High impact information on Isotonic Contraction

• Titin-driven passive recoil was much faster than active unloaded shortening velocity in early phases of isotonic contraction [1].
• Isoproterenol shortened both the preshortening period and the isotonic contraction time, while an increase in calcium shortened the preshortening period and lengthened the isotonic contraction time [2].
• Two ligands, adenosine 5' (beta, gamma-imido) triphosphate (AMPPNP) and pyrophosphate (PPi), decreased the force and stiffness developed in isometric contractions and the velocity of shortening of isotonic contractions [3].
• Adhesion modulates contractility (isometric or isotonic contraction) and vice versa and this determines morphology (shape, F-actin, myosin and alpha-actinin), locomotion and responses to microtubule-disassembly [4].
• 3. The affinity estimates for L-365,260, although obtained on different tissues, are consistent with data obtained from the analysis of L-365,260 antagonism of pentagastrin-stimulated responses in mouse and rat stomach (acid secretion) and guinea-pig gastric muscle (isotonic contraction) assays [5].

Biological context of Isotonic Contraction

• In afterloaded isotonic contractions, daunomycin increased the mean work output (W; averaged over all load levels) by 49%, but there was an even greater increment in the associated energy expenditure, ET, which rose by 66% [6].

Anatomical context of Isotonic Contraction

• The temperature dependency of binding of acetylthiocholine, a specific nicotinic agonist, to the nicotinic receptor of mammalian skeletal muscle was studied using isotonic contractions of the rat denervated diaphragm preparation in vitro [7].
• The present study demonstrates that rhTNFalpha increases maximal isotonic contraction of tracheal smooth muscle to methacholine (mean+/-SEM 169.6+/-43%, p<0.005) [8].
• In a longitudinal muscle preparation from guinea pig ileum, 10(-6) M BASS almost irreversibly inhibited an isotonic contraction induced by acetylcholine (ACH) and made the dose-response curve shift in parallel to the right (pA2: 7.6) [9].

Associations of Isotonic Contraction with chemical compounds

• Maximum isotonic contractions elicited by potassium chloride (KCl) in both regions of the bladder were unaffected by age [10].
• The acetylcholine (ACh)-induced isotonic contraction of circularly cut muscle strips was recorded and expressed as a percentage of the maximum contraction obtained with 80 mM K+ [11].
• Isotonic contractions of the irides upon field stimulation consisted of a rapid, atropine (0.1 mumol/l)-sensitive peak phase followed by a sustained contraction which involved a cholinergic and a non-cholinergic stimulation of the sphincter muscle [12].
• Changes in discharge rate of fusimotor neurones to pretibial flexor muscles were recorded during and after long-lasting fatiguing isometric and/or isotonic contractions of triceps surae in decerebrate cats [13].
• Initial power output (W) during repetitive tetanic (200 ms, 50 impulses/s) isotonic contractions was similar in both groups; however, W declined significantly more (30-80%) in PFKD than in NORM muscle over time, with a constant O2 uptake (VO2)/W [14].

References