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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Disease Transmission

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Disease relevance of Disease Transmission

  • This novel feature of CCR5 may modulate its signaling potential and could explain its preferential use by HIV for person-to-person transmission of disease [1].
  • The subset of families with no evidence of male-to-male disease transmission and with early-onset prostate cancer (average age at diagnosis within a family < or = 65 years) contributed disproportionately to the evidence for linkage for the entire dataset in the HPCX candidate region (near marker DXS1113) [2].
  • Major clinical problems in the treatment of hemophilia A include the transmission of disease by therapeutic blood products and the development of alloantibody inhibitors to transfused Factor VIII [3].
  • If there is a wide distribution of risk of HSV-2 transmission over the course of an infection then practicable aciclovir use is unlikely to have any great impact on disease transmission dynamics [4].
  • Results from this 3-yr trial indicate that the use of fipronil passively applied to reservoir animals by bait boxes is an environmentally acceptable means to control ticks, interrupt the natural disease transmission cycle, and reduce the risk of Lyme disease for residents of treated properties [5].

High impact information on Disease Transmission


Chemical compound and disease context of Disease Transmission


Biological context of Disease Transmission


Associations of Disease Transmission with chemical compounds

  • Major questions relate to the relevance of the glycoform distribution (as defined by glycan site occupancy) to strain type and disease transmission [17].
  • In addition, many aspects of parkin-linked disease, originally thought to be well defined, have now been obscured both by genetic studies that preclude a simple model of disease transmission and by clinical and pathological studies that demonstrate broad variability in cases with parkin mutations [18].
  • OBJECTIVE: The use of hydroxyapatite-based ceramics for cranioplasties has recently increased in Japan, because of the good cosmetic outcomes, biocompatibility, strength, osteoconductive properties, and lack of risk of disease transmission associated with these materials [19].
  • Latex products commonly are used as essential barriers against the transmission of disease, and so guayule hypoallergenic latex medical products would be a viable alternative only if they possess effective viral barrier properties [20].
  • Commercial hatcheries typically infuse hydrogen peroxide or formaldehyde gas into hatching cabinets to reduce airborne pathogens that may lead to disease transmission during the hatch [21].

Gene context of Disease Transmission

  • In order to assess attitudes and practices of physicians regarding prescribing syringes to injection drug users (IDUs) to prevent disease transmission, a survey was conducted at the 2000 ASAM Conference. Of 497 physicians, 104 responded, representing 30 states and 3 countries [22].
  • With the rise in global travel, preventing disease transmission has become paramount to avoid the spread of infectious diseases, including SARS (severe acute respiratory syndrome), avian influenza, and haemorrhagic fever [23].
  • Motivated by the 2001 FMD epidemic in the UK, we determine, using stochastic simulations and deterministic 'moment closure' models of disease transmission on networks of premises (nodes), network and disease properties that are important for contact tracing efficiency [24].
  • This study, the first in Italy since the discovery of the DM gene, underlines the importance of direct genetic diagnosis of DM, especially in detecting mildly affected patients, a fundamental step in correctly estimating the risk of disease transmission in affected families [25].
  • The Multifactorial Model of Disease Transmission was used to estimate familial correlations and these were parameterized by the "Tau" model of Familial Transmission [26].

Analytical, diagnostic and therapeutic context of Disease Transmission


  1. Distinct mechanisms of agonist-induced endocytosis for human chemokine receptors CCR5 and CXCR4. Venkatesan, S., Rose, J.J., Lodge, R., Murphy, P.M., Foley, J.F. Mol. Biol. Cell (2003) [Pubmed]
  2. Linkage analysis of 153 prostate cancer families over a 30-cM region containing the putative susceptibility locus HPCX. Lange, E.M., Chen, H., Brierley, K., Perrone, E.E., Bock, C.H., Gillanders, E., Ray, M.E., Cooney, K.A. Clin. Cancer Res. (1999) [Pubmed]
  3. Recombinant DNA methods in hemophilia A: carrier detection and prenatal diagnosis. Sadler, J.E. Semin. Thromb. Hemost. (1990) [Pubmed]
  4. Use of antiviral treatment and prophylaxis is unlikely to have a major impact on the prevalence of herpes simplex virus type 2. White, P.J., Garnett, G.P. Sexually transmitted infections. (1999) [Pubmed]
  5. Control of immature Ixodes scapularis (Acari: Ixodidae) on rodent reservoirs of Borrelia burgdorferi in a residential community of southeastern Connecticut. Dolan, M.C., Maupin, G.O., Schneider, B.S., Denatale, C., Hamon, N., Cole, C., Zeidner, N.S., Stafford, K.C. J. Med. Entomol. (2004) [Pubmed]
  6. Novel inheritance of the murine severe combined anemia and thrombocytopenia (Scat) phenotype. Peters, L.L., Barker, J.E. Cell (1993) [Pubmed]
  7. Beyond Mendel: an evolving view of human genetic disease transmission. Badano, J.L., Katsanis, N. Nat. Rev. Genet. (2002) [Pubmed]
  8. Genetic interaction of BBS1 mutations with alleles at other BBS loci can result in non-Mendelian Bardet-Biedl syndrome. Beales, P.L., Badano, J.L., Ross, A.J., Ansley, S.J., Hoskins, B.E., Kirsten, B., Mein, C.A., Froguel, P., Scambler, P.J., Lewis, R.A., Lupski, J.R., Katsanis, N. Am. J. Hum. Genet. (2003) [Pubmed]
  9. Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein. Hsiao, K.K., Groth, D., Scott, M., Yang, S.L., Serban, H., Rapp, D., Foster, D., Torchia, M., Dearmond, S.J., Prusiner, S.B. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  10. PHOX2B mutations and genetic predisposition to neuroblastoma. Perri, P., Bachetti, T., Longo, L., Matera, I., Seri, M., Tonini, G.P., Ceccherini, I. Oncogene (2005) [Pubmed]
  11. Antiretroviral treatment of men infected with human immunodeficiency virus type 1 reduces the incidence of heterosexual transmission. Italian Study Group on HIV Heterosexual Transmission. Musicco, M., Lazzarin, A., Nicolosi, A., Gasparini, M., Costigliola, P., Arici, C., Saracco, A. Arch. Intern. Med. (1994) [Pubmed]
  12. The oligogenic properties of Bardet-Biedl syndrome. Katsanis, N. Hum. Mol. Genet. (2004) [Pubmed]
  13. Transmission control and drug resistance in malaria: a crucial interaction. Molyneux, D.H., Floyd, K., Barnish, G., Fèvre, E.M. Parasitol. Today (Regul. Ed.) (1999) [Pubmed]
  14. The role of IL-4 in adult acquired and congenital toxoplasmosis. Alexander, J., Jebbari, H., Bluethmann, H., Brombacher, F., Roberts, C.W. Int. J. Parasitol. (1998) [Pubmed]
  15. Monoclonal antibodies for reproductive health: Part I. Preventing sexual transmission of disease and pregnancy with topically applied antibodies. Cone, R.A., Whaley, K.J. Am. J. Reprod. Immunol. (1994) [Pubmed]
  16. The significance of using pooled human serum in human articular cartilage tissue engineering. Azmi, B., Aminuddin, B.S., Sharaf, I., Samsudin, O.C., Munirah, S., Chua, K.H., Ruszymah, B.H. Med. J. Malaysia (2004) [Pubmed]
  17. Prion glycoprotein: structure, dynamics, and roles for the sugars. Rudd, P.M., Wormald, M.R., Wing, D.R., Prusiner, S.B., Dwek, R.A. Biochemistry (2001) [Pubmed]
  18. Genetics of parkin-linked disease. West, A.B., Maidment, N.T. Hum. Genet. (2004) [Pubmed]
  19. A new technique for cranioplasty with L-shaped titanium plates and combination ceramic implants composed of hydroxyapatite and tricalcium phosphate (Ceratite). Miyake, H., Ohta, T., Tanaka, H. Neurosurgery (2000) [Pubmed]
  20. Viral impermeability of hypoallergenic, low protein, guayule latex films. Cornish, K., Lytle, C.D. J. Biomed. Mater. Res. (1999) [Pubmed]
  21. Reducing airborne pathogens and dust in commercial hatching cabinets with an electrostatic space charge system. Mitchell, B.W., Waltman, W.D. Avian Dis. (2003) [Pubmed]
  22. Would you consider prescribing syringes to injection drug users? Addiction Medicine Conference Survey. Taylor, L.E., Runarsdottir, V., Zampi, A., Osei, A., Sanford, S., Macalino, G., McKenzie, M., Burris, S., Gross, J.D., Reinert, S.E., Rich, J.D. Journal of addictive diseases : the official journal of the ASAM, American Society of Addiction Medicine. (2003) [Pubmed]
  23. Health risks at the Hajj. Ahmed, Q.A., Arabi, Y.M., Memish, Z.A. Lancet (2006) [Pubmed]
  24. Disease contact tracing in random and clustered networks. Kiss, I.Z., Green, D.M., Kao, R.R. Proc. Biol. Sci. (2005) [Pubmed]
  25. Epidemiology of myotonic dystrophy in Italy: re-apprisal after genetic diagnosis. Siciliano, G., Manca, M., Gennarelli, M., Angelini, C., Rocchi, A., Iudice, A., Miorin, M., Mostacciuolo, M. Clin. Genet. (2001) [Pubmed]
  26. Secular trends in the familial transmission of alcoholism. Reich, T., Cloninger, C.R., Van Eerdewegh, P., Rice, J.P., Mullaney, J. Alcohol. Clin. Exp. Res. (1988) [Pubmed]
  27. Compatibility of the argon and KTP lasers with middle ear implants. Wanamaker, H.H., Silverstein, H. Laryngoscope (1993) [Pubmed]
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