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MeSH Review

Calotropis

 
 
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Disease relevance of Calotropis

  • A chloroform-soluble fraction from Calotropis procera roots showed significant dose-related antiinflammatory activity in rats using the pharmacologic models of carrageenin-induced pedal oedema, cotton pellet granuloma and formaldehyde-induced arthritis [1].
  • Pretreatment with an ethanolic latex extract of Calotropis procera at a dose of 300 mg/kg body wt., administered orally thrice a day for 30 days, reduced significantly (p < 0.01) the elevated marker enzyme levels in serum and heart homogenates in isoproterenol-induced myocardial infarction [2].
 

High impact information on Calotropis

  • The three-dimensional structure of the sulfhydryl protease calotropin DI from the madar plant, Calotropis gigantea, has been determined at 3.2 A resolution using the multiple isomorphous replacement method with five heavy atom derivatives [3].
  • Identification of a novel cardenolide (2''-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: structure-activity relationship analyses [4].
  • The structural and functional aspects along with equilibrium unfolding of procerain, a cysteine protease from Calotropis procera, were studied in solution [5].
  • Latex from Calotropis procera is widely used in folk medicine as a rich source of biologically active compounds capable of promoting diverse benefits such as control of dermal fungal infections, antimicrobial activities and pain relief among other useful properties [6].
  • The latex of the plant Calotropis procera has been reported to exhibit potent antiinflammatory activity against carrageenin and formalin that are known to release various mediators [7].
 

Anatomical context of Calotropis

 

Associations of Calotropis with chemical compounds

  • Analysis of the methanolic extract of Calotropis procera root barks enabled the identification of a novel cardenolide (2''-oxovoruscharin) to be made [4].
  • Flavonol glycosides from Calotropis gigantea [11].
  • Histamine mediates the pro-inflammatory effect of latex of Calotropis procera in rats [12].
  • The n-butanol extract of Calotropis procera flowers and the aqueous extract of Eugenia caryophyllata proved to be the most effective against the bacteria tested [13].
  • It was found that Calotropis procera flowers possess good anthelmintic activity against nematodes, yet it was lower than that exhibited by levamisole (97.8-100%) [14].
 

Gene context of Calotropis

  • Studies on the possible mechanism of the gastric mucosal protection by Calotropis procera--involvement of 5-lipoxygenase pathway [15].
  • Extracts of the flowers of Calotropis procera (Ait.) R [16].
  • Two proteinase containing carbohydrate, called calotropain-FI and calotropain-FII, were purified from Calotropis gigantea latex by CM-Sephadex C-50 chromatography [17].

References

  1. Preliminary studies on the antiinflammatory and analgesic activities of Calotropis procera root extract. Basu, A., Chaudhuri, A.K. Journal of ethnopharmacology. (1991) [Pubmed]
  2. Effect of Calotropis procera latex on isoproterenol induced myocardial infarction in albino rats. Ahmed, K.K., Rana, A.C., Dixit, V.K. Phytomedicine (2004) [Pubmed]
  3. Crystal and molecular structure of the sulfhydryl protease calotropin DI at 3.2 A resolution. Heinemann, U., Pal, G.P., Hilgenfeld, R., Saenger, W. J. Mol. Biol. (1982) [Pubmed]
  4. Identification of a novel cardenolide (2''-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: structure-activity relationship analyses. Van Quaquebeke, E., Simon, G., André, A., Dewelle, J., Yazidi, M.E., Bruyneel, F., Tuti, J., Nacoulma, O., Guissou, P., Decaestecker, C., Braekman, J.C., Kiss, R., Darro, F. J. Med. Chem. (2005) [Pubmed]
  5. Differences in the unfolding of procerain induced by pH, guanidine hydrochloride, urea, and temperature. Dubey, V.K., Jagannadham, M.V. Biochemistry (2003) [Pubmed]
  6. Anti-inflammatory effect of the latex from Calotropis procera in three different experimental models: peritonitis, paw edema and hemorrhagic cystitis. Alencar, N.M., Figueiredo, I.S., Vale, M.R., Bitencurt, F.S., Oliveira, J.S., Ribeiro, R.A., Ramos, M.V. Planta Med. (2004) [Pubmed]
  7. Antiinflammatory efficacy of extracts of latex of Calotropis procera against different mediators of inflammation. Arya, S., Kumar, V.L. Mediators of inflammation. (2005) [Pubmed]
  8. Calotropis procera latex-induced inflammatory hyperalgesia--effect of antiinflammatory drugs. Sehgal, R., Kumar, V.L. Mediators of inflammation. (2005) [Pubmed]
  9. Calotropis procera (ushaar) keratitis. Al-Mezaine, H.S., Al-Rajhi, A.A., Al-Assiri, A., Wagoner, M.D. Am. J. Ophthalmol. (2005) [Pubmed]
  10. Cytotoxic principles of a Bangladeshi crude drug, akond mul (roots of Calotropis gigantea L.). Kiuchi, F., Fukao, Y., Maruyama, T., Obata, T., Tanaka, M., Sasaki, T., Mikage, M., Haque, M.E., Tsuda, Y. Chem. Pharm. Bull. (1998) [Pubmed]
  11. Flavonol glycosides from Calotropis gigantea. Sen, S., Sahu, N.P., Mahato, S.B. Phytochemistry (1992) [Pubmed]
  12. Histamine mediates the pro-inflammatory effect of latex of Calotropis procera in rats. Shivkar, Y.M., Kumar, V.L. Mediators of inflammation. (2003) [Pubmed]
  13. Antibacterial activity of some Moroccan medicinal plants. Larhsini, M., Oumoulid, L., Lazrek, H.B., Wataleb, S., Bousaid, M., Bekkouche, K., Jana, M. Phytotherapy research : PTR. (2001) [Pubmed]
  14. Anthelmintic activity of Calotropis procera (Ait.) Ait. F. flowers in sheep. Iqbal, Z., Lateef, M., Jabbar, A., Muhammad, G., Khan, M.N. Journal of ethnopharmacology. (2005) [Pubmed]
  15. Studies on the possible mechanism of the gastric mucosal protection by Calotropis procera--involvement of 5-lipoxygenase pathway. Sen, T., Basu, A., Chaudhuri, A.K. Fundamental & clinical pharmacology. (1998) [Pubmed]
  16. Ayurvedic herbal drugs with possible cytostatic activity. Smit, H.F., Woerdenbag, H.J., Singh, R.H., Meulenbeld, G.J., Labadie, R.P., Zwaving, J.H. Journal of ethnopharmacology. (1995) [Pubmed]
  17. Studies on proteinases from Calotropis gigantea latex. I. Purification and some properties of two proteinases containing carbohydrate. Abraham, K.I., Joshi, P.N. Biochim. Biophys. Acta (1979) [Pubmed]
 
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