Gene Review:
IFNGR1 - interferon gamma receptor 1
Homo sapiens
Synonyms:
CD119, CDw119, IFN-gamma receptor 1, IFN-gamma-R1, IFNGR, ...
Kotenko,
Izotova,
Mirochnitchenko,
Esterova,
Dickensheets,
Donnelly,
Pestka,
Subramaniam,
Johnson,
Matsuda,
Ebihara,
Kumagai,
Fukuda,
Ebe,
Hirano,
Sotozono,
Tei,
Hasegawa,
Shimizu,
Tamari,
Namba,
Ohno,
Mizuki,
Ikezawa,
Shirakawa,
Hamuro,
Kinoshita,
Koch,
Awomoyi,
Usen,
Jallow,
Richardson,
Hull,
Pinder,
Newport,
Kwiatkowski,
Johnson,
Ahmed,
Costa-Pereira,
Hermanns,
Is'harc,
Williams,
Watling,
Arulampalam,
Newman,
Heinrich,
Kerr,
- Identification of a phorbol ester-responsive element in the interferon-gamma receptor 1 chain gene. Sakamoto, S., Taniguchi, T. J. Biol. Chem. (2001)
- IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria. Koch, O., Awomoyi, A., Usen, S., Jallow, M., Richardson, A., Hull, J., Pinder, M., Newport, M., Kwiatkowski, D. J. Infect. Dis. (2002)
- Missense mutations of the interleukin-12 receptor beta 1(IL12RB1) and interferon-gamma receptor 1 (IFNGR1) genes are not associated with susceptibility to lepromatous leprosy in Korea. Lee, S.B., Kim, B.C., Jin, S.H., Park, Y.G., Kim, S.K., Kang, T.J., Chae, G.T. Immunogenetics (2003)
- Polymorphisms in an interferon-gamma receptor-1 gene marker and susceptibility to periodontitis. Fraser, D.A., Loos, B.G., Boman, U., van Winkelhoff, A.J., van der Velden, U., Schenck, K., Dembic, Z. Acta Odontol. Scand. (2003)
- Genetic polymorphisms in the promoter of the interferon gamma receptor 1 gene are associated with atopic cataracts. Matsuda, A., Ebihara, N., Kumagai, N., Fukuda, K., Ebe, K., Hirano, K., Sotozono, C., Tei, M., Hasegawa, K., Shimizu, M., Tamari, M., Namba, K., Ohno, S., Mizuki, N., Ikezawa, Z., Shirakawa, T., Hamuro, J., Kinoshita, S. Invest. Ophthalmol. Vis. Sci. (2007)
- A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection. Newport, M.J., Huxley, C.M., Huston, S., Hawrylowicz, C.M., Oostra, B.A., Williamson, R., Levin, M. N. Engl. J. Med. (1996)
- MyD88-mediated stabilization of interferon-gamma-induced cytokine and chemokine mRNA. Sun, D., Ding, A. Nat. Immunol. (2006)
- Soluble cytokine receptors are present in normal human urine. Novick, D., Engelmann, H., Wallach, D., Rubinstein, M. J. Exp. Med. (1989)
- Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guérin infection and a sibling with clinical tuberculosis. Jouanguy, E., Lamhamedi-Cherradi, S., Altare, F., Fondanèche, M.C., Tuerlinckx, D., Blanche, S., Emile, J.F., Gaillard, J.L., Schreiber, R., Levin, M., Fischer, A., Hivroz, C., Casanova, J.L. J. Clin. Invest. (1997)
- Indole-3-carbinol stimulates transcription of the interferon gamma receptor 1 gene and augments interferon responsiveness in human breast cancer cells. Chatterji, U., Riby, J.E., Taniguchi, T., Bjeldanes, E.L., Bjeldanes, L.F., Firestone, G.L. Carcinogenesis (2004)
- Phosphoric acid entrapment leads to apparent protein heterogeneity. Fountoulakis, M., Vilbois, F., Oesterhelt, G., Vetter, W. Biotechnology (N.Y.) (1995)
- Genomewide linkage analysis identifies polymorphism in the human interferon-gamma receptor affecting Helicobacter pylori infection. Thye, T., Burchard, G.D., Nilius, M., Müller-Myhsok, B., Horstmann, R.D. Am. J. Hum. Genet. (2003)
- Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. Kotenko, S.V., Izotova, L.S., Mirochnitchenko, O.V., Esterova, E., Dickensheets, H., Donnelly, R.P., Pestka, S. J. Immunol. (2001)
- The Stat1 binding motif of the interferon-gamma receptor is sufficient to mediate Stat5 activation and its repression by SOCS3. Woldman, I., Varinou, L., Ramsauer, K., Rapp, B., Decker, T. J. Biol. Chem. (2001)
- Signaling through a mutant IFN-gamma receptor. Costa-Pereira, A.P., Hermanns, H.M., Is'harc, H., Williams, T.M., Watling, D., Arulampalam, V., Newman, S.J., Heinrich, P.C., Kerr, I.M. J. Immunol. (2005)
- T Cell-Dependent Activation of Dendritic Cells Requires IL-12 and IFN-{gamma} Signaling in T Cells. Miro, F., Nobile, C., Blanchard, N., Lind, M., Filipe-Santos, O., Fieschi, C., Chapgier, A., Vogt, G., de Beaucoudrey, L., Kumararatne, D.S., Le Deist, F., Casanova, J.L., Amigorena, S., Hivroz, C. J. Immunol. (2006)
- Lipid microdomains are required sites for the selective endocytosis and nuclear translocation of IFN-gamma, its receptor chain IFN-gamma receptor-1, and the phosphorylation and nuclear translocation of STAT1alpha. Subramaniam, P.S., Johnson, H.M. J. Immunol. (2002)
- A novel gene of beta chain of the IFN-gamma receptor of Huiyang chicken: cloning, distribution, and CD assay. Han, C.L., Zhang, W., Dong, H.T., Han, X., Wang, M. J. Interferon Cytokine Res. (2006)
- Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor. Igarashi, K., Garotta, G., Ozmen, L., Ziemiecki, A., Wilks, A.F., Harpur, A.G., Larner, A.C., Finbloom, D.S. J. Biol. Chem. (1994)
- TGF-beta1 suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation. Takaki, H., Minoda, Y., Koga, K., Takaesu, G., Yoshimura, A., Kobayashi, T. Genes Cells (2006)
- Antiblastic chemotherapy drugs up-modulate interferon-gamma receptor expression on human malignant T cells. Novelli, F., Allione, A., Bernabei, P., Rigamonti, L., Forni, G. Cancer Detect. Prev. (1997)
- Prostaglandin E2 selectively increases interferon gamma receptor expression on human CD8+ lymphocytes. elMasry, M.N., Rich, R.R. J. Clin. Invest. (1989)
- The extracellular domain of the human interferon gamma receptor interacts with a species-specific signal transducer. Gibbs, V.C., Williams, S.R., Gray, P.W., Schreiber, R.D., Pennica, D., Rice, G., Goeddel, D.V. Mol. Cell. Biol. (1991)
- A bivalent immunoadhesin of the human interferon-gamma receptor is an effective inhibitor of IFN-gamma activity. Moosmayer, D., Gerlach, E., Hauff, R., Becker, P., Brocks, B., Pfizenmaier, K. J. Interferon Cytokine Res. (1995)
- The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors. Sakatsume, M., Igarashi, K., Winestock, K.D., Garotta, G., Larner, A.C., Finbloom, D.S. J. Biol. Chem. (1995)
- Tumor necrosis factor-alpha and IL-6 up-regulate IFN-gamma receptor gene expression in human monocytic THP-1 cells by transcriptional and post-transcriptional mechanisms. Sanceau, J., Merlin, G., Wietzerbin, J. J. Immunol. (1992)
- Abnormal levels of interferon-gamma receptors in active multiple sclerosis are normalized by IFN-beta therapy: implications for control of apoptosis. Ahn, J., Feng, X., Patel, N., Dhawan, N., Reder, A.T. Front. Biosci. (2004)
- Altered synthesis of interferon-gamma and expression of interferon-gamma receptor by peripheral blood mononuclear cells from patients with IgA nephropathy and non-IgA proliferative glomerulonephritis. Yano, N., Endoh, M., Naka, R., Takemura, F., Nomoto, Y., Sakai, H. J. Clin. Immunol. (1996)
- Association of IFN-gamma and IFN regulatory factor 1 polymorphisms with childhood atopic asthma. Nakao, F., Ihara, K., Kusuhara, K., Sasaki, Y., Kinukawa, N., Takabayashi, A., Nishima, S., Hara, T. J. Allergy Clin. Immunol. (2001)
- Severe Mycobacterium bovis BCG infections in a large series of novel IL-12 receptor beta1 deficient patients and evidence for the existence of partial IL-12 receptor beta1 deficiency. Lichtenauer-Kaligis, E.G., de Boer, T., Verreck, F.A., van Voorden, S., Hoeve, M.A., van de Vosse, E., Ersoy, F., Tezcan, I., van Dissel, J.T., Sanal, O., Ottenhoff, T.H. Eur. J. Immunol. (2003)
- Human interferon gamma receptor 1 (IFNGR1) gene maps to chromosome region 6q23-6q24. Le Coniat, M., Alcaide-Loridan, C., Fellous, M., Berger, R. Hum. Genet. (1989)
- Interferon-gamma and interferon-gamma receptor 1 and 2 gene polymorphisms and restenosis following coronary stenting. Tiroch, K., von Beckerath, N., Koch, W., Lengdobler, J., Joost, A., Schömig, A., Kastrati, A. Atherosclerosis (2005)
- Gamma interferon signaling: insights to development of interferon mimetics. Johnson, H.M., Ahmed, C.M. Cell. Mol. Biol. (Noisy-le-grand) (2006)