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Chemical Compound Review

Amipaque     3-acetamido-5-(ethanoyl- methyl-amino)-2,4...

Synonyms: Amipak, metrizamide, Amipaque (TN), AG-F-03228, BSPBio_000566, ...
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Disease relevance of metrizamide


Psychiatry related information on metrizamide


High impact information on metrizamide

  • A computed tomographic metrizamide cisternogram showed a pedunculated mass below the tuber cinereum; the mass was resected [11].
  • Normodense human peripheral blood eosinophils were isolated under sterile conditions from the 22/23 and 23/24% interfaces and the cell pellet of metrizamide gradients [12].
  • Eosinophils cultured for 7 d localized on density gradient sedimentation at the medium/18, 18/20, and 20/21 interfaces of metrizamide gradients, indicating a change to the hypodense phenotype from their original normodense condition [12].
  • First, bone marrow cells are centrifuged in a discontinuous metrizamide gradient and simultaneously labeled with wheat germ agglutinin-fluorescein isothiocyanate (WGA-FITC) [13].
  • Further evidence for an alpha granule localization of PADGEM protein was provided by nitrogen cavitation of resting platelets followed by metrizamide density gradient centrifugation; PADGEM protein codistributed with platelet factor 4 [14].

Chemical compound and disease context of metrizamide


Biological context of metrizamide


Anatomical context of metrizamide


Associations of metrizamide with other chemical compounds


Gene context of metrizamide


Analytical, diagnostic and therapeutic context of metrizamide

  • Prolonged delirium after metrizamide myelography [37].
  • Two distinct "heavy" and "light" crude PO fractions were prepared by differential pelleting from normal and regenerating liver, and highly purified PO were subsequently isolated by density-dependent metrizamide gradient centrifugation according to Völkl and Fahimi (1985. Eur. J. Biochem. 149:257-265) [38].
  • 60: 604-617), was subfractionated by isopycnic centrifugation in a metrizamide gradient and the distribution of several marker enzymes was established [24].
  • Subcellular fractionation studies utilizing Percoll and metrizamide gradient centrifugation in addition to molecular exclusion chromatography suggest that the accumulated AChR reside in a compartment with lysosomal characteristics [39].
  • Previous reports may have underestimated the frequency of EEG changes after metrizamide since these may require 24 to 48 hours to develop [40].


  1. Asterixis after metrizamide myelography. Vincent, F.M. JAMA (1980) [Pubmed]
  2. The primary empty sella syndrome. Diagnosis with metrizamide cisternography. Young, W.F., Ospina, L.F., Wesolowski, D., Touma, A. JAMA (1981) [Pubmed]
  3. Nonconvulsive status epilepticus following metrizamide myelogram. Levin, R., Lee, S.I. Ann. Neurol. (1985) [Pubmed]
  4. Epilepsia partialis continua following metrizamide cisternography. Shiozawa, Z., Sasaki, H., Ozaki, Y., Nakanishi, T., Huang, Y.P. Ann. Neurol. (1981) [Pubmed]
  5. Transient areflexia and quadriplegia following metrizamide myelography. Peroutka, S.J., Ullrich, C.G., Fisher, R.S., Suss, R.A., Brooks, B.R. Ann. Neurol. (1982) [Pubmed]
  6. Asterixis and encephalopathy following metrizamide myelography: investigations into possible mechanisms and review of the literature. Bertoni, J.M., Schwartzman, R.J., Van Horn, G., Partin, J. Ann. Neurol. (1981) [Pubmed]
  7. Manic syndrome after metrizamide myelography. Kwentus, J.A., Silverman, J.J., Sprague, M. The American journal of psychiatry. (1984) [Pubmed]
  8. Metrizamide inhibits human brain hexokinase. Bertoni, J.M. Neurology (1982) [Pubmed]
  9. Formed visual hallucinations after metrizamide myelography. Bachman, D.M. Am. J. Ophthalmol. (1984) [Pubmed]
  10. Organic mental disorder associated with metrizamide. Penn, J.R., Mackenzie, T.B. Psychosomatics. (1983) [Pubmed]
  11. Treatment of sexual precocity by removal of a luteinizing hormone-releasing hormone secreting hamartoma. Price, R.A., Lee, P.A., Albright, A.L., Ronnekleiv, O.K., Gutai, J.P. JAMA (1984) [Pubmed]
  12. Regulation of human eosinophil viability, density, and function by granulocyte/macrophage colony-stimulating factor in the presence of 3T3 fibroblasts. Owen, W.F., Rothenberg, M.E., Silberstein, D.S., Gasson, J.C., Stevens, R.L., Austen, K.F., Soberman, R.J. J. Exp. Med. (1987) [Pubmed]
  13. Isolation of murine pluripotent hemopoietic stem cells. Visser, J.W., Bauman, J.G., Mulder, A.H., Eliason, J.F., de Leeuw, A.M. J. Exp. Med. (1984) [Pubmed]
  14. A platelet alpha granule membrane protein that is associated with the plasma membrane after activation. Characterization and subcellular localization of platelet activation-dependent granule-external membrane protein. Berman, C.L., Yeo, E.L., Wencel-Drake, J.D., Furie, B.C., Ginsberg, M.H., Furie, B. J. Clin. Invest. (1986) [Pubmed]
  15. Nonionic dimer: development and initial testing of an intrathecal contrast agent. Sovak, M., Ranganathan, R., Speck, U. Radiology. (1982) [Pubmed]
  16. Postphlebographic thrombosis: a double-blind study with methylglucamine metrizoate and metrizamide. Laerum, F., Holm, H.A. Radiology. (1981) [Pubmed]
  17. Full and empty particles of hepatitis B virus in hepatocytes from patients with HBsAg-positive chronic active hepatitis. Sakamoto, Y., Yamada, G., Mizuno, M., Nishihara, T., Kinoyama, S., Kobayashi, T., Takahashi, T., Nagashima, H. Lab. Invest. (1983) [Pubmed]
  18. Intrathecal toxicity of iohexol vs. metrizamide. Survey and current state. Haughton, V.M. Investigative radiology. (1985) [Pubmed]
  19. Isolation of autophagic vacuoles from rat liver: morphological and biochemical characterization. Marzella, L., Ahlberg, J., Glaumann, H. J. Cell Biol. (1982) [Pubmed]
  20. Fractionation and initial characterization of the kinetochore from mammalian metaphase chromosomes. Valdivia, M.M., Brinkley, B.R. J. Cell Biol. (1985) [Pubmed]
  21. Regional myocardial hemodynamic and metabolic effects of ionic and nonionic contrast media in normal and ischemic states. Gerber, K.H., Higgins, C.B., Yuh, Y.S., Koziol, J.A. Circulation (1982) [Pubmed]
  22. Interstitial cell heterogeneity in rat testes. II. Purification of cells by Percoll and metrizamide gradient centrifugation with preferential localization of gonadotropin binding sites in light cell fraction and hormone-induced steroidogenesis in heavier cell fraction. Bhalla, V.K., Flasch, M.V., Browne, E.S., Sohal, G.S., Sharawy, M.M. J. Biol. Chem. (1987) [Pubmed]
  23. Morphological characterization of Kupffer and endothelial cells of rat liver isolated by counterflow elutriation. Zahlten, R.N., Hagler, H.K., Nejtek, M.E., Day, C.J. Gastroenterology (1978) [Pubmed]
  24. Isolation of rat liver lysosomes by isopycnic centrifugation in a metrizamide gradient. Wattiaux, R., Wattiaux-De Coninck, S., Ronveaux-dupal, M.F., Dubois, F. J. Cell Biol. (1978) [Pubmed]
  25. Calcium transport of Plasmodium chabaudi-infected erythrocytes. Tanabe, K., Mikkelsen, R.B., Wallach, D.F. J. Cell Biol. (1982) [Pubmed]
  26. Isolation of the intercellular glycoproteins of desmosomes. Gorbsky, G., Steinberg, M.S. J. Cell Biol. (1981) [Pubmed]
  27. Studies on the mechanisms of autophagy: maturation of the autophagic vacuole. Dunn, W.A. J. Cell Biol. (1990) [Pubmed]
  28. Stage-specific synthesis of proteins complexed to ribonucleoprotein particles and ribosomes in zoospores of Blastocladiella emersonii. Jaworski, A.J., Stumhofer, P. Mol. Cell. Biol. (1981) [Pubmed]
  29. Parenchymal and nonparenchymal uptake of technetium-99m, indium-111, and iodine-125 low-density lipoprotein in the normal and estradiol-stimulated rat liver: tracer validation for quantitative low-density lipoprotein scintigraphy. Leitha, T., Staudenherz, A., Hermann, M., Hüttinger, M., Gmeiner, B. Hepatology (1995) [Pubmed]
  30. Luteinizing hormone receptors and gonadotropic activation of purified rat Leydig cells. Dehejia, A., Nozu, K., Catt, K.J., Dufau, M.L. J. Biol. Chem. (1982) [Pubmed]
  31. Metrizamide density gradients of sea urchin chromatin: fractions rich and poor in nascent DNA. Levy, A., Jakob, K.M., Moav, B. Nucleic Acids Res. (1975) [Pubmed]
  32. Interaction of a DNA-binding protein, the gene product of D5 of bacteriophage T5, with double-stranded DNA. Analysis by metrizamide gradient centrifugation. Fujimura, R.K., Roop, B.C. J. Biol. Chem. (1982) [Pubmed]
  33. Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. Zhou, L.J., Tedder, T.F. J. Immunol. (1995) [Pubmed]
  34. A novel bulk-culture method for generating mature dendritic cells from mouse bone marrow cells. Son, Y.I., Egawa, S., Tatsumi, T., Redlinger, R.E., Kalinski, P., Kanto, T. J. Immunol. Methods (2002) [Pubmed]
  35. Isolation of human blood dendritic cells by discontinuous Nycodenz gradient centrifugation. McLellan, A.D., Starling, G.C., Hart, D.N. J. Immunol. Methods (1995) [Pubmed]
  36. Identification of thyrotropin-releasing hormone receptor in the rat testis. Satoh, T., Feng, P., Kim, U.J., Wilber, J.F. Neuropeptides (1994) [Pubmed]
  37. Prolonged delirium after metrizamide myelography. Elliott, R.L., Wild, J.H., Snow, W.T. JAMA (1984) [Pubmed]
  38. Biogenesis of peroxisomes: isolation and characterization of two distinct peroxisomal populations from normal and regenerating rat liver. Lüers, G., Hashimoto, T., Fahimi, H.D., Völkl, A. J. Cell Biol. (1993) [Pubmed]
  39. Degradation of acetylcholine receptors in muscle cells: effect of leupeptin on turnover rate, intracellular pool sizes, and receptor properties. Hyman, C., Froehner, S.C. J. Cell Biol. (1983) [Pubmed]
  40. The effect of metrizamide on the electroencephalogram: a prospective study in 61 patients. Ropper, A.H., Chiappa, K.H., Young, R.R. Ann. Neurol. (1979) [Pubmed]
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