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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Inspiratory Capacity

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Disease relevance of Inspiratory Capacity


High impact information on Inspiratory Capacity

  • We measured the change in inspiratory capacity (Delta IC) during exercise to reflect changes in DH [2].
  • Salbutamol induced an improvement of 0.16 +/- 0.02 L (mean +/- SD) in FEV(1), 0.36 +/- 0.04 L in forced inspiratory volume in one second (FIV(1)), 0.30 +/- 0.04 L in inspiratory capacity (IC), and -0.34 +/- 0.07 L in intrathoracic gas volume; the mean VAS score was 36.4 +/- 3 [3].
  • In response to IB (n = 58): FEV(1), FVC, and inspiratory capacity (IC) increased by 7 +/- 1%pred, 10 +/- 1%pred, and 14 +/- 2%pred, respectively (p < 0.001), with no change in the FEV(1)/FVC ratio [4].
  • The inspiratory capacity (IC) maneuver is increasingly used to monitor exercise-induced dynamic hyperinflation in patients with COPD [5].
  • Under fresh (i.e., nonfatigue) conditions, aminophylline significantly increased Pdi,T at lung volumes above 75% of the inspiratory capacity (IC) [6].

Biological context of Inspiratory Capacity


Anatomical context of Inspiratory Capacity


Associations of Inspiratory Capacity with chemical compounds

  • Compared with placebo, albuterol produced an increase in inspiratory capacity (1.87 +/- 0. 71 to 2.26 +/- 0.74 L, p = 0.002), which accounted for the increases in maximal and twitch transdiaphragmatic pressures [13].
  • For secondary end points, patients receiving salmeterol had significant improvement in lung hyperinflation measured by inspiratory capacity which was evident at 4 weeks and maintained over 12 months (p = 0.035), and a significant improvement in health status measured by the St George's Respiratory Questionnaire at 12 months (p = 0.002) [14].
  • Lung function testing showed reduction of the inspiratory capacity and the single-breath carbon monoxide transfer factor (TLCO) [15].
  • In series II, each of the other 7 subjects performed 12 single breath N2 tests in which the subject inspired both 1 L and an inspiratory capacity (IC) of O2 from FRC with without 10 sec breath-holding [16].
  • We used single inspiratory capacity breaths of 5, 6 or 8% CO2 in air to obtain ventilatory responses in normal subjects, with ensemble averaging of repeated runs to define stimulus and response (Protocol 1) [10].

Gene context of Inspiratory Capacity

  • PATIENTS: Twenty-seven subjects with severe COPD (mean [+/- SD] age, 65 +/- 5 years of age; mean FEV1, 43 +/- 8% predicted; and mean inspiratory capacity [IC]; 74 +/- 14% predicted) [17].
  • Dyspnoea was assessed using the Borg scale, FL by the negative expiratory pressure (NEP) method and hyperinflation in terms of decrease in inspiratory capacity (IC) [18].
  • Adjusted mean pre-exercise inspiratory capacity (IC) on day 42 was 2.41 +/- 0.03 L (tiotropium) vs 2.19 +/- 0.03 L (placebo) at 2.25 h after dosing (p < 0.001), and 2.31 +/- 0.03 L (tiotropium) vs 2.16 +/- 0.03 L (placebo) at 8 h after dosing (p < 0.001) [19].
  • Twenty-two patients with CF were studied (FEV1 17 to 112% of predicted) during progressive bicycle exercise, and changes in EELV were determined by repeat measures of inspiratory capacity [20].
  • After the therapy, inspiratory capacity (IC) and vital capacity (VC) in both the 4 weeks-and 6 weeks-treated groups, and the forced expiratory volume in 1 second (FEV 1.0) in the 6 weeks-treated group were significantly increased, and CO2 retention had also improved [21].

Analytical, diagnostic and therapeutic context of Inspiratory Capacity


  1. Preoperative predictors of prolonged postoperative mechanical ventilation in children following scoliosis repair. Yuan, N., Skaggs, D.L., Dorey, F., Keens, T.G. Pediatr. Pulmonol. (2005) [Pubmed]
  2. Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. O'Donnell, D.E., Revill, S.M., Webb, K.A. Am. J. Respir. Crit. Care Med. (2001) [Pubmed]
  3. Factor analysis of changes in dyspnea and lung function parameters after bronchodilation in chronic obstructive pulmonary disease. Taube, C., Lehnigk, B., Paasch, K., Kirsten, D.K., Jörres, R.A., Magnussen, H. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  4. Spirometric correlates of improvement in exercise performance after anticholinergic therapy in chronic obstructive pulmonary disease. O'Donnell, D.E., Lam, M., Webb, K.A. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  5. Reliability of inspiratory capacity for estimating end-expiratory lung volume changes during exercise in patients with chronic obstructive pulmonary disease. Yan, S., Kaminski, D., Sliwinski, P. Am. J. Respir. Crit. Care Med. (1997) [Pubmed]
  6. Effects of fatigue, fiber length, and aminophylline on human diaphragm contractility. Gauthier, A.P., Yan, S., Sliwinski, P., Macklem, P.T. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  7. Alternative methods for assessing bronchodilator reversibility in chronic obstructive pulmonary disease. Hadcroft, J., Calverley, P.M. Thorax (2001) [Pubmed]
  8. Oxidative enzyme activities of the vastus lateralis muscle and the functional status in patients with COPD. Maltais, F., LeBlanc, P., Whittom, F., Simard, C., Marquis, K., Bélanger, M., Breton, M.J., Jobin, J. Thorax (2000) [Pubmed]
  9. Responses of baboons to prolonged hyperoxia: physiology and qualitative pathology. Fracica, P.J., Knapp, M.J., Piantadosi, C.A., Takeda, K., Fulkerson, W.J., Coleman, R.E., Wolfe, W.G., Crapo, J.D. J. Appl. Physiol. (1991) [Pubmed]
  10. Ventilatory sensitivity to single breaths of CO2 around the control point in man. Fernando, S.S., Saunders, K.B. Respiration physiology. (1995) [Pubmed]
  11. Contribution of quasi-static tissue hysteresis to the dynamic alveolar pressure-volume loop. Robatto, F.M., Romero, P.V., Fredberg, J.J., Ludwig, M.S. J. Appl. Physiol. (1991) [Pubmed]
  12. Dyspnea, respiratory function and sputum profile in asthmatic patients during exacerbations. Rosi, E., Lanini, B., Ronchi, M.C., Romagnoli, I., Stendardi, L., Bianchi, R., Zonefrati, R., Duranti, R., Scano, G. Respiratory medicine. (2002) [Pubmed]
  13. Does inhaled albuterol improve diaphragmatic contractility in patients with chronic obstructive pulmonary disease? Hatipoğlu, U., Laghi, F., Tobin, M.J. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  14. Addition of salmeterol to existing treatment in patients with COPD: a 12 month study. Stockley, R.A., Chopra, N., Rice, L. Thorax (2006) [Pubmed]
  15. Respiratory function changes after asbestos pleurisy. Wright, P.H., Hanson, A., Kreel, L., Capel, L.H. Thorax (1980) [Pubmed]
  16. Inspired volume dependence of the slope of the alveolar plateau. Paiva, M., van Muylem, A., Ravez, P., Yernault, J.C. Respiration physiology. (1984) [Pubmed]
  17. Dyspnea, ventilatory pattern, and changes in dynamic hyperinflation related to the intensity of constant work rate exercise in COPD. Puente-Maestu, L., García de Pedro, J., Martínez-Abad, Y., Ruíz de Oña, J.M., Llorente, D., Cubillo, J.M. Chest (2005) [Pubmed]
  18. Flow limitation and dyspnoea in healthy supine subjects during methacholine challenge. Sulc, J., Volta, C.A., Ploysongsang, Y., Eltayara, L., Olivenstein, R., Milic-Emili, J. Eur. Respir. J. (1999) [Pubmed]
  19. Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD. Maltais, F., Hamilton, A., Marciniuk, D., Hernandez, P., Sciurba, F.C., Richter, K., Kesten, S., O'Donnell, D. Chest (2005) [Pubmed]
  20. Changes in end-expiratory lung volume during exercise in cystic fibrosis relate to severity of lung disease. Regnis, J.A., Alison, J.A., Henke, K.G., Donnelly, P.M., Bye, P.T. Am. Rev. Respir. Dis. (1991) [Pubmed]
  21. Effects of muscle relaxation therapy using specially designed plates in patients with pulmonary emphysema. Fujimoto, K., Kubo, K., Miyahara, T., Matsuzawa, Y., Kobayashi, T., Ono, C., Ito, N. Intern. Med. (1996) [Pubmed]
  22. Breathlessness during acute bronchoconstriction in asthma. Pathophysiologic mechanisms. Lougheed, M.D., Lam, M., Forkert, L., Webb, K.A., O'Donnell, D.E. Am. Rev. Respir. Dis. (1993) [Pubmed]
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