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MeSH Review

Adenoma, Sweat Gland

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Disease relevance of Adenoma, Sweat Gland


High impact information on Adenoma, Sweat Gland


Chemical compound and disease context of Adenoma, Sweat Gland

  • Papillary hidradenoma: immunohistochemical analysis of steroid receptor profile with a focus on apocrine differentiation [9].
  • Therefore, we think that the luminal cells in solid cystic hidradenoma mainly differentiate toward the secretory cells, and that the M nests mainly differentiate toward the dermal duct [10].
  • CONCLUSIONS: Oestrogen and progesterone receptors seem to represent reliable markers for differentiating between anogenital sweat glands and conventional sweat glands, and a further link to explain why papillary hidradenomas occur almost exclusively in the female anogenital region [9].
  • Light microscopy of hematoxylin and eosin-stained sections showed a large, fairly well-defined cystic nodular hidradenoma with areas infiltrated by numerous closely arranged, large, uniform, oval and polygonal cells with abundant intensely eosinophilic cytoplasm and small central, dark, round nuclei [11].
  • A case of papillary syringadenoma that was located on the right side of the vermilion border of the lower lip in a 24-year-old man is described [12].

Gene context of Adenoma, Sweat Gland

  • Phenotypic heterogeneity of nodular hidradenoma. Immunohistochemical analysis with emphasis on cytokeratin expression [13].
  • Apocrine tumors such as apocrine hidrocystoma, syringocystadenoma papilliferum, or hidradenoma papilliferum showed intense CD44 positivity in the portion of cells in contact with the neighboring stroma and focally on the luminal side of cells with apocrine secretion [14].
  • No staining for GCDFP-24 occurred among the following SGT: eccrine hidrocystoma (two cases), eccrine poroma (three cases), syringoma (eight cases), eccrine spiradenoma (two cases), or clear cell hidradenoma (five cases) [5].
  • S-100 protein in nodular hidradenoma [15].
  • There was no immunoreactivity for GCDFP-15 for tumors of probable eccrine differentiation, including five cases of eccrine hidrocystoma, five cases of eccrine poroma, five cases of eccrine spiradenoma, 10 cases of clear cell hidradenoma, and nine cases of syringoma [16].


  1. Her-2 expression in cutaneous eccrine and apocrine neoplasms. Hiatt, K.M., Pillow, J.L., Smoller, B.R. Mod. Pathol. (2004) [Pubmed]
  2. Immunoreactivity for estrogen receptor protein in sweat gland tumors. Swanson, P.E., Mazoujian, G., Mills, S.E., Campbell, R.J., Wick, M.R. Am. J. Surg. Pathol. (1991) [Pubmed]
  3. Expression of differentiation antigens in benign sweat gland tumours. Kariniemi, A.L., Forsman, L.M., Wahlström, T., Andersson, L.C. Br. J. Dermatol. (1984) [Pubmed]
  4. A histochemical and immunohistochemical study of extra-ocular sebaceous carcinoma. Ansai, S., Hashimoto, H., Aoki, T., Hozumi, Y., Aso, K. Histopathology (1993) [Pubmed]
  5. Immunohistochemistry of GCDFP-24 and zinc alpha2 glycoprotein in benign sweat gland tumors. Mazoujian, G. The American Journal of dermatopathology. (1990) [Pubmed]
  6. Nodular hidradenoma and hidradenocarcinoma. A 10-year review. Hernández-Pérez, E., Cestoni-Parducci, R. J. Am. Acad. Dermatol. (1985) [Pubmed]
  7. Clear Cell Hidradenoma of the Skin-A Third Tumor Type With a t(11;19)-Associated TORC1-MAML2 Gene Fusion: Genes Chromosomes Cancer. 2005;43:202-205. El-Naggar, A.K. Advances in anatomic pathology. (2006) [Pubmed]
  8. Recurrent clear cell hidradenoma of the foot. Will, R., Coldiron, B. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2000) [Pubmed]
  9. Papillary hidradenoma: immunohistochemical analysis of steroid receptor profile with a focus on apocrine differentiation. Offidani, A., Campanati, A. J. Clin. Pathol. (1999) [Pubmed]
  10. Histogenesis of clear cell hidradenoma: immunohistochemical study of keratin expression. Ohnishi, T., Watanabe, S. J. Cutan. Pathol. (1997) [Pubmed]
  11. Oncocytic nodular hidradenoma. Roth, M.J., Stern, J.B., Hijazi, Y., Haupt, H.M., Kumar, A. The American Journal of dermatopathology. (1996) [Pubmed]
  12. Papillary syringadenoma of the lower lip: report of a case. Triantafyllou, A.G., Laskaris, G.C. J. Oral Maxillofac. Surg. (1987) [Pubmed]
  13. Phenotypic heterogeneity of nodular hidradenoma. Immunohistochemical analysis with emphasis on cytokeratin expression. Biernat, W., Kordek, R., Woźniak, L. The American Journal of dermatopathology. (1996) [Pubmed]
  14. CD44 distribution in sweat gland tumors suggests it has different functional roles in the various cell types. Fernández-Figueras, M.T., Puig, L., Ariza, A., Calatrava, A., Fuente, M.J., Ferrándiz, C. The American Journal of dermatopathology. (1996) [Pubmed]
  15. S-100 protein in nodular hidradenoma. Yashar, S.S. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (1999) [Pubmed]
  16. Immunohistochemistry of gross cystic disease fluid protein (GCDFP-15) in 65 benign sweat gland tumors of the skin. Mazoujian, G., Margolis, R. The American Journal of dermatopathology. (1988) [Pubmed]
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