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MeSH Review

Marijuana Smoking

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Disease relevance of Marijuana Smoking


Psychiatry related information on Marijuana Smoking


High impact information on Marijuana Smoking


Chemical compound and disease context of Marijuana Smoking

  • In view of associated findings that marijuana smoking decreased myocardial oxygen delivery, decreased exercise time until the onset of anginal pain, and increased myocardial oxygen demand in anginal patients, the use of marijuana by such patients is clearly inadvisable [11].
  • This study was conducted to determine if plasma ethanol levels are altered as a result of smoking marihuana [12].
  • During placebo marijuana smoking, i.e., active marijuana withdrawal, ratings of irritability, restlessness, depression, and trouble sleeping were increased by bupropion compared to placebo maintenance [13].
  • Clonidine partially blocks the physiologic effects but not the subjective effects produced by smoking marijuana in male human subjects [14].
  • Brodifacoum intoxication with marijuana smoking [15].

Anatomical context of Marijuana Smoking


Gene context of Marijuana Smoking

  • These studies suggest that marijuana smoking and immune activation can alter the basal levels of CB1 and CB2 in PBMCs [17].
  • Concentrations of THC and CBD, comparable to plasma levels found after smoking marijuana (10-100 ng/ml), increased the concentration of measurable IFN (139 and 68%), while high concentrations of both cannabinoids (5-20 micrograms/ml) completely blocked synthesis and/or release of this cytokine [18].
  • Marijuana smoking was associated with bilateral CBF increase, which was maximal 30 min later [19].
  • In the present study, the potential mutagenic effects of marijuana smoking were investigated with a somatic cell mutation assay that detects mutations occurring in vivo in the hprt gene [20].
  • Significant changes were observed in the serum total lipids, triglycerides and HDL subfractions after hashish smoking [21].

Analytical, diagnostic and therapeutic context of Marijuana Smoking

  • To investigate the effects of chronic marijuana smoking on lung function, pulmonary function tests including single-breath carbon monoxide diffusing capacities were performed in 15 healthy women who smoked 1.7 +/- 1.4 (mean +/- SD) marijuana cigarettes per day for 235 +/- 135 days per year for a mean of 10.5 +/- 3.7 years [22].


  1. Histopathologic and molecular alterations in bronchial epithelium in habitual smokers of marijuana, cocaine, and/or tobacco. Barsky, S.H., Roth, M.D., Kleerup, E.C., Simmons, M., Tashkin, D.P. J. Natl. Cancer Inst. (1998) [Pubmed]
  2. Persistent pulmonary hypertension of the newborn and smoking and aspirin and nonsteroidal antiinflammatory drug consumption during pregnancy. Van Marter, L.J., Leviton, A., Allred, E.N., Pagano, M., Sullivan, K.F., Cohen, A., Epstein, M.F. Pediatrics (1996) [Pubmed]
  3. Case study: adverse effects of smoking marijuana while receiving tricyclic antidepressants. Wilens, T.E., Biederman, J., Spencer, T.J. Journal of the American Academy of Child and Adolescent Psychiatry. (1997) [Pubmed]
  4. The cannabinoid CB1 receptor antagonist rimonabant attenuates the hypotensive effect of smoked marijuana in male smokers. Gorelick, D.A., Heishman, S.J., Preston, K.L., Nelson, R.A., Moolchan, E.T., Huestis, M.A. Am. Heart J. (2006) [Pubmed]
  5. Sex, drugs, and HIV: does methadone maintenance reduce drug use and risky sexual behavior? Lollis, C.M., Strothers, H.S., Chitwood, D.D., McGhee, M. Journal of behavioral medicine. (2000) [Pubmed]
  6. Pulmonary hazards of smoking marijuana as compared with tobacco. Wu, T.C., Tashkin, D.P., Djahed, B., Rose, J.E. N. Engl. J. Med. (1988) [Pubmed]
  7. Hepatitis B in Nuremberg, Germany. Epidemiology of a drug-associated epidemic. Among US Army soldiers. Cates, W., Warren, J.W. JAMA (1975) [Pubmed]
  8. Effects of smoking marihuana on left ventricular performance and plasma norepinephrine: studies in normal men. Gash, A., Karliner, J.S., Janowsky, D., Lake, C.R. Ann. Intern. Med. (1978) [Pubmed]
  9. Heavy habitual marijuana smoking does not cause an accelerated decline in FEV1 with age. Tashkin, D.P., Simmons, M.S., Sherrill, D.L., Coulson, A.H. Am. J. Respir. Crit. Care Med. (1997) [Pubmed]
  10. Short-term effects of smoking marijuana on balance in patients with multiple sclerosis and normal volunteers. Greenberg, H.S., Werness, S.A., Pugh, J.E., Andrus, R.O., Anderson, D.J., Domino, E.F. Clin. Pharmacol. Ther. (1994) [Pubmed]
  11. Effect of marijuana and placebo-marijuana smoking on psychological state and on psychophysiological cardiovascular functioning in anginal patients. Gottschalk, L.A., Aronow, W.S., Prakash, R. Biol. Psychiatry (1977) [Pubmed]
  12. Marihuana attenuates the rise in plasma ethanol levels in human subjects. Lukas, S.E., Benedikt, R., Mendelson, J.H., Kouri, E., Sholar, M., Amass, L. Neuropsychopharmacology (1992) [Pubmed]
  13. Bupropion SR worsens mood during marijuana withdrawal in humans. Haney, M., Ward, A.S., Comer, S.D., Hart, C.L., Foltin, R.W., Fischman, M.W. Psychopharmacology (Berl.) (2001) [Pubmed]
  14. Clonidine partially blocks the physiologic effects but not the subjective effects produced by smoking marijuana in male human subjects. Cone, E.J., Welch, P., Lange, W.R. Pharmacol. Biochem. Behav. (1988) [Pubmed]
  15. Brodifacoum intoxication with marijuana smoking. La Rosa, F.G., Clarke, S.H., Lefkowitz, J.B. Arch. Pathol. Lab. Med. (1997) [Pubmed]
  16. A prospective study of the effects of female and male marijuana use on in vitro fertilization (IVF) and gamete intrafallopian transfer (GIFT) outcomes. Klonoff-Cohen, H.S., Natarajan, L., Chen, R.V. Am. J. Obstet. Gynecol. (2006) [Pubmed]
  17. Altered cannabinoid receptor mRNA expression in peripheral blood mononuclear cells from marijuana smokers. Nong, L., Newton, C., Cheng, Q., Friedman, H., Roth, M.D., Klein, T.W. J. Neuroimmunol. (2002) [Pubmed]
  18. Marijuana components stimulate human peripheral blood mononuclear cell secretion of interferon-gamma and suppress interleukin-1 alpha in vitro. Watzl, B., Scuderi, P., Watson, R.R. Int. J. Immunopharmacol. (1991) [Pubmed]
  19. Regional cerebral blood flow after marijuana smoking. Mathew, R.J., Wilson, W.H., Humphreys, D.F., Lowe, J.V., Wiethe, K.E. J. Cereb. Blood Flow Metab. (1992) [Pubmed]
  20. Frequencies of hprt mutant lymphocytes in marijuana-smoking mothers and their newborns. Ammenheuser, M.M., Berenson, A.B., Babiak, A.E., Singleton, C.R., Whorton, E.B. Mutat. Res. (1998) [Pubmed]
  21. Changes of HDL-lipid composition as related to delta 9-THC action. Kalofoutis, A., Dionyssiou-Asteriou, A., Maravelias, C., Koutselinis, A. Pharmacol. Biochem. Behav. (1985) [Pubmed]
  22. Marijuana smoking as cause of reduction in single-breath carbon monoxide diffusing capacity. Tilles, D.S., Goldenheim, P.D., Johnson, D.C., Mendelson, J.H., Mello, N.K., Hales, C.A. Am. J. Med. (1986) [Pubmed]
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