Disease relevance of Galvanic Skin Response

• RESEARCH DESIGN AND METHODS--The age-matched study subjects included 20 non-insulin-dependent diabetes mellitus (NIDDM) patients with autonomic neuropathy (DN) and 10 NIDDM patients without autonomic neuropathy (D), assessed by standard cardiovascular tests and galvanic skin response, and 8 control subjects (C) [1].

High impact information on Galvanic Skin Response

• Experiments performed during sham LBNP and with skin temperature kept constant suggest that the electrodermal response was due to a decrease in skin temperature produced by the LBNP [2].
• Forty-eight undrugged hospital admissions with a present state examination (PSE) diagnosis of schizophrenia were subdivided by the direction of lateral differences in electrodermal response amplitudes to tones [3].
• RESULTS: Galvanic skin response (GSR) and heart rate (HR) were significantly increased within 1 min following 0.2 microg/kg pentagastrin, the GSR increase correlating negatively to the C-peptide increase and positively to ratings on SADS [4].
• METHOD: Because several characteristics of psychophysiological response had been shown to be associated with future increased likelihood of adult antisocial behavior, autonomic arousal as well as electrodermal responses to orienting and aversive stimuli were assessed in 26 boys with ADHD+CD compared with 21 boys with ADHD alone and 21 controls [5].
• Startle magnitude facilitation and electrodermal responses were larger during a CS that preceded the US than during a CS that was presented alone regardless of lead stimulus modality [6].

Anatomical context of Galvanic Skin Response

• Clonidine inhibits electrodermal responses by an action on the spinal cord [7].
• Administration of ketanserin (0.03-3.0 mg/kg i.v.) caused a dose-related depression of sympathetic-cholinergic electrodermal responses evoked by electrical stimulation of the hypothalamus in pentobarbital anesthetized cats [8].
• Intravenous administration of the alpha 1-adrenoceptor antagonist, prazosin (3-300 micrograms/kg), produced a depression of sympathetic-cholinergic electrodermal responses evoked by electrical stimulation of the posterior hypothalamus in pentobarbital anesthetized cats [9].
• The results from all three psychophysiological measures together suggest that the neural circuits affecting P300 amplitude and electrodermal response modulation are different and that poor electrodermal response modulation may reflect an inhibitory control deficit mediated by the frontal lobes [10].

Associations of Galvanic Skin Response with chemical compounds

• The action of chlorpromazine on the electrodermal response in the cat [11].
• Epinephrine inhibition of the electrodermal response in the cat [12].
• Experiments were designed to determine the neural site of action for clonidine inhibition of sympathetic-cholinergic electrodermal responses (EDR) in anesthetized cats [7].
• Pretreatment with the alpha 2-adrenoceptor antagonists yohimbine (0.5 mg/kg) or idazoxan (0.1 mg/kg) significantly blocked the depressant effects of prazosin but had no effect on hypothalamic evoked electrodermal responses when given alone [9].
• The effects of clonidine and five analogs of clonidine were tested with regard to their ability to depress centrally and peripherally evoked electrodermal responses (EDR) in control cats, as well as in animals pretreated with yohimbine hydrochloride [13].

Gene context of Galvanic Skin Response

• RESULTS: Abused children had smaller changes in pulse height in the first two stimulus conditions presented ("No Signal" and "Math"), but their electrodermal responses were lower throughout all stimulus conditions [14].
• Eighteen psychopathic individuals and 18 incarcerated control individuals, identified using the Revised Psychopathy Checklist (Hare, 1991, The Hare Psychopathy Checklist-Revised, Toronto: Multi-Health Systems), were shown slides of these three types of stimuli, and their electrodermal responses were recorded [15].
• Clinical efficacy of galvanic skin response biofeedback training in reducing seizures in adult epilepsy: a preliminary randomized controlled study [16].
• Experimentation began as a test of the proposition that electrodermal response to a random signal (or CSR) would lie between the response to a reinforced or excitatory stimulus (CS+) and that to a nonreinforced or inhibitory stimulus (CS- or CSI) [17].

Analytical, diagnostic and therapeutic context of Galvanic Skin Response

• Prazosin also depressed the amplitude of electrodermal responses evoked by electrical stimulation of the cervical spinal cord in spinalized cats [9].

References