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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Tidal Volume

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Disease relevance of Tidal Volume


Psychiatry related information on Tidal Volume

  • METHOD: Ten patients with panic disorder and six normal control subjects received injections of acetazolamide, 1 g i.v., as per the Mathew et al. protocol, during breath by breath measurement of both tidal volume and frequency of respiration [6].
  • The selective opioid mu receptor agonist dermorphin increased the locomotor activity of rats dose dependently at 10 to 100 pmol/kg i.c.v. Respiratory rate, relative tidal volume and respiratory minute volume also increased unrelated to changes in locomotor activity [7].
  • During wakefulness, the volume threshold (at eupneic fR) averaged 969 +/- 94 ml or 1.3-1.4 times the average eupneic tidal volume; the frequency threshold (at eupneic VT was 14.1 +/- 0.7 min-1 or 1.2 times the average eupneic frequency [8].
  • Medroxyprogesterone acetate elicited chronic increases in inspiratory effect, tidal volume, and alveolar ventilation while awake and during all sleep stages in selected patients with chronic CO2 retention despite severe mechanical impairment and maldistribution ventilation:perfusion [9].
  • However, it is known that during high frequency jet ventilation, PETCO2 may underestimate PaCO2 because of inadequate washout of the anatomical dead space by a small tidal volume and the relatively slow response time of infrared CO2 analyzers [10].

High impact information on Tidal Volume

  • Minute ventilation increased by a mean of 18 percent (P less than 0.0001) in the patients taking theophylline because of increased tidal volume, with no change in respiratory frequency [11].
  • Pulmonary compliance fell and the alveolar-arterial O2 gradient widened in normothermic rats during constant ventilation in the resting tidal volume range, and, in hyperthermic rats (approximately 39 degrees C) similarly ventilated but with the addition of periodic sighs [12].
  • These results indicate that the tidal volume and respiratory timing responses to flow loads are impaired in some patients with COPD [13].
  • Effects of frequency, tidal volume, and lung volume on CO2 elimination in dogs by high frequency (2-30 Hz), low tidal volume ventilation [14].
  • Increased tidal-volume ventilation stimulated secretion; propranolol did not block this effect [15].

Chemical compound and disease context of Tidal Volume


Biological context of Tidal Volume


Anatomical context of Tidal Volume

  • We conclude that in normal humans breathing at rest: (1) aminophylline increases ventilation, promoting larger tidal volume; (2) this effect is due to increased neural drive to inspiratory muscles; (3) aminophylline does not promote any appreciable expiratory muscle recruitment and distortion in the pattern of chest wall motion [26].
  • Treatment with saralasin, 5 mug dissolved in 1 mul saline followed by 9 mul saline in each lateral cerebral ventricle, did not influence tidal volume, but markedly reduced tidal volume variability (p=0.0005), as compared to saline injections (10 mul) [27].
  • In order to investigate the dynamics of both pHecf and neural tidal volume, we measured in cats with cut vagi and sinus nerves the dynamic medullary pHecf changes and the associated changes in integrated phrenic nerve activity after end-tidal CO2 forcing [28].
  • Spinal cord cooling during exercise (0.5 ms-1) at 23 degrees C did not significantly affect O2 consumption, CO2 production, minute volume, tidal volume or respiratory frequency [29].
  • This was accomplished by local application of L-glutamic acid (bilateral application of 5 microliter of a 250-1000 mM solution) and kainic acid (bilateral application of 5 microliter of a 40 mM solution) to the area postrema of chloralose-anesthetized cats while monitoring arterial pressure, heart rate, tidal volume and respiratory rate [30].

Associations of Tidal Volume with chemical compounds

  • An improvement in the estimated ratio of ventilatory dead space to tidal volume (VD/VT), an index of physiologic efficiency, occurred throughout exercise during digoxin therapy, and there was a significant negative correlation between the change in maximal oxygen uptake and change in maximal estimated VD/VT (r = -0.63; p less than 0.05) [31].
  • Animals were studied in a volume-displacement body plethysmograph and changes in pulmonary resistance (RL), dynamic compliance (Cdyn), frequency (f) and tidal volume (VT) were plotted against inhaled histamine concentration (0.016 to 64 mg/ml) [32].
  • With the continuous breathing method, each concentration of methacholine is inhaled by tidal volume breathing for 2 min [33].
  • Although heliox improved gas exchange during HFOV in our model, increased tidal volume delivery may limit clinical applicability [34].
  • Compared with placebo, aminophylline induced an increase in ventilation (p < 0.01) that was mainly accounted for by an increase in tidal volume (p = 0.01) [26].

Gene context of Tidal Volume

  • When exposed to ventilatory stimuli, Hoxa5(-/-) mice maintain the higher minute ventilation by adapting the tidal volume and/or the breathing frequency [35].
  • Reduction of tidal volume during OLV may reduce alveolar concentrations of TNF-alpha and of sICAM-1 [36].
  • After an injection of CRH a stimulation of respiration could be observed, with an increase of tidal volume over a time interval of a few minutes [37].
  • In wild-type mice acute reduction of AChE by Huperzine A (1 mg/kg) to the level found in asymptomatic heterozygotes, induced tremors but no respiratory depression, whereas the same dose of Huperzine in heterozygote animals further reduced AChE activity, increased tidal volume (V(T)) and decreased breathing frequency (f(R)) [38].
  • Therefore, 9 mutant (ob/ob) and 9 wild-type (+/+) mice were exposed to room air or 100% oxygen and respiratory rate (RR) and tidal volume (Vt) were measured [39].

Analytical, diagnostic and therapeutic context of Tidal Volume

  • On the basis of test lung data and plethysmography measurements, we also conclude that heliox improves carbon dioxide elimination primarily through increased tidal volume delivery [34].
  • METHODS: Oxygen saturation (SaO(2)), transcutaneous carbon dioxide (TcCO(2)), minute ventilation (VE), tidal volume (VT), respiratory rate (RR), and diaphragm electromyography (EMGdi) were measured in 15 patients during both modes [40].
  • METHODS--Eight subjects were selected from 34 consecutive asthmatic patients who had previously exhibited a significant increase in respiratory frequency (Rf) and decrease in tidal volume (VT) accompanying a 20% or greater fall in FEV1 during a histamine bronchial provocation test [41].
  • Pain was induced by a modification of the Tourniquet Pain Technique and changes in ventilatory parameters were registered through monitoring of the CO2 response of tidal volume, minute ventilation, respiratory rate and mouth occlusion pressure [42].
  • BACKGROUND: We previously demonstrated a markedly dependent distribution of ventilator-induced lung injury in oleic acid-injured supine animals ventilated with large tidal volumes and positive end-expiratory pressure > or =10 cm H2O [43].


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  14. Effects of frequency, tidal volume, and lung volume on CO2 elimination in dogs by high frequency (2-30 Hz), low tidal volume ventilation. Slutsky, A.S., Kamm, R.D., Rossing, T.H., Loring, S.H., Lehr, J., Shapiro, A.H., Ingram, R.H., Drazen, J.M. J. Clin. Invest. (1981) [Pubmed]
  15. Regulation of secretion in Clara cells: studies using the isolated perfused rat lung. Massaro, G.D., Fischman, C.M., Chiang, M.J., Amado, C., Massaro, D. J. Clin. Invest. (1981) [Pubmed]
  16. The effect of prenatal exposure to carbon monoxide on breathing and growth of the newborn guinea pig. McGregor, H.P., Westcott, K., Walker, D.W. Pediatr. Res. (1998) [Pubmed]
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  27. Intracerebroventricular administration of the angiotensin II receptor antagonist saralasin reduces respiratory rate and tidal volume variability in freely moving Wistar rats. Olsson, M., Annerbrink, K., Hedner, J., Eriksson, E. Psychoneuroendocrinology (2004) [Pubmed]
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