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Gene Review

CRABP1  -  cellular retinoic acid binding protein 1

Homo sapiens

Synonyms: CRABP, CRABP-I, CRABPI, Cellular retinoic acid-binding protein 1, Cellular retinoic acid-binding protein I, ...
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Disease relevance of CRABP1


High impact information on CRABP1


Chemical compound and disease context of CRABP1


Biological context of CRABP1


Anatomical context of CRABP1


Associations of CRABP1 with chemical compounds

  • BHY cells expressed all of retinoid nuclear receptors (RARalpha, beta, gamma, and RXRalpha) and cytoplasmic retinoic acid binding proteins (CRABP1 and CRABP2) [22].
  • Our data are consistent with a role for CRABP in regulating the amount of RA delivered to the nucleus [18].
  • Sj-FABPc of the blood fluke of humans, Schistosoma japonicum, is a member of the FABP/P2/CRBP/CRABP family of beta-barrel cytosolic fatty-acid-binding and retinoid-binding proteins [23].
  • Analysis of HMQC, HMQC-TOCSY, and 13C-TOCSY-REVINEPT on CRABP-bound (2,3,6,7,8,9,10,11,19-13C)- and (1,4,5,8,9,16, 17,18,19-13C)-all trans-retinoic acid allowed the unambiguous assignment of all labeled protons and their attached 13C resonances [24].
  • The protein is a single polypeptide chain with a molecular mass of 14,600 Da, estimated by sodium dodecyl sulfate (SDS) gel electrophoresis or gel filtration, and has an isoelectric point of 4.78 (apo-CRABP, 4.82) [25].

Physical interactions of CRABP1


Regulatory relationships of CRABP1


Other interactions of CRABP1


Analytical, diagnostic and therapeutic context of CRABP1


  1. Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma. Huang, Y., de la Chapelle, A., Pellegata, N.S. Int. J. Cancer (2003) [Pubmed]
  2. Effects of retinoic acid and gamma-interferon on expression of retinoic acid receptor and cellular retinoic acid-binding protein in breast cancer cells. Widschwendter, M., Daxenbichler, G., Dapunt, O., Marth, C. Cancer Res. (1995) [Pubmed]
  3. Localization of cellular retinoid-binding proteins in human cervical intraepithelial neoplasia and invasive carcinoma. Hillemanns, P., Tannous-Khuri, L., Koulos, J.P., Talmage, D., Wright, T.C. Am. J. Pathol. (1992) [Pubmed]
  4. 9-cis-retinoic acid selectively activates the cellular retinoic acid binding protein-II gene in human neuroblastoma cells. Plum, L.A., Clagett-Dame, M. Arch. Biochem. Biophys. (1995) [Pubmed]
  5. Expression, purification, and binding properties of human cellular retinoic acid-binding protein type I and type II. Fogh, K., Voorhees, J.J., Aström, A. Arch. Biochem. Biophys. (1993) [Pubmed]
  6. Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma. Tanaka, K., Imoto, I., Inoue, J., Kozaki, K., Tsuda, H., Shimada, Y., Aiko, S., Yoshizumi, Y., Iwai, T., Kawano, T., Inazawa, J. Oncogene (2007) [Pubmed]
  7. Overview of current knowledge of metabolism of vitamin A and carotenoids. Goodman, D.S. J. Natl. Cancer Inst. (1984) [Pubmed]
  8. Cellular retinoic acid-binding protein in human lung carcinomas. Clamon, G.H., Nugent, K.M., Rossi, N.P. J. Natl. Cancer Inst. (1981) [Pubmed]
  9. Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance. Carr, A., Samaras, K., Chisholm, D.J., Cooper, D.A. Lancet (1998) [Pubmed]
  10. Retinoic acid receptors and retinoid binding proteins in endometrial adenocarcinoma: differential expression of cellular retinoid binding proteins in endometrioid tumours. Siddiqui, N.A., Thomas, E.J., Dunlop, W., Redfern, C.P. Int. J. Cancer (1995) [Pubmed]
  11. Increasing the intracellular availability of all-trans retinoic acid in neuroblastoma cells. Armstrong, J.L., Ruiz, M., Boddy, A.V., Redfern, C.P., Pearson, A.D., Veal, G.J. Br. J. Cancer (2005) [Pubmed]
  12. Plasma and skin carriers for natural and synthetic retinoids. Siegenthaler, G., Saurat, J.H. Archives of dermatology. (1987) [Pubmed]
  13. Sex difference in cellular retinol- and retinoic acid-binding proteins in human colon adenocarcinomas. Palan, P.R., Duttagupta, C., Romney, S.L. Cancer Lett. (1980) [Pubmed]
  14. Drug interaction of isotretinoin and protease inhibitors: support for the cellular retinoic acid-binding protein-1 theory of lipodystrophy? Padberg, J., Schürmann, D., Grobusch, M., Bergmann, F. AIDS (1999) [Pubmed]
  15. Assignment of the genes for cellular retinoic acid binding protein 1 (CRABP1) and 2 (CRABP2) to human chromosome band 15q24 and 1q21.3, respectively, by in situ hybridization. Flagiello, D., Apiou, F., Gibaud, A., Poupon, M.F., Dutrillaux, B., Malfoy, B. Cytogenet. Cell Genet. (1997) [Pubmed]
  16. The cellular retinoic acid binding protein II is a positive regulator of retinoic acid signaling in breast cancer cells. Jing, Y., Waxman, S., Mira-y-Lopez, R. Cancer Res. (1997) [Pubmed]
  17. Suppression of mammary carcinoma growth by retinoic acid: proapoptotic genes are targets for retinoic acid receptor and cellular retinoic acid-binding protein II signaling. Donato, L.J., Noy, N. Cancer Res. (2005) [Pubmed]
  18. The molecular cloning and expression of two CRABP cDNAs from human skin. Eller, M.S., Oleksiak, M.F., McQuaid, T.J., McAfee, S.G., Gilchrest, B.A. Exp. Cell Res. (1992) [Pubmed]
  19. Fatty acid binding proteins from different tissues show distinct patterns of fatty acid interactions. Richieri, G.V., Ogata, R.T., Zimmerman, A.W., Veerkamp, J.H., Kleinfeld, A.M. Biochemistry (2000) [Pubmed]
  20. Cellular retinoid binding proteins and nuclear retinoic acid receptors in endometrial epithelial cells. Siddiqui, N.A., Loughney, A., Thomas, E.J., Dunlop, W., Redfern, C.P. Hum. Reprod. (1994) [Pubmed]
  21. Regulation of cellular retinoic acid binding protein (CRABP II) during human monocyte differentiation in vitro. Kreutz, M., Fritsche, J., Andreesen, R., Krause, S.W. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  22. Low-dose retinoic acid enhances in vitro invasiveness of human oral squamous-cell-carcinoma cell lines. Uchida, D., Kawamata, H., Nakashiro, K., Omotehara, F., Hino, S., Hoque, M.O., Begum, N.M., Yoshida, H., Sato, M., Fujimori, T. Br. J. Cancer (2001) [Pubmed]
  23. Sj-FABPc fatty-acid-binding protein of the human blood fluke Schistosoma japonicum: structural and functional characterization and unusual solvent exposure of a portal-proximal tryptophan residue. Kennedy, M.W., Scott, J.C., Lo, S., Beauchamp, J., McManus, D.P. Biochem. J. (2000) [Pubmed]
  24. Nuclear magnetic resonance studies demonstrate differences in the interaction of retinoic acid with two highly homologous cellular retinoic acid binding proteins. Norris, A.W., Rong, D., d'Avignon, D.A., Rosenberger, M., Tasaki, K., Li, E. Biochemistry (1995) [Pubmed]
  25. Purification and partial characterization of cellular retinoic acid-binding protein from human placenta. Okuno, M., Kato, M., Moriwaki, H., Kanai, M., Muto, Y. Biochim. Biophys. Acta (1987) [Pubmed]
  26. Presence of cellular retinol and retinoic acid-binding proteins in epidermoid carcinoma of the oral cavity and oropharynx. Ong, D.E., Goodwin, W.J., Jesse, R.H., Griffin, A.C. Cancer (1982) [Pubmed]
  27. CRABP I expression and the mediation of the sensitivity of human tumour cells to retinoic acid and irradiation. Blaese, M.A., Santo-Hoeltje, L., Rodemann, H.P. Int. J. Radiat. Biol. (2003) [Pubmed]
  28. The effect of cellular retinoic acid binding protein-I expression on the CYP26-mediated catabolism of all-trans retinoic acid and cell proliferation in head and neck squamous cell carcinoma. Won, J.Y., Nam, E.C., Yoo, S.J., Kwon, H.J., Um, S.J., Han, H.S., Kim, S.H., Byun, Y., Kim, S.Y. Metab. Clin. Exp. (2004) [Pubmed]
  29. Cellular retinol-binding protein in mucosa, in benign and malignant non-squamous cell tumours of the head and neck. Wahlberg, P., Fex, G., Wennerberg, J., Willén, R. Acta Otolaryngol. (1989) [Pubmed]
  30. Expression of CRABP-I and -II in human epidermal cells. Alteration of relative protein amounts is linked to the state of differentiation. Siegenthaler, G., Tomatis, I., Chatellard-Gruaz, D., Jaconi, S., Eriksson, U., Saurat, J.H. Biochem. J. (1992) [Pubmed]
  31. Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells. Liu, W., Hellman, P., Li, Q., Yu, W.R., Juhlin, C., Nordlinder, H., Rollman, O., Akerström, G., Törmä, H., Melhus, H. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  32. Topical retinoic acid alters the expression of cellular retinoic acid-binding protein-I and cellular retinoic acid-binding protein-II in non-lesional but not lesional psoriatic skin. Karlsson, T., Virtanen, M., Sirsjö, A., Rollman, O., Vahlquist, A., Törmä, H. Exp. Dermatol. (2002) [Pubmed]
  33. Lack of mutations in LMNA, its promoter region, and the cellular retinoic acid binding protein II (CRABP II) in HIV associated lipodystrophy. Behrens, G.M., Genschel, J., Schmidt, R.E., Schmidt, H.H. Eur. J. Med. Res. (2003) [Pubmed]
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