Disease relevance of Bird Fancier's Lung

• METHODS: This report is on 36 cases of chronic HP, including 10 patients with summer-type HP, 5 patients with home-related HP, 7 patients with bird fancier's lung, 5 patients with isocyanate-induced HP, 4 patients with farmer's lung, and 5 patients with other types of chronic HP [1].
• We have studied the antibody response to fungal antigens in sera and bronchoalveolar lavage (BAL) fluids from patients with summer type hypersensitivity pneumonitis, bird fancier's lung, interstitial pneumonia associated with collagen vascular disease (INT-PNE), and from normal volunteers [2].

High impact information on Bird Fancier's Lung

• Sixteen patients with bird-fancier's lung were screened for evidence of coeliac disease by assessing their clinical features, red-bloodcell or serum folate levels, and serum for reticulin antibodies [3].
• Genotyping for the -308 TNF-alpha promoter polymorphism and the TNF-beta intron 1 gene polymorphism was performed in 20 patients with farmer's lung, 25 patients with pigeon breeder's lung, and 216 controls [4].
• The ratio of CD4 to CD8 in BAL lymphocytes was lowest in isocyanate-induced HP (mean 0.22) and tended to be high in farmer's lung and bird fancier's lung [1].
• Analysis of KL-6 and SP-D as disease markers in bird fancier's lung [5].
• Sera from all 32 symptomatic patients with pigeon breeders' lung demonstrated an IgG3 reaction with mucin, but only three sera showed reactivity against IgA and this was very weak [6].

Chemical compound and disease context of Bird Fancier's Lung

• It is unknown to what extent pigeon-breeder's lung caused by nondomestic birds remains undetected and misdiagnosed as difficult or steroid-resistant asthma [7].
• The present study has shown that: (1) All patients with bird fancier's lung (BFL) demonstrated either a restrictive pattern or a reduced diffusing capacity for carbon monoxide (DLco), or both; one BFL patient showed deterioration in %VC and %DLco after avoidance of direct exposure [8].
• Four patients with pigeon breeder's lung and positive lymphocyte transformation tests to pigeon antigen were given 250 mg hydrocortisone intravenously, after which the test was repeated at 6, 24, and 30 hr [9].

Anatomical context of Bird Fancier's Lung

• Sera from all symptomatics with pigeon breeders' lung and many non-symptomatic pigeon breeders react specifically with the pigeon antigens and in particular pigeon intestinal secretions and isolated pigeon intestinal mucin and IgA [6].

Gene context of Bird Fancier's Lung

• Further IgG3 subclass reactivity specific to pigeon mucin is strongly associated with sera from patients with the active pigeon breeders' lung disease [6].
• Pigeon breeders' lung: pigeon intestinal mucin, an antigen distinct from pigeon IgA [10].
• Pigeon breeders' lung; IgG subclasses to pigeon intestinal mucin and IgA antigens [6].

Analytical, diagnostic and therapeutic context of Bird Fancier's Lung

• To assess its value as a screen for avian antibodies, indirect immunofluorescence against avian intestinal tissue has been to test sera from thirty-nine patients with documented bird-fancier's lung disease, thirty-eight asymptomatic bird-fanciers and 257 controls without known avian contact [11].

References