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Chemical Compound Review

TERBIUM     terbium

Synonyms: terbio, Terbium-159;, AG-G-95708, ACMC-20ajly, CHEBI:33376, ...
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Disease relevance of terbium


High impact information on terbium


Chemical compound and disease context of terbium


Biological context of terbium

  • Energy transfer between terbium (III) and cobalt (II) in thermolysin: a new class of metal--metal distance probes [13].
  • Terbium (Tb3+), an ion of the lanthanide series that has been used as a fluorescent probe for calcium (Ca2+) binding sites in proteins, binds to the proteins in both solubilized and purified human placental insulin receptor preparations [14].
  • Competition between Mg-ATP and Tb-FTP for ATP hydrolysis indicates that terbium-associated nucleotides bind to the catalytic site of the H+-ATPase [15].
  • Comparison of terbium (III) luminescence enhancement in mutants of EF hand calcium binding proteins [16].
  • Changes in the relative occupancy of metal-binding sites in the profile structure of the sarcoplasmic reticulum membrane induced by phosphorylation of the Ca2+ATPase enzyme in the presence of terbium: a time-resolved, resonance x-ray diffraction study [17].

Anatomical context of terbium


Associations of terbium with other chemical compounds


Gene context of terbium


Analytical, diagnostic and therapeutic context of terbium


  1. Direct kinetic evidence for triplet state energy transfer from Escherichia coli alkaline phosphatase tryptophan 109 to bound terbium. Schlyer, B.D., Steel, D.G., Gafni, A. J. Biol. Chem. (1995) [Pubmed]
  2. Terbium-mediated footprinting probes a catalytic conformational switch in the antigenomic hepatitis delta virus ribozyme. Harris, D.A., Tinsley, R.A., Walter, N.G. J. Mol. Biol. (2004) [Pubmed]
  3. Kinetic effects of terbium ions on muscarinic acetylcholine receptors of murine neuroblastoma cells. El-Fakahany, E.E., Pfenning, M., Richelson, E. J. Neurochem. (1984) [Pubmed]
  4. Enhancement of cisplatin cytotoxicity by terbium in cisplatin-resistant MDA/CH human breast cancer cells. Fuller, T.L., Canada, R.G. Cancer Chemother. Pharmacol. (1999) [Pubmed]
  5. Evidence of a calcium-induced structural change in the ATP-binding site of the sarcoplasmic-reticulum Ca2+-ATPase using terbium formycin triphosphate as an analogue of Mg-ATP. Girardet, J.L., Dupont, Y., Lacapere, J.J. Eur. J. Biochem. (1989) [Pubmed]
  6. Ligand and cation binding are dual functions of a discrete segment of the integrin beta 3 subunit: cation displacement is involved in ligand binding. D'Souza, S.E., Haas, T.A., Piotrowicz, R.S., Byers-Ward, V., McGrath, D.E., Soule, H.R., Cierniewski, C., Plow, E.F., Smith, J.W. Cell (1994) [Pubmed]
  7. Engineering a terbium-binding site into an integral membrane protein for luminescence energy transfer. Vázquez-Ibar, J.L., Weinglass, A.B., Kaback, H.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  8. Coordination of the two heads of myosin during muscle contraction. Lidke, D.S., Thomas, D.D. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  9. In situ molecular association of dystrophin with actin revealed by sensitized emission immuno-resonance energy transfer. Root, D.D. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  10. Terbium modulation of single gamma-aminobutyric acid-activated chloride channels in rat dorsal root ganglion neurons. Ma, J.Y., Reuveny, E., Narahashi, T. J. Neurosci. (1994) [Pubmed]
  11. Dual-label time-resolved fluoroimmunoassay for the simultaneous detection of adenovirus and rotavirus in faeces. Siitari, H. J. Virol. Methods (1990) [Pubmed]
  12. Pulmonary toxicity of systemic terbium chloride in mice. Shimada, H., Nagano, M., Funakoshi, T., Kojima, S. Journal of toxicology and environmental health. (1996) [Pubmed]
  13. Energy transfer between terbium (III) and cobalt (II) in thermolysin: a new class of metal--metal distance probes. Horrocks, W.D., Holmquist, B., Vallee, B.L. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  14. Terbium, a fluorescent probe for insulin receptor binding. Evidence for a conformational change in the receptor protein due to insulin binding. Williams, P.F., Turtle, J.R. Diabetes (1984) [Pubmed]
  15. Study of the nucleotide binding site of the yeast Schizosaccharomyces pombe plasma membrane H+-ATPase using formycin triphosphate-terbium complex. Ronjat, M., Lacapere, J.J., Dufour, J.P., Dupont, Y. J. Biol. Chem. (1987) [Pubmed]
  16. Comparison of terbium (III) luminescence enhancement in mutants of EF hand calcium binding proteins. Hogue, C.W., MacManus, J.P., Banville, D., Szabo, A.G. J. Biol. Chem. (1992) [Pubmed]
  17. Changes in the relative occupancy of metal-binding sites in the profile structure of the sarcoplasmic reticulum membrane induced by phosphorylation of the Ca2+ATPase enzyme in the presence of terbium: a time-resolved, resonance x-ray diffraction study. Asturias, F.J., Fischetti, R.F., Blasie, J.K. Biophys. J. (1994) [Pubmed]
  18. Interaction of three second-generation anthracyclines with polynucleotides, RNA, DNA, and nucleosomes. Pearlman, L.F., Chuang, R.Y., Israel, M., Simpkins, H. Cancer Res. (1986) [Pubmed]
  19. Ca2+ binding sites of the ryanodine receptor/Ca2+ release channel of sarcoplasmic reticulum. Low affinity binding site(s) as probed by terbium fluorescence. Hadad, N., Zable, A.C., Abramson, J.J., Shoshan-Barmatz, V. J. Biol. Chem. (1994) [Pubmed]
  20. Location of terbium binding sites on acetylcholine receptor-enriched membranes. Fairclough, R.H., Miake-Lye, R.C., Stroud, R.M., Hodgson, K.O., Doniach, S. J. Mol. Biol. (1986) [Pubmed]
  21. Terbium binding to ribosomes and ribosomal RNA. Barela, T.D., Burchett, S., Kizer, D.E. Biochemistry (1975) [Pubmed]
  22. Calcium binding sites of synaptosomes from insect nervous system as probed by trivalent terbium ions. Breer, H., Jeserich, G. J. Neurochem. (1981) [Pubmed]
  23. Effects of adriamycin on supercoiled DNA and calf thymus nucleosomes studied with fluorescent probes. Simpkins, H., Pearlman, L.F., Thompson, L.M. Cancer Res. (1984) [Pubmed]
  24. Identification of metal-binding sites in rat brain calcium-binding protein. Veenstra, T.D., Gross, M.D., Hunziker, W., Kumar, R. J. Biol. Chem. (1995) [Pubmed]
  25. A functional and degenerate pair of EF hands contains the very high affinity calcium-binding site of calbindin-D28K. Gross, M.D., Gosnell, M., Tsarbopoulos, A., Hunziker, W. J. Biol. Chem. (1993) [Pubmed]
  26. Terbium luminescence in synthetic peptide loops from calcium-binding proteins with different energy donors. MacManus, J.P., Hogue, C.W., Marsden, B.J., Sikorska, M., Szabo, A.G. J. Biol. Chem. (1990) [Pubmed]
  27. Synthesis, relaxometric and photophysical properties of a new pH-responsive MRI contrast agent: the effect of other ligating groups on dissociation of a p-nitrophenolic pendant arm. Woods, M., Kiefer, G.E., Bott, S., Castillo-Muzquiz, A., Eshelbrenner, C., Michaudet, L., McMillan, K., Mudigunda, S.D., Ogrin, D., Tircsó, G., Zhang, S., Zhao, P., Sherry, A.D. J. Am. Chem. Soc. (2004) [Pubmed]
  28. The active site of human paraoxonase (PON1). Josse, D., Lockridge, O., Xie, W., Bartels, C.F., Schopfer, L.M., Masson, P. Journal of applied toxicology : JAT. (2001) [Pubmed]
  29. Copper binding affinity of S100A13, a key component of the FGF-1 nonclassical copper-dependent release complex. Sivaraja, V., Kumar, T.K., Rajalingam, D., Graziani, I., Prudovsky, I., Yu, C. Biophys. J. (2006) [Pubmed]
  30. Time-resolved fluorescence imaging for specific and quantitative immunodetection of human kallikrein 2 and prostate-specific antigen in prostatic tissue sections. Siivola, P., Pettersson, K., Piironen, T., Lövgren, T., Lilja, H., Bjartell, A. Urology (2000) [Pubmed]
  31. Metal ion binding affinities of gastrin and CCK in membrane mimetic environments. Lutz, J., Weyher, E., Moroder, L. J. Pept. Sci. (1995) [Pubmed]
  32. Observations on the binding of lanthanides and calcium to vitamin D-dependent chick intestinal calcium-binding protein. Implications regarding calcium-binding protein function. Gross, M.D., Nelsestuen, G.L., Kumar, R. J. Biol. Chem. (1987) [Pubmed]
  33. Enzymatically amplified time-resolved fluorescence immunoassay with terbium chelates. Christopoulos, T.K., Diamandis, E.P. Anal. Chem. (1992) [Pubmed]
  34. Determination of steroids in urine by micellar HPLC with detection by sensitized terbium fluorescence. Amin, M., Harrington, K., von Wandruszka, R. Anal. Chem. (1993) [Pubmed]
  35. Synthesis of a terbium fluorescent chelate and its application to time-resolved fluoroimmunoassay. Yuan, J., Wang, G., Majima, K., Matsumoto, K. Anal. Chem. (2001) [Pubmed]
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