J. Journal of inflammation (London, England) (2005) [Pubmed]
  12. The activity of compounds extracted from feverfew on histamine release from rat mast cells. Hayes, N.A., Foreman, J.C. J. Pharm. Pharmacol. (1987) [Pubmed]
  13. The efficacy and safety of Tanacetum parthenium (feverfew) in migraine prophylaxis--a double-blind, multicentre, randomized placebo-controlled dose-response study. Pfaffenrath, V., Diener, H.C., Fischer, M., Friede, M., Henneicke-von Zepelin, H.H. Cephalalgia : an international journal of headache. (2002) [Pubmed]
  14. Herbals, cancer prevention and health. Wargovich, M.J., Woods, C., Hollis, D.M., Zander, M.E. J. Nutr. (2001) [Pubmed]
  15. The effect of an aqueous extract of Tanacetum parthenium L. on arachidonic acid metabolism by rat peritoneal leucocytes. Capasso, F. J. Pharm. Pharmacol. (1986) [Pubmed]
  16. Feverfew extracts and the sesquiterpene lactone parthenolide inhibit intercellular adhesion molecule-1 expression in human synovial fibroblasts. Piela-Smith, T.H., Liu, X. Cell. Immunol. (2001) [Pubmed]
  17. 5-Hydroxytryptamine-inhibiting property of Feverfew: role of parthenolide content. Mittra, S., Datta, A., Singh, S.K., Singh, A. Acta Pharmacol. Sin. (2000) [Pubmed]
  18. Feverfew in rheumatoid arthritis: a double blind, placebo controlled study. Pattrick, M., Heptinstall, S., Doherty, M. Ann. Rheum. Dis. (1989) [Pubmed]
  19. Immediate hypersensitivity to Parthenium hysterophorus. II. Clinical studies on the prevalence of Parthenium rhinitis. Sriramarao, P., Nagpal, S., Rao, B.S., Prakash, O., Rao, P.V. Clin. Exp. Allergy (1991) [Pubmed]
  20. Transport of parthenolide across human intestinal cells (Caco-2). Khan, S.I., Abourashed, E.A., Khan, I.A., Walker, L.A. Planta Med. (2003) [Pubmed]
  21. Compositae dermatitis in a Danish dermatology department in one year (I). Results of routine patch testing with the sesquiterpene lactone mix supplemented with aimed patch testing with extracts and sesquiterpene lactones of Compositae plants. Paulsen, E., Andersen, K.E., Hausen, B.M. Contact Derm. (1993) [Pubmed]
  22. Parthenolide inhibits the contractile responses of rat stomach fundus to fenfluramine and dextroamphetamine but not serotonin. Béjar, E. Journal of ethnopharmacology. (1996) [Pubmed]
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