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MeSH Review

Microscopy, Energy-Filtering Transmission Electron

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Gene context of Microscopy, Energy-Filtering Transmission Electron

  • Here we show, using electron spectroscopic imaging, that DNA-PKcs and Ku interact with multiple DNA molecules to form large protein-DNA complexes that converge at the base of multiple DNA loops [14].
  • Electron spectroscopic imaging showed that ERK site UBF mutants do not induce the characteristic DNA looping of the enhancesome and associate with no more than half of the enhancesomal DNA [15].
  • In support of this concept, electron spectroscopic imaging studies of the nitrogen and phosphorus distribution in the nucleolar granular component revealed regions that are very rich in protein and yet devoid of nucleic acid [16].
  • Electron spectroscopic imaging analysis of TFIIIA:DNA complexes indicate that TFIIIA binding involves compaction of the 5 S promoter into a precise three-dimensional hairpin-shaped structure [17].
  • It is also shown that, complementary methods (such as TEM and EFTEM) giving structural and chemical information on a larger scale must be applied to explain the good properties of the steel after prolonged aging [18].

Analytical, diagnostic and therapeutic context of Microscopy, Energy-Filtering Transmission Electron


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  2. Promyelocytic leukemia (PML) nuclear bodies are protein structures that do not accumulate RNA. Boisvert, F.M., Hendzel, M.J., Bazett-Jones, D.P. J. Cell Biol. (2000) [Pubmed]
  3. Molecular immunolabeling with recombinant single-chain variable fragment (scFv) antibodies designed with metal-binding domains. Malecki, M., Hsu, A., Truong, L., Sanchez, S. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. High resolution ultrastructural mapping of total calcium: electron spectroscopic imaging/electron energy loss spectroscopy analysis of a physically/chemically processed nerve-muscle preparation. Grohovaz, F., Bossi, M., Pezzati, R., Meldolesi, J., Tarelli, F.T. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. Cortical plaque-like structures identify ribosome-containing domains in the Mauthner cell axon. Koenig, E., Martin, R. J. Neurosci. (1996) [Pubmed]
  6. Electron spectroscopic imaging and X-ray microanalysis of phosphorus in mouse sperm chromatin. Rouelle-Rossier, V.B., Biggiogera, M. European journal of histochemistry : EJH. (1992) [Pubmed]
  7. The ultrastructure of chicken gizzard vinculin as visualized by high-resolution electron microscopy. Winkler, J., Lünsdorf, H., Jockusch, B.M. J. Struct. Biol. (1996) [Pubmed]
  8. Ultrastructural distribution of terbium across capillary endothelium: detection by electron spectroscopic imaging and electron energy loss spectroscopy. Wagner, R.C., Chen, S.C. J. Histochem. Cytochem. (1990) [Pubmed]
  9. Modeling the 3-D RNA distribution in the Balbiani ring granule. Olins, A.L., Olins, D.E., Olman, V., Levy, H.A., Bazett-Jones, D.P. Chromosoma (1994) [Pubmed]
  10. Chloride is preferentially accumulated in a subpopulation of dendrites and periglomerular cells of the main olfactory bulb in adult rats. Siklós, L., Rickmann, M., Joó, F., Freeman, W.J., Wolff, J.R. Neuroscience (1995) [Pubmed]
  11. Specific visualization of precipitated cerium by energy-filtered transmission electron microscopy for detection of alkaline phosphatase in immunoenzymatic double labeling of tyrosine hydroxylase and serotonin in the rat olfactory bulb. Radcke, C., Stroh, T., Dworkowski, F., Veh, R.W. Histochem. Cell Biol. (2002) [Pubmed]
  12. Zonal heterogeneity of calcium distribution in rat hepatocytes: an electron microscopic study with a combined glutaraldehyde-osmium-pyroantimonate technique. Angermüller, S., Juchem, R., Beier, K., Konrad, T., Kusterer, K. J. Histochem. Cytochem. (1994) [Pubmed]
  13. Combined characterization of composite tabular silver halide microcrystals by cryo-EFTEM/EELS and cryo-STEM/EDX techniques. Oleshko, V.P., Gijbels, R.H., Van Daele, A.J., Jacob, W.A., Xu, Y.E., Wang, S.E., Park, I.Y., Kang, T.S. Microsc. Res. Tech. (1998) [Pubmed]
  14. The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation. Merkle, D., Douglas, P., Moorhead, G.B., Leonenko, Z., Yu, Y., Cramb, D., Bazett-Jones, D.P., Lees-Miller, S.P. Biochemistry (2002) [Pubmed]
  15. ERK modulates DNA bending and enhancesome structure by phosphorylating HMG1-boxes 1 and 2 of the RNA polymerase I transcription factor UBF. Stefanovsky, V.Y., Langlois, F., Bazett-Jones, D., Pelletier, G., Moss, T. Biochemistry (2006) [Pubmed]
  16. A nonribosomal landscape in the nucleolus revealed by the stem cell protein nucleostemin. Politz, J.C., Polena, I., Trask, I., Bazett-Jones, D.P., Pederson, T. Mol. Biol. Cell (2005) [Pubmed]
  17. Protein and DNA requirements for the transcription factor IIIA-induced distortion of the 5 S rRNA gene promoter. Brown, M.L., Schroth, G.P., Gottesfeld, J.M., Bazett-Jones, D.P. J. Mol. Biol. (1996) [Pubmed]
  18. Nanoscale precipitation in a maraging steel studied by APFIM. Stiller, K., Hättestrand, M. Microsc. Microanal. (2004) [Pubmed]
  19. Subcellular distribution of titanium in the liver after treatment with the antitumor agent titanocene dichloride. A study using electron spectroscopic imaging. Köpf-Maier, P., Martin, R. Virchows Arch., B, Cell Pathol. (1989) [Pubmed]
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