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Gene Review

MAN2C1  -  mannosidase, alpha, class 2C, member 1

Homo sapiens

Synonyms: Alpha mannosidase 6A8B, Alpha-D-mannoside mannohydrolase, Alpha-mannosidase 2C1, MAN6A8, MANA, ...
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Disease relevance of MAN2C1

  • RESULTS: We report the refinement of the linkage region for keratoconus with cataract to an interval of approximately 5.5 Mb flanked by the MAN2C1 gene and the D15S211 marker on chromosome 15q [1].
  • Fibroblasts from patients with mannosidosis, cultured in medium supplemented with fetal calf serum from which acidic alpha-mannosidase (alpha-D-mannoside mannohydrolase, E.C. has been removed, secreted a normal amount of apparently unaffected acidic alpha-mannosidase into fetal calf serum-free medium [2].
  • The deduced primary structure of MANA revealed a 458-amino acid sequence that exhibited identity with Bacillus and Pseudomonas fluorescens subsp. cellulosa mannanases belonging to glycosyl hydrolase Family 26 [3].

High impact information on MAN2C1

  • Histochemical localization of acidic alpha-D-mannoside mannohydrolase (EC 3.2. 1.24), using 5-bromo-4-chloro-3-indolyl alpha-D-mannopyranoside, showed that functional enzyme was present in neurons, glial cells, and cells associated with blood vessels [4].
  • Human alpha-mannosidase activity (alpha-D-mannoside mannohydrolase, EC from tissues and cultured skin fibroblasts was separated by gel electrophoresis into a neutral, cytoplasmic form (alpha-mannosidase A) and two closely related acidic, lysosomal components (alpha-mannosidase B) [5].
  • Analysis of truncated derivatives of MANA confirmed that the N-terminal 458-residue sequence constituted the catalytic domain, while the C-terminal domain was not essential for the retention of catalytic activity [3].
  • Two cDNAs, designated xynA and manA, encoding xylanase A (XYLA) and mannanase A (MANA), respectively, were isolated from a cDNA library derived from mRNA extracted from the anaerobic fungus, Piromyces [3].
  • The nucleotide sequences of xynA and manA revealed open reading frames of 1875 and 1818 base pairs, respectively, coding for proteins of M(r) 68,049 (XYLA) and 68,055 (MANA) [3].

Biological context of MAN2C1

  • Changes in xanthophyll esterification degree during pepper fruit ripening have been studied in five cultivars (Numex, Mana, Belrubi, Delfin, and Negral) [6].
  • The tissue distribution and some properties of human alpha-mannosidase (alpha-D-mannoside mannohydrolase EC have been studied [7].
  • This paper reports the preliminary findings on the reproductive performance of 52 Bhotia women from the Mana Valley (Uttar Pradesh; elevation 10 560 ft.), who had approached menopause [8].

Anatomical context of MAN2C1


Associations of MAN2C1 with chemical compounds

  • Assignment of cytoplasmic alpha-mannosidase (MANA) and confirmation of mitochondrial isocitrate dehydrogenase (IDHM) to the q11 leads to qter region of chromosome 15 in man [12].
  • The asparagine-linked oligosaccharides on tissue factor pathway inhibitor terminate with SO4-4GalNAc beta 1, 4GlcNAc beta 1,2 Mana alpha [13].
  • Quantitatively, Negral cultivar showed the highest increase in total carotenoid content (48. 39-fold), followed by Mana and Delfin with 38.03- and 36.8-fold, respectively, and by Belrubi and Numex with 28.03- and 23.48-fold, respectively [14].
  • In the present study, the cultivar Mana had the highest total carotenoid content (13 208 mg/kg dwt), but the lowest R/Y (1.25) and Caps/Zeax (3.38) ratios, which are therefore the parameters to improve [14].
  • Alpha-D-Mannosidase (alpha-D-mannoside mannohydrolase, EC has been purified to homogeneity as demonstrated by polyacrylamide gel electrophoresis and ultracentrifugation [15].


  1. Fine mapping of the keratoconus with cataract locus on chromosome 15q and candidate gene analysis. Dash, D.P., Silvestri, G., Hughes, A.E. Mol. Vis. (2006) [Pubmed]
  2. Apparently normal extracellular acidic alpha-mannosidase in fibroblast cultures from patients with mannosidosis. Ben-Yoseph, Y., DeFranco, C.L., Charrow, J., Hahn, L.C., Nadler, H.L. Am. J. Hum. Genet. (1982) [Pubmed]
  3. The conserved noncatalytic 40-residue sequence in cellulases and hemicellulases from anaerobic fungi functions as a protein docking domain. Fanutti, C., Ponyi, T., Black, G.W., Hazlewood, G.P., Gilbert, H.J. J. Biol. Chem. (1995) [Pubmed]
  4. Bone marrow transplantation corrects the enzyme defect in neurons of the central nervous system in a lysosomal storage disease. Walkley, S.U., Thrall, M.A., Dobrenis, K., Huang, M., March, P.A., Siegel, D.A., Wurzelmann, S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  5. Mannosidosis: assignment of the lysosomal alpha-mannosidase B gene to chromosome 19 in man. Champion, M.J., Shows, T.B. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  6. Xanthophyll esterification accompanying carotenoid overaccumulation in chromoplast of Capsicum annuum ripening fruits is a constitutive process and useful for ripeness index. Hornero-Méndez, D., Mínguez-Mosquera, M.I. J. Agric. Food Chem. (2000) [Pubmed]
  7. The relationship between different forms of human alpha-mannosidase. Chester, M.A., Lundblad, A., Masson, P.K. Biochim. Biophys. Acta (1975) [Pubmed]
  8. Reproductive performance of Bhotia women of Mana Valley. Singh, L. Anthropologischer Anzeiger; Bericht über die biologisch-anthropologische Literatur. (1984) [Pubmed]
  9. Inhibition of the alpha-mannosidase Man2c1 gene expression enhances adhesion of Jurkat cells. Qu, L., Ju, J.Y., Chen, S.L., Shi, Y., Xiang, Z.G., Zhou, Y.Q., Tian, Y., Liu, Y., Zhu, L.P. Cell Res. (2006) [Pubmed]
  10. Alpha-mannosidase in human red cells. Poenaru, L., Dreyfus, J.C. Biochim. Biophys. Acta (1979) [Pubmed]
  11. Amount and properties of uptake forms in preparations of alpha-mannosidase from pig kidney. Mersmann, G., Becker, R., Buddecke, E. Biochim. Biophys. Acta (1978) [Pubmed]
  12. Assignment of cytoplasmic alpha-mannosidase (MANA) and confirmation of mitochondrial isocitrate dehydrogenase (IDHM) to the q11 leads to qter region of chromosome 15 in man. Champion, M.J., Brown, J.A., Shows, T.B. Cytogenet. Cell Genet. (1978) [Pubmed]
  13. The asparagine-linked oligosaccharides on tissue factor pathway inhibitor terminate with SO4-4GalNAc beta 1, 4GlcNAc beta 1,2 Mana alpha. Smith, P.L., Skelton, T.P., Fiete, D., Dharmesh, S.M., Beranek, M.C., MacPhail, L., Broze, G.J., Baenziger, J.U. J. Biol. Chem. (1992) [Pubmed]
  14. Carotenoid biosynthesis changes in five red pepper (Capsicum annuum L.) cultivars during ripening. Cultivar selection for breeding. Hornero-Méndez, D., Gómez-Ladrón De Guevara, R., Mínguez-Mosquera, M.I. J. Agric. Food Chem. (2000) [Pubmed]
  15. Alpha-D-Mannosidase. Preparation and properties of free and insolubilized enzyme. Sheperd, V., Montgomery, R. Biochim. Biophys. Acta (1976) [Pubmed]
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