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MeSH Review

Mannosidase Deficiency Diseases

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Disease relevance of Mannosidase Deficiency Diseases


High impact information on Mannosidase Deficiency Diseases


Chemical compound and disease context of Mannosidase Deficiency Diseases

  • The structures of the digestion intermediates are compared with the published structures of the storage products in mannosidosis and of intact asparagine-linked glycans [10].
  • O-alpha-D-Mannopyranosyl-(1----6)-O-beta-D-mannopyranosyl-(1----4)-O-(2- acetamido-2-deoxy-beta-D-glucopyranosyl)-(1----4)-2-acetamido-2-deoxy- D-glucopyranose was isolated from bovine or ovine mannosidosis urine [11].
  • Use of EDTA blood samples for mannosidosis testing [12].
  • Mannose and glucosamine-containing oligosaccharides were extracted from tissues of variously aged calves with mannosidosis [13].
  • Skin fibroblasts from healthy individuals and a mannosidosis patient were cultured in the presence of [2-3H] mannose and the cell homogenates were fractionated by trichloroacetic acid precipitation into a precipitable and a non-precipitable portion [14].

Anatomical context of Mannosidase Deficiency Diseases


Gene context of Mannosidase Deficiency Diseases

  • Heterogeneity of urinary oligosaccharides from mannosidosis: mass spectrometric analysis of permethylated Man9, Man8, and Man7 derivatives [16].


  1. Pancytopenia in mannosidosis. Press, O.W., Fingert, H., Lott, I.T., Dickersin, C.R. Arch. Intern. Med. (1983) [Pubmed]
  2. Mannosidosis: isolation and comparison of mannose-containing oligosaccharides from gingiva and urine. Daniel, P.F., Defeudis, D.F., Lott, I.T. Eur. J. Biochem. (1981) [Pubmed]
  3. Direct enzyme transfer from lymphocytes corrects a lysosomal storage disease. Abraham, D., Muir, H., Olsen, I., Winchester, B. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
  4. Pulsed amperometric detection of carbohydrates in lysosomal storage disease fibroblasts: a new screening technique for carbohydrate storage diseases. Blom, H.J., Andersson, H.C., Krasnewich, D.M., Gahl, W.A. J. Chromatogr. (1990) [Pubmed]
  5. Glycopeptide storage in skin fibroblasts cultured from a patient with alpha-mannosidase deficiency. Tsay, G.C., Dawson, G., Matalon, R. J. Clin. Invest. (1975) [Pubmed]
  6. Letter: Mannosidosis and maternal penicillamine therapy. Arbisser, A.I., Scott, C.I., Howell, B.R. Lancet (1976) [Pubmed]
  7. Apparently normal extracellular acidic alpha-mannosidase in fibroblast cultures from patients with mannosidosis. Ben-Yoseph, Y., DeFranco, C.L., Charrow, J., Hahn, L.C., Nadler, H.L. Am. J. Hum. Genet. (1982) [Pubmed]
  8. Mannosidosis: assignment of the lysosomal alpha-mannosidase B gene to chromosome 19 in man. Champion, M.J., Shows, T.B. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  9. Animal model of human disease. Mannosidosis. Swainsonine-induced mannosidosis. Huxtable, C.R., Dorling, P.R. Am. J. Pathol. (1982) [Pubmed]
  10. The substrate-specificity of human lysosomal alpha-D-mannosidase in relation to genetic alpha-mannosidosis. al Daher, S., de Gasperi, R., Daniel, P., Hall, N., Warren, C.D., Winchester, B. Biochem. J. (1991) [Pubmed]
  11. Synthesis of the tetrasaccharide lipid intermediate P1-dolichyl P2-[O-alpha-D-mannopyranosyl-(1----6)-O-beta-D-mannopyranosyl-(1----4) -O-(2- acetamido-2-deoxy-beta-D-glucopyranosyl)-(1----4)-2-acetamido-2- deoxy-alpha-D-glucopyranosyl] diphosphate. Warren, C.D., Nakabayashi, S., Jeanloz, R.W. Carbohydr. Res. (1987) [Pubmed]
  12. Use of EDTA blood samples for mannosidosis testing. Healy, P.J., Butrej, P.J. Aust. Vet. J. (1979) [Pubmed]
  13. Mannosidosis: patterns of storage and urinary excretion of oligosaccharides in the bovine model. Jolly, R.D., Slack, P.M., Winter, P.J., Murphy, C.E. The Australian journal of experimental biology and medical science. (1980) [Pubmed]
  14. Storage of mannose-containing material in cultured human mannosidosis cells and metabolic correction by pig kidney alpha-mannosidase. Mersmann, G., Von Figura, K., Buddecke, E. Hoppe-Seyler's Z. Physiol. Chem. (1976) [Pubmed]
  15. Lysosomal storage disease caused by Sida carpinifolia poisoning in goats. Driemeier, D., Colodel, E.M., Gimeno, E.J., Barros, S.S. Vet. Pathol. (2000) [Pubmed]
  16. Heterogeneity of urinary oligosaccharides from mannosidosis: mass spectrometric analysis of permethylated Man9, Man8, and Man7 derivatives. Egge, H., Michalski, J.C., Strecker, G. Arch. Biochem. Biophys. (1982) [Pubmed]
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