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MeSH Review

Farmer's Lung

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Disease relevance of Farmer's Lung


High impact information on Farmer's Lung

  • TNF bioactivity was measured after hay dust challenge in eight patients with farmer's lung (Group A) and in 12 healthy, sensitized (antibody-positive) controls (Group B) [5].
  • Pulmonary glutathione levels in acute episodes of Farmer's lung [6].
  • In the present study, we measured the concentrations of elafin, a newly described, low-molecular-weight serine proteinase inhibitor, SLPI, and alpha1(PI) in BAL fluids from eight healthy subjects, 13 asymptomatic farmers, seven farmers with active farmer's lung (FL), and seven farmers with previous (Ex) FL [7].
  • In farmer's lung, the CD4/CD8 ratio in smokers was 6.2 +/- 1.9 (N = 6) in contrast with 3.4 +/- 0.7 for nonsmokers (N = 16) (p less than 0.05) [8].
  • Sera from other disease groups including sera from 13 patients with farmer's lung, 16 with tuberculosis, and 10 individuals with positive prick test to either A. fumigatus or Alternaria alternata were also tested by both types of assay [9].

Chemical compound and disease context of Farmer's Lung


Anatomical context of Farmer's Lung


Gene context of Farmer's Lung

  • Role of interleukin-2 in the development and persistence of lymphocytic alveolitis in farmer's lung [17].
  • Serologically detectable HLA-A, B, and C loci antigens in farmer's lung disease [18].
  • However, sera from farmer's lung patients showed cross-reactivity against antigens from different species [19].
  • There was a mild but significant negative correlation between LYS and farm size in the farmers' lung subjects assessed in winter [20].
  • RESULTS: Patients with acute farmer's lung had significantly higher levels of SP-A than asymptomatic farmers and normal controls (p = 0.005) with mean (SE) values of 1.43 (0.29) micrograms/ml, 0.62 (0.09) microgram/ml, and 0.68 (0.11) microgram/ml, respectively [21].

Analytical, diagnostic and therapeutic context of Farmer's Lung


  1. Bronchial hyperreactivity to methacholine in farmers' lung disease. Freedman, P.M., Ault, B. J. Allergy Clin. Immunol. (1981) [Pubmed]
  2. Dynamic role of hyaluronan (HYA) in connective tissue activation and inflammation. Gerdin, B., Hällgren, R. J. Intern. Med. (1997) [Pubmed]
  3. The frequency of precipitins to trichloroacetic acid-extractable antigens from thermophilic actinomycetes in farmer's lung patients and asymptomatic farmers. Roberts, R.C., Zais, D.P., Emanuel, D.A. Am. Rev. Respir. Dis. (1976) [Pubmed]
  4. Prevalence and incidence of chronic bronchitis and farmer's lung with respect to age, sex, atopy, and smoking. Terho, E.O., Husman, K., Vohlonen, I. European journal of respiratory diseases. Supplement. (1987) [Pubmed]
  5. Tumor necrosis factor-alpha -308 promoter gene polymorphism and increased tumor necrosis factor serum bioactivity in farmer's lung patients. Schaaf, B.M., Seitzer, U., Pravica, V., Aries, S.P., Zabel, P. Am. J. Respir. Crit. Care Med. (2001) [Pubmed]
  6. Pulmonary glutathione levels in acute episodes of Farmer's lung. Behr, J., Degenkolb, B., Beinert, T., Krombach, F., Vogelmeier, C. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  7. Elafin/elastase-specific inhibitor in bronchoalveolar lavage of normal subjects and farmer's lung. Tremblay, G.M., Sallenave, J.M., Israél-Assayag, E., Cormier, Y., Gauldie, J. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  8. Difference in the phenotypes of bronchoalveolar lavage lymphocytes in patients with summer-type hypersensitivity pneumonitis, farmer's lung, ventilation pneumonitis, and bird fancier's lung: report of a nationwide epidemiologic study in Japan. Ando, M., Konishi, K., Yoneda, R., Tamura, M. J. Allergy Clin. Immunol. (1991) [Pubmed]
  9. Diagnostic specificity of a sandwich ELISA for Aspergillus-related diseases. Harvey, C., Shaw, R.J., Longbottom, J.L. J. Allergy Clin. Immunol. (1987) [Pubmed]
  10. Angiotensin-converting enzyme in farmer's lung. Tewksbury, D.A., Marx, J.J., Roberts, R.C., Emanuel, D.A. Chest (1981) [Pubmed]
  11. Mast cell and histamine involvement in farmer's lung disease. Miadonna, A., Pesci, A., Tedeschi, A., Bertorelli, G., Arquati, M., Olivieri, D. Chest (1994) [Pubmed]
  12. Hyaluronic acid (hyaluronan) in BAL fluid distinguishes farmers with allergic alveolitis from farmers with asymptomatic alveolitis. Larsson, K., Eklund, A., Malmberg, P., Bjermer, L., Lundgren, R., Belin, L. Chest (1992) [Pubmed]
  13. Does disodium cromoglycate prevent exacerbation of farmer's lung? Mönkäre, S., Haahtela, T., Vilkka, V., Jokela, H. Allergy (1982) [Pubmed]
  14. Occupational hypersensitivity pneumonitis in Japan: data on a nationwide epidemiological study. Yoshida, K., Suga, M., Nishiura, Y., Arima, K., Yoneda, R., Tamura, M., Ando, M. Occupational and environmental medicine. (1995) [Pubmed]
  15. Fibrogenic activities in bronchoalveolar lavage fluid of farmer's lung. Cormier, Y., Laviolette, M., Cantin, A., Tremblay, G.M., Bégin, R. Chest (1993) [Pubmed]
  16. Antigenic determinants on B cells of farmer's lung patients. Koskimies, S., Terho, E.O., Heinonen, O.P., Mäntyjärvi, R. European journal of respiratory diseases. (1982) [Pubmed]
  17. Role of interleukin-2 in the development and persistence of lymphocytic alveolitis in farmer's lung. Dakhama, A., Israel-Assayag, E., Cormier, Y. Eur. Respir. J. (1998) [Pubmed]
  18. Serologically detectable HLA-A, B, and C loci antigens in farmer's lung disease. Flaherty, D.K., Braun, S.R., Marx, J.J., Blank, J.L., Emanuel, D.A., Rankin, J. Am. Rev. Respir. Dis. (1980) [Pubmed]
  19. Immunologic cross-reactions among thermophilic actinomycetes associated with hypersensitivity pneumonitis. Kurup, V.P., Barboriak, J.J., Fink, J.N., Scribner, G. J. Allergy Clin. Immunol. (1976) [Pubmed]
  20. Raised enzyme markers of chronic inflammation in asymptomatic farmers' lung. Turton, C.W., Firth, G., Grundy, E., Rigden, B.G., Smyth, J.T., Turner-Warwick, M. Thorax (1981) [Pubmed]
  21. Effect of contact avoidance or treatment with oral prednisolone on bronchoalveolar lavage surfactant protein A levels in subjects with farmer's lung. Cormier, Y., Israël-Assayag, E., Desmeules, M., Lesur, O. Thorax (1996) [Pubmed]
  22. Characterization of Micropolyspora faeni antigens. Kurup, V.P., Ting, E.Y., Fink, J.N., Calvanico, N.J. Infect. Immun. (1981) [Pubmed]
  23. Comparison of Aspergillus fumigatus and Aspergillus umbrosus antigens in serological tests of farmer's lung. Ojanen, T.H., Terho, E.O., Mäntyjärvi, R.A. Allergy (1982) [Pubmed]
  24. Antibodies of different immunoglobulin classes against antigens causing farmer's lung. Patterson, R., Roberts, M., Roberts, R.C., Emanuel, D.A., Fink, J.N. Am. Rev. Respir. Dis. (1976) [Pubmed]
  25. Microbiological and serological studies of farmers' lung in Finland. Terho, E.O., Lacey, J. Clin. Allergy (1979) [Pubmed]
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